DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 4578:4584

E3 ligase: FBXW7

DEGRON score: 0.9844

ASA_SCORE: 90.4143

COIL: 0.9341

CONS_SCORE: 0.2839

DSS_SCORE: 0.6118

HELIX: 0.0114

FCONS_SCORE: -0.0021

RIG_SCORE: 0.6417

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G4576S	TCGA-B5-A3FA	UCEC	TCGA	VATPSST	DEG_SCF_FBW7_1	0.2778
p.T4580I	TCGA-CF-A3MH	BLCA	TCGA	VATPSST	DEG_SCF_FBW7_1	0.8189
p.T4583I	DO791	BLCA	ICGC	VATPSST	DEG_SCF_FBW7_1	0.7078
p.A4570D	DO15126	HNSC	ICGC	VATPSST	DEG_SCF_FBW7_1	0.1111
p.G4579S	DO52402	UCEC	ICGC	VATPSST	DEG_SCF_FBW7_1	0.6993
p.T4570S	SIDM00741	Small Cell Lung Carcinoma	GDSC	VATPSST	DEG_SCF_FBW7_1	0.1111
p.T4570S	ACH-000431	Lung Cancer	CCLE	VATPSST	DEG_SCF_FBW7_1	0.1111
p.T4570S	NCI-H1694	lung	COSMIC	VATPSST	DEG_SCF_FBW7_1	0.1111
p.S4583T	SIDM00965	Small Cell Lung Carcinoma	GDSC	VATPSST	DEG_SCF_FBW7_1	0.7116
p.S4583T	ACH-000800	Lung Cancer	CCLE	VATPSST	DEG_SCF_FBW7_1	0.7116
p.S4583T	NCI-H446	lung	COSMIC	VATPSST	DEG_SCF_FBW7_1	0.7116
p.A4574V	SIDM00217	Colorectal Carcinoma	GDSC	VATPSST	DEG_SCF_FBW7_1	0.2222
p.A4574V	ACH-000999	Colon/Colorectal Cancer	CCLE	VATPSST	DEG_SCF_FBW7_1	0.2222
p.A4574V	SNU-1040	large_intestine	COSMIC	VATPSST	DEG_SCF_FBW7_1	0.2222
p.T4584I	BICR78	upper_aerodigestive_tract	COSMIC	VATPSST	DEG_SCF_FBW7_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI2	Connector enhancer of kinase suppressor of ras 2	DEG_SCF_FBW7_1	330:336	VATPSST	FBXW7	0.9917	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2036:2042	VATPSST	FBXW7	0.998	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2593:2599	VATPSST	FBXW7	0.9911	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3293:3299	VATPSST	FBXW7	0.9557	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3850:3856	VATPSST	FBXW7	0.993	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4578:4584	VATPSST	FBXW7	0.9844	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons