DegronMD

Uniprot ID: O95486

Source protein: Protein transport protein Sec24A

Source gene: SEC24A

Class: DEG_APCC_DBOX_1

Location: 386:394

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6109

ASA_SCORE: 24.7333

COIL: 0.4858

CONS_SCORE: 0.5963

DSS_SCORE: 0.153

HELIX: 0.2367

FCONS_SCORE: 1.3349

RIG_SCORE: 0.8524

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P383L	TCGA-FR-A726	SKCM	TCGA	FRCTLTSIP	DEG_APCC_DBOX_1	0.25
p.P383L	DO48665	SKCM	ICGC	FRCTLTSIP	DEG_APCC_DBOX_1	0.25
p.K378I	TCGA-FS-A1ZZ	SKCM	TCGA	FRCTLTSIP	DEG_APCC_DBOX_1	0.2222
p.K378I	DO37412	SKCM	ICGC	FRCTLTSIP	DEG_APCC_DBOX_1	0.2222
p.P383Q	TCGA-GN-A262	SKCM	TCGA	FRCTLTSIP	DEG_APCC_DBOX_1	0.25
p.P383Q	DO37515	SKCM	ICGC	FRCTLTSIP	DEG_APCC_DBOX_1	0.25
p.A398T	TCGA-LC-A66R	BLCA	TCGA	FRCTLTSIP	DEG_APCC_DBOX_1	0.2222
p.A398T	DO44031	BLCA	ICGC	FRCTLTSIP	DEG_APCC_DBOX_1	0.2222
p.K404N	TCGA-VQ-A8P2	STAD	TCGA	FRCTLTSIP	DEG_APCC_DBOX_1	0.5
p.K404N	DO51761	STAD	ICGC	FRCTLTSIP	DEG_APCC_DBOX_1	0.5
p.C381F	DO229052	LICA	ICGC	FRCTLTSIP	DEG_APCC_DBOX_1	0.1944
p.C381F	DO229009	LICA	ICGC	FRCTLTSIP	DEG_APCC_DBOX_1	0.1944
p.K404R	DO23266	LINC	ICGC	FRCTLTSIP	DEG_APCC_DBOX_1	0.5
p.T389M	SIDM01169	Ovarian Carcinoma	GDSC	FRCTLTSIP	DEG_APCC_DBOX_1	0.7423
p.T389M	ACH-000885	Ovarian Cancer	CCLE	FRCTLTSIP	DEG_APCC_DBOX_1	0.7423
p.T389M	TOV-21G	ovary	COSMIC	FRCTLTSIP	DEG_APCC_DBOX_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95486	Protein transport protein Sec24A	DEG_APCC_DBOX_1	386:394	FRCTLTSIP	APC,CDC20,FZR1	0.6109	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons