DegronMD

Uniprot ID: O95486

Source protein: Protein transport protein Sec24A

Source gene: SEC24A

Class: DEG_SCF_FBW7_1

Location: 116:123

E3 ligase: FBXW7

DEGRON score: 0.9875

ASA_SCORE: 84

COIL: 0.9635

CONS_SCORE: 0.258

DSS_SCORE: 0.6492

HELIX: 0.0214

FCONS_SCORE: 0.9582

RIG_SCORE: 0.5896

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q114H	TCGA-86-7954	LUAD	TCGA	PATTPMPS	DEG_SCF_FBW7_1	0.2778
p.Q114H	DO23660	LUAD	ICGC	PATTPMPS	DEG_SCF_FBW7_1	0.2778
p.S123F	TCGA-VS-A8EI	CESC	TCGA	PATTPMPS	DEG_SCF_FBW7_1	0.7982
p.S123F	DO51621	CESC	ICGC	PATTPMPS	DEG_SCF_FBW7_1	0.7982
p.P133Q	DO38404	STAD	ICGC	PATTPMPS	DEG_SCF_FBW7_1	0.0556
p.M108V	SIDM00863	Burkitt's Lymphoma	GDSC	PATTPMPS	DEG_SCF_FBW7_1	0.1111
p.M108V	ACH-000877	Lymphoma	CCLE	PATTPMPS	DEG_SCF_FBW7_1	0.1111
p.M108V	ACH-001064	Lymphoma	CCLE	PATTPMPS	DEG_SCF_FBW7_1	0.1111
p.M108V	EB2	haematopoietic_and_lymphoid_tissue	COSMIC	PATTPMPS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95486	Protein transport protein Sec24A	DEG_SCF_FBW7_1	116:123	PATTPMPS	FBXW7	0.9875	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons