DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 3850:3856

E3 ligase: FBXW7

DEGRON score: 0.993

ASA_SCORE: 90.2

COIL: 0.9323

CONS_SCORE: 0.2938

DSS_SCORE: 0.6438

HELIX: 0.0119

FCONS_SCORE: 1.0419

RIG_SCORE: 0.6357

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P3857T	TCGA-55-A490	LUAD	TCGA	VATPSST	DEG_SCF_FBW7_1	0.3056
p.G3848S	TCGA-77-8128	LUSC	TCGA	VATPSST	DEG_SCF_FBW7_1	0.2778
p.G3848S	TCGA-B5-A3FC	UCEC	TCGA	VATPSST	DEG_SCF_FBW7_1	0.2778
p.G3848S	TCGA-D1-A17Q	UCEC	TCGA	VATPSST	DEG_SCF_FBW7_1	0.2778
p.G3848S	SIDM00068	Colorectal Carcinoma	GDSC	VATPSST	DEG_SCF_FBW7_1	0.2778
p.G3848S	GEO	large_intestine	COSMIC	VATPSST	DEG_SCF_FBW7_1	0.2778
p.A3841V	TCGA-D9-A6EC	SKCM	TCGA	VATPSST	DEG_SCF_FBW7_1	0.0833
p.A3846V	TCGA-EE-A181	SKCM	TCGA	VATPSST	DEG_SCF_FBW7_1	0.2222
p.S3854Y	TCGA-EK-A3GK	CESC	TCGA	VATPSST	DEG_SCF_FBW7_1	0.6009
p.A3860V	TCGA-NH-A5IV	COAD	TCGA	VATPSST	DEG_SCF_FBW7_1	0.2222
p.S3857Y	DO49964	CESC	ICGC	VATPSST	DEG_SCF_FBW7_1	0.3056
p.A3863V	DO49095	COAD	ICGC	VATPSST	DEG_SCF_FBW7_1	0.5833
p.P3860T	DO24596	LUAD	ICGC	VATPSST	DEG_SCF_FBW7_1	0.2222
p.G3851S	DO26464	LUSC	ICGC	VATPSST	DEG_SCF_FBW7_1	0.6993
p.G3851S	DO41903	UCEC	ICGC	VATPSST	DEG_SCF_FBW7_1	0.6993
p.G3851S	DO41871	UCEC	ICGC	VATPSST	DEG_SCF_FBW7_1	0.6993
p.T3850I	DO220877	MELA	ICGC	VATPSST	DEG_SCF_FBW7_1	0.7078
p.A3849V	DO37444	SKCM	ICGC	VATPSST	DEG_SCF_FBW7_1	0.75
p.A3844V	DO50291	SKCM	ICGC	VATPSST	DEG_SCF_FBW7_1	0.1667
p.A3841T	SIDM00922	Non-Small Cell Lung Carcinoma	GDSC	VATPSST	DEG_SCF_FBW7_1	0.0833
p.A3846T	SIDM01045	Endometrial Carcinoma	GDSC	VATPSST	DEG_SCF_FBW7_1	0.2222
p.A3846T	SIDM01449	Pancreatic Carcinoma	GDSC	VATPSST	DEG_SCF_FBW7_1	0.2222
p.A3846T	ACH-000961	Endometrial/Uterine Cancer	CCLE	VATPSST	DEG_SCF_FBW7_1	0.2222
p.A3846T	ACH-000978	Endometrial/Uterine Cancer	CCLE	VATPSST	DEG_SCF_FBW7_1	0.2222
p.A3846T	EN	endometrium	COSMIC	VATPSST	DEG_SCF_FBW7_1	0.2222
p.P3853H	SIDM01064	Hodgkin's Lymphoma	GDSC	VATPSST	DEG_SCF_FBW7_1	0.7694
p.T3842I	SIDM00150	Colorectal Carcinoma	GDSC	VATPSST	DEG_SCF_FBW7_1	0.1111
p.T3842I	ACH-000969	Colon/Colorectal Cancer	CCLE	VATPSST	DEG_SCF_FBW7_1	0.1111
p.T3842I	KM12	large_intestine	COSMIC	VATPSST	DEG_SCF_FBW7_1	0.1111
p.T3852N	ACH-000252	Colon/Colorectal Cancer	CCLE	VATPSST	DEG_SCF_FBW7_1	0.8166

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VATPSST

Degron related mutations and impact score

Drug responses associated with MUC5B mutations

All proteins holding degron of VATPSST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI2	Connector enhancer of kinase suppressor of ras 2	DEG_SCF_FBW7_1	330:336	VATPSST	FBXW7	0.9917	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2036:2042	VATPSST	FBXW7	0.998	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2593:2599	VATPSST	FBXW7	0.9911	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3293:3299	VATPSST	FBXW7	0.9557	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3850:3856	VATPSST	FBXW7	0.993	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4578:4584	VATPSST	FBXW7	0.9844	More...