DegronMD

Uniprot ID: O95486

Source protein: Protein transport protein Sec24A

Source gene: SEC24A

Class: DEG_SCF_FBW7_1

Location: 271:278

E3 ligase: FBXW7

DEGRON score: 0.973

ASA_SCORE: 84.875

COIL: 0.9346

CONS_SCORE: 0.2499

DSS_SCORE: 0.5311

HELIX: 0.0261

FCONS_SCORE: 0.9487

RIG_SCORE: 0.7447

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G269C	TCGA-55-8620	LUAD	TCGA	LLATPQLT	DEG_SCF_FBW7_1	0.2778
p.G269C	DO24547	LUAD	ICGC	LLATPQLT	DEG_SCF_FBW7_1	0.2778
p.R286Q	TCGA-A5-A1OF	UCEC	TCGA	LLATPQLT	DEG_SCF_FBW7_1	0.1111
p.R286Q	TCGA-AX-A2HC	UCEC	TCGA	LLATPQLT	DEG_SCF_FBW7_1	0.1111
p.R286Q	DO41572	UCEC	ICGC	LLATPQLT	DEG_SCF_FBW7_1	0.1111
p.R286Q	DO42568	UCEC	ICGC	LLATPQLT	DEG_SCF_FBW7_1	0.1111
p.D264N	TCGA-AA-A010	COAD	TCGA	LLATPQLT	DEG_SCF_FBW7_1	0.1389
p.L271S	TCGA-EE-A2MS	SKCM	TCGA	LLATPQLT	DEG_SCF_FBW7_1	0.7667
p.L271S	DO37567	SKCM	ICGC	LLATPQLT	DEG_SCF_FBW7_1	0.7667
p.E265K	TCGA-Z6-AAPN	ESCA	TCGA	LLATPQLT	DEG_SCF_FBW7_1	0.1667
p.G269D	DO229050	LICA	ICGC	LLATPQLT	DEG_SCF_FBW7_1	0.2778
p.S285N	SIDM00082	Melanoma	GDSC	LLATPQLT	DEG_SCF_FBW7_1	0.1389
p.K283N	SIDM00193	Colorectal Carcinoma	GDSC	LLATPQLT	DEG_SCF_FBW7_1	0.3056
p.K283N	ACH-000991	Colon/Colorectal Cancer	CCLE	LLATPQLT	DEG_SCF_FBW7_1	0.3056
p.K283N	SNU-81	large_intestine	COSMIC	LLATPQLT	DEG_SCF_FBW7_1	0.3056
p.S261G	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	LLATPQLT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95486	Protein transport protein Sec24A	DEG_SCF_FBW7_1	271:278	LLATPQLT	FBXW7	0.973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons