DegronMD - O95486(SEC24A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G269C	TCGA-55-8620	LUAD	TCGA	LLATPQLT	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.2778
p.G269C	DO24547	LUAD	ICGC	LLATPQLT	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.2778
p.Q114H	TCGA-86-7954	LUAD	TCGA	PATTPMPS	DEG_SCF_FBW7_1	116:123	Mutation rewiring degron network	0.2778
p.Q114H	DO23660	LUAD	ICGC	PATTPMPS	DEG_SCF_FBW7_1	116:123	Mutation rewiring degron network	0.2778
p.R286Q	TCGA-A5-A1OF	UCEC	TCGA	LLATPQLT	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.1111
p.R286Q	TCGA-A5-A1OF	UCEC	TCGA	PPGY	ITCH	296:299	Mutation rewiring degron network	0.0556
p.R286Q	TCGA-AX-A2HC	UCEC	TCGA	LLATPQLT	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.1111
p.R286Q	TCGA-AX-A2HC	UCEC	TCGA	PPGY	ITCH	296:299	Mutation rewiring degron network	0.0556
p.R286Q	DO41572	UCEC	ICGC	LLATPQLT	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.1111
p.R286Q	DO41572	UCEC	ICGC	PPGY	ITCH	296:299	Mutation rewiring degron network	0.0556
p.R286Q	DO42568	UCEC	ICGC	LLATPQLT	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.1111
p.R286Q	DO42568	UCEC	ICGC	PPGY	ITCH	296:299	Mutation rewiring degron network	0.0556
p.D264N	TCGA-AA-A010	COAD	TCGA	LLATPQLT	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.1389
p.F239Y	TCGA-CZ-5468	KIRC	TCGA	LTPLTS	DEG_SCF_FBW7_1	224:229	Mutation rewiring degron network	0.0556
p.F239Y	TCGA-CZ-5468	KIRC	TCGA	PLTSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.0833
p.F239Y	DO18332	KIRC	ICGC	LTPLTS	DEG_SCF_FBW7_1	224:229	Mutation rewiring degron network	0.0556
p.F239Y	DO18332	KIRC	ICGC	PLTSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.0833
p.Q236K	TCGA-D3-A2JP	SKCM	TCGA	LTPLTS	DEG_SCF_FBW7_1	224:229	Mutation rewiring degron network	0.1389
p.Q236K	TCGA-D3-A2JP	SKCM	TCGA	PLTSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1667
p.Q236K	DO47407	SKCM	ICGC	LTPLTS	DEG_SCF_FBW7_1	224:229	Mutation rewiring degron network	0.1389
p.Q236K	DO47407	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1667
p.P218Q	TCGA-D9-A6E9	SKCM	TCGA	LTPLTS	DEG_SCF_FBW7_1	224:229	Mutation rewiring degron network	0.1667
p.P218Q	TCGA-D9-A6E9	SKCM	TCGA	PLTSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1111
p.P218Q	DO50289	SKCM	ICGC	LTPLTS	DEG_SCF_FBW7_1	224:229	Mutation rewiring degron network	0.1667
p.P218Q	DO50289	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1111
p.L271S	TCGA-EE-A2MS	SKCM	TCGA	LLATPQLT	DEG_SCF_FBW7_1	271:278	Mutation altering degron motif	0.7667
p.L271S	DO37567	SKCM	ICGC	LLATPQLT	DEG_SCF_FBW7_1	271:278	Mutation altering degron motif	0.7667
p.P220S	TCGA-EE-A3AH	SKCM	TCGA	LTPLTS	DEG_SCF_FBW7_1	224:229	Mutation rewiring degron network	0.2222
p.P220S	TCGA-EE-A3AH	SKCM	TCGA	PLTSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1667
p.P220S	DO222635	MELA	ICGC	LTPLTS	DEG_SCF_FBW7_1	224:229	Mutation rewiring degron network	0.2222
p.P220S	DO222635	MELA	ICGC	PLTSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1667
p.P220S	DO37443	SKCM	ICGC	LTPLTS	DEG_SCF_FBW7_1	224:229	Mutation rewiring degron network	0.2222
p.P220S	DO37443	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1667
p.G309V	TCGA-ER-A195	SKCM	TCGA	PPGY	ITCH	296:299	Mutation rewiring degron network	0.0556
p.G309V	DO47712	SKCM	ICGC	PPGY	ITCH	296:299	Mutation rewiring degron network	0.0556
p.A223V	TCGA-F7-A624	HNSC	TCGA	LTPLTS	DEG_SCF_FBW7_1	224:229	Mutation rewiring degron network	0.3056
p.A223V	TCGA-F7-A624	HNSC	TCGA	PLTSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.25
p.A223V	DO44440	HNSC	ICGC	LTPLTS	DEG_SCF_FBW7_1	224:229	Mutation rewiring degron network	0.3056
p.A223V	DO44440	HNSC	ICGC	PLTSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.25
p.A223V	DO50962	LICA	ICGC	LTPLTS	DEG_SCF_FBW7_1	224:229	Mutation rewiring degron network	0.3056
p.A223V	DO50962	LICA	ICGC	PLTSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.25
p.P383L	TCGA-FR-A726	SKCM	TCGA	FRCTLTSIP	DEG_APCC_DBOX_1	386:394	Mutation rewiring degron network	0.25
p.P383L	DO48665	SKCM	ICGC	FRCTLTSIP	DEG_APCC_DBOX_1	386:394	Mutation rewiring degron network	0.25
p.K378I	TCGA-FS-A1ZZ	SKCM	TCGA	FRCTLTSIP	DEG_APCC_DBOX_1	386:394	Mutation substituting flanking lysine	0.2222
p.K378I	DO37412	SKCM	ICGC	FRCTLTSIP	DEG_APCC_DBOX_1	386:394	Mutation substituting flanking lysine	0.2222
p.P383Q	TCGA-GN-A262	SKCM	TCGA	FRCTLTSIP	DEG_APCC_DBOX_1	386:394	Mutation rewiring degron network	0.25
p.P383Q	DO37515	SKCM	ICGC	FRCTLTSIP	DEG_APCC_DBOX_1	386:394	Mutation rewiring degron network	0.25
p.R222M	TCGA-GN-A26C	SKCM	TCGA	LTPLTS	DEG_SCF_FBW7_1	224:229	Mutation rewiring degron network	0.2778
p.R222M	TCGA-GN-A26C	SKCM	TCGA	PLTSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.2222
p.R222M	DO37782	SKCM	ICGC	LTPLTS	DEG_SCF_FBW7_1	224:229	Mutation rewiring degron network	0.2778
p.R222M	DO37782	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.2222
p.A398T	TCGA-LC-A66R	BLCA	TCGA	FRCTLTSIP	DEG_APCC_DBOX_1	386:394	Mutation rewiring degron network	0.2222
p.A398T	DO44031	BLCA	ICGC	FRCTLTSIP	DEG_APCC_DBOX_1	386:394	Mutation rewiring degron network	0.2222
p.Q236R	TCGA-QS-A5YR	UCEC	TCGA	LTPLTS	DEG_SCF_FBW7_1	224:229	Mutation rewiring degron network	0.1389
p.Q236R	TCGA-QS-A5YR	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1667
p.Q236R	DO50081	UCEC	ICGC	LTPLTS	DEG_SCF_FBW7_1	224:229	Mutation rewiring degron network	0.1389
p.Q236R	DO50081	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1667
p.K404N	TCGA-VQ-A8P2	STAD	TCGA	FRCTLTSIP	DEG_APCC_DBOX_1	386:394	Mutation blocking ubiquitination signal	0.5
p.K404N	DO51761	STAD	ICGC	FRCTLTSIP	DEG_APCC_DBOX_1	386:394	Mutation blocking ubiquitination signal	0.5
p.S123F	TCGA-VS-A8EI	CESC	TCGA	PATTPMPS	DEG_SCF_FBW7_1	116:123	Mutation altering degron motif	0.7982
p.S123F	DO51621	CESC	ICGC	PATTPMPS	DEG_SCF_FBW7_1	116:123	Mutation altering degron motif	0.7982
p.E265K	TCGA-Z6-AAPN	ESCA	TCGA	LLATPQLT	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.1667
p.G269D	DO229050	LICA	ICGC	LLATPQLT	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.2778
p.C381F	DO229052	LICA	ICGC	FRCTLTSIP	DEG_APCC_DBOX_1	386:394	Mutation rewiring degron network	0.1944
p.C381F	DO229009	LICA	ICGC	FRCTLTSIP	DEG_APCC_DBOX_1	386:394	Mutation rewiring degron network	0.1944
p.K404R	DO23266	LINC	ICGC	FRCTLTSIP	DEG_APCC_DBOX_1	386:394	Mutation blocking ubiquitination signal	0.5
p.P133Q	DO38404	STAD	ICGC	PATTPMPS	DEG_SCF_FBW7_1	116:123	Mutation rewiring degron network	0.0556
p.P305A	SIDM01265	Plasma Cell Myeloma	GDSC	PPGY	ITCH	296:299	Mutation rewiring degron network	0.1667
p.P305A	SIDM00773	Non-Cancerous	GDSC	PPGY	ITCH	296:299	Mutation rewiring degron network	0.1667
p.P305A	SIDM01126	Small Cell Lung Carcinoma	GDSC	PPGY	ITCH	296:299	Mutation rewiring degron network	0.1667
p.P305A	SIDM00087	Plasma Cell Myeloma	GDSC	PPGY	ITCH	296:299	Mutation rewiring degron network	0.1667
p.P305A	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PPGY	ITCH	296:299	Mutation rewiring degron network	0.1667
p.P305A	SIDM00971	Breast Carcinoma	GDSC	PPGY	ITCH	296:299	Mutation rewiring degron network	0.1667
p.P305A	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	PPGY	ITCH	296:299	Mutation rewiring degron network	0.1667
p.P305A	SIDM00844	Burkitt's Lymphoma	GDSC	PPGY	ITCH	296:299	Mutation rewiring degron network	0.1667
p.P305A	SIDM00068	Colorectal Carcinoma	GDSC	PPGY	ITCH	296:299	Mutation rewiring degron network	0.1667
p.P305A	SIDM00774	Breast Carcinoma	GDSC	PPGY	ITCH	296:299	Mutation rewiring degron network	0.1667
p.T389M	SIDM01169	Ovarian Carcinoma	GDSC	FRCTLTSIP	DEG_APCC_DBOX_1	386:394	Mutation altering degron motif	0.7423
p.T389M	ACH-000885	Ovarian Cancer	CCLE	FRCTLTSIP	DEG_APCC_DBOX_1	386:394	Mutation altering degron motif	0.7423
p.T389M	TOV-21G	ovary	COSMIC	FRCTLTSIP	DEG_APCC_DBOX_1	386:394	Mutation altering degron motif	0.7423
p.P220Q	SIDM01117	Small Cell Lung Carcinoma	GDSC	LTPLTS	DEG_SCF_FBW7_1	224:229	Mutation rewiring degron network	0.2222
p.P220Q	SIDM01117	Small Cell Lung Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1667
p.S285N	SIDM00082	Melanoma	GDSC	LLATPQLT	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.1389
p.K283N	SIDM00193	Colorectal Carcinoma	GDSC	LLATPQLT	DEG_SCF_FBW7_1	271:278	Mutation substituting flanking lysine	0.3056
p.K283N	ACH-000991	Colon/Colorectal Cancer	CCLE	LLATPQLT	DEG_SCF_FBW7_1	271:278	Mutation substituting flanking lysine	0.3056
p.K283N	SNU-81	large intestine	COSMIC	LLATPQLT	DEG_SCF_FBW7_1	271:278	Mutation substituting flanking lysine	0.3056
p.L238V	SIDM00910	Neuroblastoma	GDSC	LTPLTS	DEG_SCF_FBW7_1	224:229	Mutation rewiring degron network	0.0833
p.L238V	SIDM00910	Neuroblastoma	GDSC	PLTSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1111
p.L238V	CHP-212	autonomic ganglia	COSMIC	LTPLTS	DEG_SCF_FBW7_1	224:229	Mutation rewiring degron network	0.0833
p.L238V	CHP-212	autonomic ganglia	COSMIC	PLTSS	DEG_SPOP_SBC_1	226:230	Mutation rewiring degron network	0.1111
p.M108V	SIDM00863	Burkitt's Lymphoma	GDSC	PATTPMPS	DEG_SCF_FBW7_1	116:123	Mutation rewiring degron network	0.1111
p.M108V	ACH-000877	Lymphoma	CCLE	PATTPMPS	DEG_SCF_FBW7_1	116:123	Mutation rewiring degron network	0.1111
p.M108V	ACH-001064	Lymphoma	CCLE	PATTPMPS	DEG_SCF_FBW7_1	116:123	Mutation rewiring degron network	0.1111
p.M108V	EB2	haematopoietic and lymphoid tissue	COSMIC	PATTPMPS	DEG_SCF_FBW7_1	116:123	Mutation rewiring degron network	0.1111
p.S261G	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	LLATPQLT	DEG_SCF_FBW7_1	271:278	Mutation rewiring degron network	0.0556
p.L224P	ACH-000391	Bone Cancer	CCLE	LTPLTS	DEG_SCF_FBW7_1	224:229	Mutation altering degron motif	0.6471
p.L224P	MHH-ES-1	bone	COSMIC	LTPLTS	DEG_SCF_FBW7_1	224:229	Mutation altering degron motif	0.6471

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SEC24A

UniProt ID: O95486

Entrez ID: 10802

Protein name: Protein transport protein Sec24A (SEC24-related protein A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SEC24A in