DegronMD

Uniprot ID: Q8WXI2

Source protein: Connector enhancer of kinase suppressor of ras 2

Source gene: CNKSR2

Class: DEG_SPOP_SBC_1

Location: 775:779

E3 ligase: SPOP

DEGRON score: 0.8711

ASA_SCORE: 78.76

COIL: 0.875

CONS_SCORE: 0.4724

DSS_SCORE: 0.3051

HELIX: 0.0812

FCONS_SCORE: 1.1456

RIG_SCORE: 0.7354

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q769H	TCGA-37-4135	LUSC	TCGA	PLTSS	DEG_SPOP_SBC_1	0.1667
p.Q769H	TCGA-94-8035	LUSC	TCGA	PLTSS	DEG_SPOP_SBC_1	0.1667
p.Q769H	DO233865	GACA	ICGC	PLTSS	DEG_SPOP_SBC_1	0.1667
p.P775S	TCGA-78-8640	LUAD	TCGA	PLTSS	DEG_SPOP_SBC_1	0.6752
p.P788S	TCGA-G4-6628	COAD	TCGA	PLTSS	DEG_SPOP_SBC_1	0.0833
p.P788S	SIDM00783	Colorectal Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	0.0833
p.P788S	ACH-000971	Colon/Colorectal Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	0.0833
p.P788S	HCT-116	large_intestine	COSMIC	PLTSS	DEG_SPOP_SBC_1	0.0833
p.R766H	DO222746	COCA	ICGC	PLTSS	DEG_SPOP_SBC_1	0.0833
p.R766H	SIDM00596	Endometrial Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	0.0833
p.R766H	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PLTSS	DEG_SPOP_SBC_1	0.0833
p.R766H	ACH-000937	Leukemia	CCLE	PLTSS	DEG_SPOP_SBC_1	0.0833
p.R766H	ACH-001517	Endometrial/Uterine Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	0.0833
p.R766H	HEC-1	endometrium	COSMIC	PLTSS	DEG_SPOP_SBC_1	0.0833
p.R766H	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	PLTSS	DEG_SPOP_SBC_1	0.0833
p.L786Q	DO26530	LUSC	ICGC	PLTSS	DEG_SPOP_SBC_1	0.1389
p.R782K	DO222550	MELA	ICGC	PLTSS	DEG_SPOP_SBC_1	0.25
p.P776T	DO47353	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	0.7031
p.E779K	DO37931	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	0.7022
p.G788E	DO38111	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	0.0833
p.C766Y	DO41235	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	0.0833
p.D770N	SIDM00007	Other Solid Cancers	GDSC	PLTSS	DEG_SPOP_SBC_1	0.1944
p.D770N	ACH-001550	Skin Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	0.1944
p.W768L	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	0.1389
p.W768L	ACH-000452	Esophageal Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	0.1389
p.W768L	TE-8	oesophagus	COSMIC	PLTSS	DEG_SPOP_SBC_1	0.1389
p.I770V	NCI-H1915	lung	COSMIC	PLTSS	DEG_SPOP_SBC_1	0.1944
p.I770V	CAL-39	vulva	COSMIC	PLTSS	DEG_SPOP_SBC_1	0.1944
p.Q789E	NCI-H2342	lung	COSMIC	PLTSS	DEG_SPOP_SBC_1	0.0556
p.A768V	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PLTSS	DEG_SPOP_SBC_1	0.1389
p.I775V	NCI-H1915	lung	COSMIC	PLTSS	DEG_SPOP_SBC_1	0.7076
p.I775V	CAL-39	vulva	COSMIC	PLTSS	DEG_SPOP_SBC_1	0.7076
p.Q785E	NCI-H2342	lung	COSMIC	PLTSS	DEG_SPOP_SBC_1	0.1667
p.H779R	SK-MEL-24	skin	COSMIC	PLTSS	DEG_SPOP_SBC_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43586	Proline-serine-threonine phosphatase-interacting protein 1	DEG_SPOP_SBC_1	294:298	PLTSS	SPOP	0.9863	More...
O60284	Suppression of tumorigenicity 18 protein	DEG_SPOP_SBC_1	629:633	PLTSS	SPOP	0.9793	More...
O75563	Src kinase-associated phosphoprotein 2	DEG_SPOP_SBC_1	249:253	PLTSS	SPOP	0.9972	More...
O95486	Protein transport protein Sec24A	DEG_SPOP_SBC_1	226:230	PLTSS	SPOP	0.9934	More...
P15941	Mucin-1	DEG_SPOP_SBC_1	1024:1028	PLTSS	SPOP	0.8767	More...
P49736	DNA replication licensing factor MCM2	DEG_SPOP_SBC_1	23:27	PLTSS	SPOP	0.9038	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1038:1042	PLTSS	SPOP	0.6344	More...
Q15475	Homeobox protein SIX1	DEG_SPOP_SBC_1	274:278	PLTSS	SPOP	0.5507	More...
Q15691	Microtubule-associated protein RP/EB family member 1	DEG_SPOP_SBC_1	152:156	PLTSS	SPOP	0.9872	More...
Q17RY0	Cytoplasmic polyadenylation element-binding protein 4	DEG_SPOP_SBC_1	157:161	PLTSS	SPOP	0.9878	More...
Q5HYW2	NHS-like protein 2	DEG_SPOP_SBC_1	774:778	PLTSS	SPOP	0.9452	More...
Q69YQ0	Cytospin-A	DEG_SPOP_SBC_1	355:359	PLTSS	SPOP	0.9297	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	254:258	PLTSS	SPOP	0.949	More...
Q7Z434	Mitochondrial antiviral-signaling protein	DEG_SPOP_SBC_1	189:193	PLTSS	SPOP	0.9989	More...
Q8NEP3	Dynein axonemal assembly factor 1	DEG_SPOP_SBC_1	671:675	PLTSS	SPOP	0.9436	More...
Q8WXI2	Connector enhancer of kinase suppressor of ras 2	DEG_SPOP_SBC_1	775:779	PLTSS	SPOP	0.8711	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1750:1754	PLTSS	SPOP	0.9632	More...
Q96RU2	Ubiquitin carboxyl-terminal hydrolase 28	DEG_SPOP_SBC_1	514:518	PLTSS	SPOP	0.9579	More...
Q96RW7	Hemicentin-1	DEG_SPOP_SBC_1	2817:2821	PLTSS	SPOP	0.5877	More...
Q99633	Pre-mRNA-splicing factor 18	DEG_SPOP_SBC_1	58:62	PLTSS	SPOP	0.9188	More...
Q9BZE9	Tether containing UBX domain for GLUT4	DEG_SPOP_SBC_1	261:265	PLTSS	SPOP	0.9718	More...
Q9C0B0	RING finger protein unkempt homolog	DEG_SPOP_SBC_1	468:472	PLTSS	SPOP	0.7927	More...
Q9NPI1	Bromodomain-containing protein 7	DEG_SPOP_SBC_1	120:124	PLTSS	SPOP	0.9763	More...
Q9UDV6	Zinc finger protein 212	DEG_SPOP_SBC_1	17:21	PLTSS	SPOP	0.99	More...
Q9UHK0	Nuclear fragile X mental retardation-interacting protein 1	DEG_SPOP_SBC_1	49:53	PLTSS	SPOP	0.9611	More...
Q6ZMY3	SPOC domain-containing protein 1	DEG_SPOP_SBC_1	193:197	PLTSS	SPOP	0.8764	More...
Q8IWR0	Zinc finger CCCH domain-containing protein 7A	DEG_SPOP_SBC_1	347:351	PLTSS	SPOP	0.9188	More...
O94880	PHD finger protein 14	DEG_SPOP_SBC_1	568:572	PLTSS	SPOP	0.9962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLTSS

Degron related mutations and impact score

Drug responses associated with CNKSR2 mutations

All proteins holding degron of PLTSS