DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 2036:2042

E3 ligase: FBXW7

DEGRON score: 0.998

ASA_SCORE: 86.1429

COIL: 0.9433

CONS_SCORE: 0.2064

DSS_SCORE: 0.6153

HELIX: 0.0113

FCONS_SCORE: 0.9881

RIG_SCORE: 0.6354

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2039R	TCGA-34-5239	LUSC	TCGA	VATPSST	DEG_SCF_FBW7_1	0.7512
p.P2039S	TCGA-A1-A0SN	BRCA	TCGA	VATPSST	DEG_SCF_FBW7_1	0.6752
p.P2039S	TCGA-F4-6703	COAD	TCGA	VATPSST	DEG_SCF_FBW7_1	0.6752
p.A2037V	TCGA-AA-3492	COAD	TCGA	VATPSST	DEG_SCF_FBW7_1	0.5825
p.G2031V	TCGA-CD-A4MG	STAD	TCGA	VATPSST	DEG_SCF_FBW7_1	0.1944
p.T2028S	TCGA-CJ-4902	KIRC	TCGA	VATPSST	DEG_SCF_FBW7_1	0.1111
p.T2042N	TCGA-DK-A6B5	BLCA	TCGA	VATPSST	DEG_SCF_FBW7_1	0.7055
p.G2031E	TCGA-EE-A29M	SKCM	TCGA	VATPSST	DEG_SCF_FBW7_1	0.1944
p.A2046V	TCGA-HU-A4HD	STAD	TCGA	VATPSST	DEG_SCF_FBW7_1	0.2222
p.T2045N	DO48551	BLCA	ICGC	VATPSST	DEG_SCF_FBW7_1	0.25
p.P2042S	DO4299	BRCA	ICGC	VATPSST	DEG_SCF_FBW7_1	0.6752
p.P2042S	DO9908	COAD	ICGC	VATPSST	DEG_SCF_FBW7_1	0.6752
p.A2040V	DO8224	COAD	ICGC	VATPSST	DEG_SCF_FBW7_1	0.6936
p.T2031S	DO17693	KIRC	ICGC	VATPSST	DEG_SCF_FBW7_1	0.1944
p.A2030S	DO229019	LICA	ICGC	VATPSST	DEG_SCF_FBW7_1	0.1667
p.T2041I	DO229047	LICA	ICGC	VATPSST	DEG_SCF_FBW7_1	0.7078
p.T2027N	DO26822	LUSC	ICGC	VATPSST	DEG_SCF_FBW7_1	0.0833
p.P2042R	DO27660	LUSC	ICGC	VATPSST	DEG_SCF_FBW7_1	0.7512
p.G2034E	DO37404	SKCM	ICGC	VATPSST	DEG_SCF_FBW7_1	0.2778
p.G2034V	DO48009	STAD	ICGC	VATPSST	DEG_SCF_FBW7_1	0.2778
p.A2049V	DO47989	STAD	ICGC	VATPSST	DEG_SCF_FBW7_1	0.5833
p.P2039H	SIDM01307	Colorectal Carcinoma	GDSC	VATPSST	DEG_SCF_FBW7_1	0.7694
p.G2044E	SIDM00545	Melanoma	GDSC	VATPSST	DEG_SCF_FBW7_1	0.2778
p.G2044E	ACH-000987	Skin Cancer	CCLE	VATPSST	DEG_SCF_FBW7_1	0.2778
p.G2044E	Mewo	skin	COSMIC	VATPSST	DEG_SCF_FBW7_1	0.2778
p.T2038I	SIDM00495	B-Cell Non-Hodgkin's Lymphoma	GDSC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	SIDM00584	Osteosarcoma	GDSC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	SIDM00602	Gastric Carcinoma	GDSC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	SIDM00492	Glioblastoma	GDSC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	SIDM00564	Ovarian Carcinoma	GDSC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	SIDM00488	Colorectal Carcinoma	GDSC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	SIDM00502	B-Lymphoblastic Leukemia	GDSC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	SIDM00397	Acute Myeloid Leukemia	GDSC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	SIDM00289	B-Lymphoblastic Leukemia	GDSC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	SIDM00996	Thyroid Gland Carcinoma	GDSC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	SIDM00591	Oral Cavity Carcinoma	GDSC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	SIDM00273	Glioblastoma	GDSC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	SIDM00575	Glioma	GDSC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	SIDM00531	Pancreatic Carcinoma	GDSC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	SIDM01727	Chronic Myelogenous Leukemia	GDSC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	SIDM00168	Head and Neck Carcinoma	GDSC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	SIDM01685	B-Lymphoblastic Leukemia	GDSC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	SIDM01662	Plasma Cell Myeloma	GDSC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	SIDM01694	B-Lymphoblastic Leukemia	GDSC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	NMC-G1	central_nervous_system	COSMIC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	AM-38	central_nervous_system	COSMIC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	8505C	thyroid	COSMIC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	A3-KAW	haematopoietic_and_lymphoid_tissue	COSMIC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	HAL-01	haematopoietic_and_lymphoid_tissue	COSMIC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	OVISE	ovary	COSMIC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	GI-1	central_nervous_system	COSMIC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	HuP-T4	pancreas	COSMIC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	Set2	haematopoietic_and_lymphoid_tissue	COSMIC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	IM-95	stomach	COSMIC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	CaR-1	large_intestine	COSMIC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	HO-1-u-1	upper_aerodigestive_tract	COSMIC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T2038I	HuO-3N1	bone	COSMIC	VATPSST	DEG_SCF_FBW7_1	0.8189
p.P2043T	SIDM00951	T-Lymphoblastic Leukemia	GDSC	VATPSST	DEG_SCF_FBW7_1	0.3056
p.P2043T	ACH-002222	Leukemia	CCLE	VATPSST	DEG_SCF_FBW7_1	0.3056
p.P2043T	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	VATPSST	DEG_SCF_FBW7_1	0.3056
p.T2045R	SIDM01763	Rhabdomyosarcoma	GDSC	VATPSST	DEG_SCF_FBW7_1	0.25
p.T2042I	EM-2	haematopoietic_and_lymphoid_tissue	COSMIC	VATPSST	DEG_SCF_FBW7_1	0.7078
p.T2042I	U-87-MG	central_nervous_system	COSMIC	VATPSST	DEG_SCF_FBW7_1	0.7078
p.T2042I	HCC202	breast	COSMIC	VATPSST	DEG_SCF_FBW7_1	0.7078

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VATPSST

Degron related mutations and impact score

Drug responses associated with MUC5B mutations

All proteins holding degron of VATPSST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI2	Connector enhancer of kinase suppressor of ras 2	DEG_SCF_FBW7_1	330:336	VATPSST	FBXW7	0.9917	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2036:2042	VATPSST	FBXW7	0.998	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2593:2599	VATPSST	FBXW7	0.9911	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3293:3299	VATPSST	FBXW7	0.9557	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3850:3856	VATPSST	FBXW7	0.993	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4578:4584	VATPSST	FBXW7	0.9844	More...