DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
FRCTLTSIP
Uniprot ID:
O95486
Source protein:
Protein transport protein Sec24A
Source gene:
SEC24A
Class:
DEG_APCC_DBOX_1
Location:
386:394
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6109
ASA_SCORE:
24.7333
COIL:
0.4858
CONS_SCORE:
0.5963
DSS_SCORE:
0.153
HELIX:
0.2367
FCONS_SCORE:
1.3349
RIG_SCORE:
0.8524
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T389M
SIDM01169
Ovarian Carcinoma
GDSC
FRCTLTSIP
DEG_APCC_DBOX_1
0.7423
p.T389M
ACH-000885
Ovarian Cancer
CCLE
FRCTLTSIP
DEG_APCC_DBOX_1
0.7423
p.T389M
TOV-21G
ovary
COSMIC
FRCTLTSIP
DEG_APCC_DBOX_1
0.7423
p.K404N
TCGA-VQ-A8P2
STAD
TCGA
FRCTLTSIP
DEG_APCC_DBOX_1
0.5
p.K404N
DO51761
STAD
ICGC
FRCTLTSIP
DEG_APCC_DBOX_1
0.5
p.K404R
DO23266
LINC
ICGC
FRCTLTSIP
DEG_APCC_DBOX_1
0.5
p.P383L
TCGA-FR-A726
SKCM
TCGA
FRCTLTSIP
DEG_APCC_DBOX_1
0.25
p.P383L
DO48665
SKCM
ICGC
FRCTLTSIP
DEG_APCC_DBOX_1
0.25
p.P383Q
TCGA-GN-A262
SKCM
TCGA
FRCTLTSIP
DEG_APCC_DBOX_1
0.25
p.P383Q
DO37515
SKCM
ICGC
FRCTLTSIP
DEG_APCC_DBOX_1
0.25
p.K378I
TCGA-FS-A1ZZ
SKCM
TCGA
FRCTLTSIP
DEG_APCC_DBOX_1
0.2222
p.K378I
DO37412
SKCM
ICGC
FRCTLTSIP
DEG_APCC_DBOX_1
0.2222
p.A398T
TCGA-LC-A66R
BLCA
TCGA
FRCTLTSIP
DEG_APCC_DBOX_1
0.2222
p.A398T
DO44031
BLCA
ICGC
FRCTLTSIP
DEG_APCC_DBOX_1
0.2222
p.C381F
DO229052
LICA
ICGC
FRCTLTSIP
DEG_APCC_DBOX_1
0.1944
p.C381F
DO229009
LICA
ICGC
FRCTLTSIP
DEG_APCC_DBOX_1
0.1944
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Drug responses associated with SEC24A mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of FRCTLTSIP
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95486
Protein transport protein Sec24A
DEG_APCC_DBOX_1
386:394
FRCTLTSIP
APC,CDC20,FZR1
0.6109
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