DegronMD

Uniprot ID: O95486

Source protein: Protein transport protein Sec24A

Source gene: SEC24A

Class: DEG_SCF_FBW7_1

Location: 224:229

E3 ligase: FBXW7

DEGRON score: 0.9917

ASA_SCORE: 88.5167

COIL: 0.9563

CONS_SCORE: 0.2281

DSS_SCORE: 0.6146

HELIX: 0.0287

FCONS_SCORE: 0.755

RIG_SCORE: 0.7027

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F239Y	TCGA-CZ-5468	KIRC	TCGA	LTPLTS	DEG_SCF_FBW7_1	0.0556
p.F239Y	DO18332	KIRC	ICGC	LTPLTS	DEG_SCF_FBW7_1	0.0556
p.Q236K	TCGA-D3-A2JP	SKCM	TCGA	LTPLTS	DEG_SCF_FBW7_1	0.1389
p.Q236K	DO47407	SKCM	ICGC	LTPLTS	DEG_SCF_FBW7_1	0.1389
p.P218Q	TCGA-D9-A6E9	SKCM	TCGA	LTPLTS	DEG_SCF_FBW7_1	0.1667
p.P218Q	DO50289	SKCM	ICGC	LTPLTS	DEG_SCF_FBW7_1	0.1667
p.P220S	TCGA-EE-A3AH	SKCM	TCGA	LTPLTS	DEG_SCF_FBW7_1	0.2222
p.P220S	DO222635	MELA	ICGC	LTPLTS	DEG_SCF_FBW7_1	0.2222
p.P220S	DO37443	SKCM	ICGC	LTPLTS	DEG_SCF_FBW7_1	0.2222
p.A223V	TCGA-F7-A624	HNSC	TCGA	LTPLTS	DEG_SCF_FBW7_1	0.3056
p.A223V	DO44440	HNSC	ICGC	LTPLTS	DEG_SCF_FBW7_1	0.3056
p.A223V	DO50962	LICA	ICGC	LTPLTS	DEG_SCF_FBW7_1	0.3056
p.R222M	TCGA-GN-A26C	SKCM	TCGA	LTPLTS	DEG_SCF_FBW7_1	0.2778
p.R222M	DO37782	SKCM	ICGC	LTPLTS	DEG_SCF_FBW7_1	0.2778
p.Q236R	TCGA-QS-A5YR	UCEC	TCGA	LTPLTS	DEG_SCF_FBW7_1	0.1389
p.Q236R	DO50081	UCEC	ICGC	LTPLTS	DEG_SCF_FBW7_1	0.1389
p.P220Q	SIDM01117	Small Cell Lung Carcinoma	GDSC	LTPLTS	DEG_SCF_FBW7_1	0.2222
p.L238V	SIDM00910	Neuroblastoma	GDSC	LTPLTS	DEG_SCF_FBW7_1	0.0833
p.L238V	CHP-212	autonomic_ganglia	COSMIC	LTPLTS	DEG_SCF_FBW7_1	0.0833
p.L224P	ACH-000391	Bone Cancer	CCLE	LTPLTS	DEG_SCF_FBW7_1	0.6471
p.L224P	MHH-ES-1	bone	COSMIC	LTPLTS	DEG_SCF_FBW7_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95486	Protein transport protein Sec24A	DEG_SCF_FBW7_1	224:229	LTPLTS	FBXW7	0.9917	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons