DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SCF_FBW7_1

Location: 2593:2599

E3 ligase: FBXW7

DEGRON score: 0.9911

ASA_SCORE: 90.1571

COIL: 0.94

CONS_SCORE: 0.2806

DSS_SCORE: 0.5961

HELIX: 0.0106

FCONS_SCORE: 1.0002

RIG_SCORE: 0.6606

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2596S	TCGA-05-4389	LUAD	TCGA	VATPSST	DEG_SCF_FBW7_1	0.6752
p.P2596T	TCGA-CV-A45Z	HNSC	TCGA	VATPSST	DEG_SCF_FBW7_1	0.7031
p.A2597V	DO225276	BRCA	ICGC	VATPSST	DEG_SCF_FBW7_1	0.6936
p.A2597V	DO224802	BRCA	ICGC	VATPSST	DEG_SCF_FBW7_1	0.6936
p.G2591R	DO227975	COCA	ICGC	VATPSST	DEG_SCF_FBW7_1	0.2778
p.G2591R	DO224761	COCA	ICGC	VATPSST	DEG_SCF_FBW7_1	0.2778
p.G2591R	DO51019	LAML	ICGC	VATPSST	DEG_SCF_FBW7_1	0.2778
p.G2591R	DO229061	LICA	ICGC	VATPSST	DEG_SCF_FBW7_1	0.2778
p.G2591R	DO229006	LICA	ICGC	VATPSST	DEG_SCF_FBW7_1	0.2778
p.G2591R	DO229259	THCA	ICGC	VATPSST	DEG_SCF_FBW7_1	0.2778
p.P2599T	DO52064	HNSC	ICGC	VATPSST	DEG_SCF_FBW7_1	0.7031
p.P2599S	DO24307	LUAD	ICGC	VATPSST	DEG_SCF_FBW7_1	0.6752
p.T2585N	DO218922	LUAD	ICGC	VATPSST	DEG_SCF_FBW7_1	0.1111
p.T2585N	DO219209	LUSC	ICGC	VATPSST	DEG_SCF_FBW7_1	0.1111
p.A2594S	SIDM00261	Ewing's Sarcoma	GDSC	VATPSST	DEG_SCF_FBW7_1	0.6477
p.A2594S	ACH-002109	Bone Cancer	CCLE	VATPSST	DEG_SCF_FBW7_1	0.6477
p.A2594S	ES8	bone	COSMIC	VATPSST	DEG_SCF_FBW7_1	0.6477

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI2	Connector enhancer of kinase suppressor of ras 2	DEG_SCF_FBW7_1	330:336	VATPSST	FBXW7	0.9917	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2036:2042	VATPSST	FBXW7	0.998	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	2593:2599	VATPSST	FBXW7	0.9911	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3293:3299	VATPSST	FBXW7	0.9557	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	3850:3856	VATPSST	FBXW7	0.993	More...
Q9HC84	Mucin-5B	DEG_SCF_FBW7_1	4578:4584	VATPSST	FBXW7	0.9844	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons