DegronMD - Q96RW7(HMCN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A546V	TCGA-2W-A8YY	CESC	TCGA	ERAVLTCLI	DEG_APCC_DBOX_1	535:543	Mutation rewiring degron network	0.25
p.A546V	DO223732	CESC	ICGC	ERAVLTCLI	DEG_APCC_DBOX_1	535:543	Mutation rewiring degron network	0.25
p.G2517V	TCGA-39-5016	LUSC	TCGA	EVTGNPVPEI	DEG_COP1_1	2502:2511	Mutation rewiring degron network	0.1667
p.G2517V	DO26701	LUSC	ICGC	EVTGNPVPEI	DEG_COP1_1	2502:2511	Mutation rewiring degron network	0.1667
p.G3809S	TCGA-55-8204	LUAD	TCGA	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	3806:3819	Mutation altering degron motif	0.5882
p.G3809S	DO45322	LUAD	ICGC	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	3806:3819	Mutation altering degron motif	0.5882
p.G3829V	TCGA-64-5781	LUAD	TCGA	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	3806:3819	Mutation rewiring degron network	0.0556
p.G3829V	DO23740	LUAD	ICGC	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	3806:3819	Mutation rewiring degron network	0.0556
p.Q3799H	TCGA-69-7979	LUAD	TCGA	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	3806:3819	Mutation rewiring degron network	0.1389
p.Q3799H	DO23874	LUAD	ICGC	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	3806:3819	Mutation rewiring degron network	0.1389
p.T2498M	TCGA-AP-A0LM	UCEC	TCGA	EVTGNPVPEI	DEG_COP1_1	2502:2511	Mutation rewiring degron network	0.2222
p.T2498M	DO43306	UCEC	ICGC	EVTGNPVPEI	DEG_COP1_1	2502:2511	Mutation rewiring degron network	0.2222
p.P3804L	TCGA-CV-7568	HNSC	TCGA	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	3806:3819	Mutation rewiring degron network	0.2778
p.P3804L	DO14160	HNSC	ICGC	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	3806:3819	Mutation rewiring degron network	0.2778
p.V547A	TCGA-D1-A167	UCEC	TCGA	ERAVLTCLI	DEG_APCC_DBOX_1	535:543	Mutation rewiring degron network	0.2222
p.V547A	DO40978	UCEC	ICGC	ERAVLTCLI	DEG_APCC_DBOX_1	535:543	Mutation rewiring degron network	0.2222
p.L2818P	TCGA-DD-AADM	LIHC	TCGA	PLTSS	DEG_SPOP_SBC_1	2817:2821	Mutation altering degron motif	0.6471
p.L2818P	DO52238	LIHC	ICGC	PLTSS	DEG_SPOP_SBC_1	2817:2821	Mutation altering degron motif	0.6471
p.I543M	TCGA-DK-AA6U	BLCA	TCGA	ERAVLTCLI	DEG_APCC_DBOX_1	535:543	Mutation altering degron motif	0.6507
p.I543M	DO219008	BLCA	ICGC	ERAVLTCLI	DEG_APCC_DBOX_1	535:543	Mutation altering degron motif	0.6507
p.P2519S	TCGA-DX-A6YS	SARC	TCGA	EVTGNPVPEI	DEG_COP1_1	2502:2511	Mutation rewiring degron network	0.1111
p.P2519S	TCGA-R6-A6L4	ESCA	TCGA	EVTGNPVPEI	DEG_COP1_1	2502:2511	Mutation rewiring degron network	0.1111
p.P2519S	DO220005	SARC	ICGC	EVTGNPVPEI	DEG_COP1_1	2502:2511	Mutation rewiring degron network	0.1111
p.V3817L	TCGA-E7-A7DV	BLCA	TCGA	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	3806:3819	Mutation altering degron motif	0.5654
p.V3817L	DO48583	BLCA	ICGC	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	3806:3819	Mutation altering degron motif	0.5654
p.V547M	TCGA-EE-A181	SKCM	TCGA	ERAVLTCLI	DEG_APCC_DBOX_1	535:543	Mutation rewiring degron network	0.2222
p.V547M	DO37444	SKCM	ICGC	ERAVLTCLI	DEG_APCC_DBOX_1	535:543	Mutation rewiring degron network	0.2222
p.G2517W	TCGA-EE-A3AA	SKCM	TCGA	EVTGNPVPEI	DEG_COP1_1	2502:2511	Mutation rewiring degron network	0.1667
p.G2517W	DO25104	LUAD	ICGC	EVTGNPVPEI	DEG_COP1_1	2502:2511	Mutation rewiring degron network	0.1667
p.G2517W	DO37571	SKCM	ICGC	EVTGNPVPEI	DEG_COP1_1	2502:2511	Mutation rewiring degron network	0.1667
p.S2821C	TCGA-EO-A22R	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	2817:2821	Mutation altering degron motif	0.7541
p.S2821C	DO42713	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	2817:2821	Mutation altering degron motif	0.7541
p.E2510A	TCGA-EO-A3B0	UCEC	TCGA	EVTGNPVPEI	DEG_COP1_1	2502:2511	Mutation altering degron motif	0.7701
p.E2510A	DO219773	UCEC	ICGC	EVTGNPVPEI	DEG_COP1_1	2502:2511	Mutation altering degron motif	0.7701
p.G2830W	TCGA-ER-A19G	SKCM	TCGA	PLTSS	DEG_SPOP_SBC_1	2817:2821	Mutation rewiring degron network	0.0833
p.G2830W	DO47284	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	2817:2821	Mutation rewiring degron network	0.0833
p.V4230A	TCGA-F7-7848	HNSC	TCGA	NLLGKYTAEP	CBL_PTK	4211:4220	Mutation rewiring degron network	0.0556
p.V4230A	DO14198	HNSC	ICGC	NLLGKYTAEP	CBL_PTK	4211:4220	Mutation rewiring degron network	0.0556
p.K2823R	TCGA-HU-A4H4	STAD	TCGA	PLTSS	DEG_SPOP_SBC_1	2817:2821	Mutation rewiring degron network	0.2778
p.K2823R	DO47721	STAD	ICGC	PLTSS	DEG_SPOP_SBC_1	2817:2821	Mutation rewiring degron network	0.2778
p.W2513L	TCGA-L9-A7SV	LUAD	TCGA	EVTGNPVPEI	DEG_COP1_1	2502:2511	Mutation rewiring degron network	0.2778
p.W2513L	DO49875	LUAD	ICGC	EVTGNPVPEI	DEG_COP1_1	2502:2511	Mutation rewiring degron network	0.2778
p.T3811A	DO6522	CLLE	ICGC	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	3806:3819	Mutation altering degron motif	0.6028
p.E4223K	DO222798	COCA	ICGC	NLLGKYTAEP	CBL_PTK	4211:4220	Mutation rewiring degron network	0.25
p.N4211T	DO50436	ESAD	ICGC	NLLGKYTAEP	CBL_PTK	4211:4220	Mutation altering degron motif	0.7055
p.K2492E	DO50396	ESAD	ICGC	EVTGNPVPEI	DEG_COP1_1	2502:2511	Mutation substituting flanking lysine	0.1667
p.V3800I	DO50349	ESAD	ICGC	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	3806:3819	Mutation rewiring degron network	0.1667
p.E4227K	DO48246	ESCA	ICGC	NLLGKYTAEP	CBL_PTK	4211:4220	Mutation rewiring degron network	0.1389
p.A537T	DO233944	GACA	ICGC	ERAVLTCLI	DEG_APCC_DBOX_1	535:543	Mutation altering degron motif	0.6028
p.Q2518K	DO233908	GACA	ICGC	EVTGNPVPEI	DEG_COP1_1	2502:2511	Mutation rewiring degron network	0.1389
p.A546E	DO228841	LICA	ICGC	ERAVLTCLI	DEG_APCC_DBOX_1	535:543	Mutation rewiring degron network	0.25
p.V4207F	DO229028	LICA	ICGC	NLLGKYTAEP	CBL_PTK	4211:4220	Mutation rewiring degron network	0.2222
p.V2503L	DO229037	LICA	ICGC	EVTGNPVPEI	DEG_COP1_1	2502:2511	Mutation altering degron motif	0.5654
p.G4214R	DO50893	LICA	ICGC	NLLGKYTAEP	CBL_PTK	4211:4220	Mutation altering degron motif	0.6457
p.P2509T	DO44726	LICA	ICGC	EVTGNPVPEI	DEG_COP1_1	2502:2511	Mutation altering degron motif	0.7031
p.E2493K	DO23414	LINC	ICGC	EVTGNPVPEI	DEG_COP1_1	2502:2511	Mutation rewiring degron network	0.0833
p.G2829A	DO23310	LINC	ICGC	PLTSS	DEG_SPOP_SBC_1	2817:2821	Mutation rewiring degron network	0.1111
p.P2519L	DO222875	MELA	ICGC	EVTGNPVPEI	DEG_COP1_1	2502:2511	Mutation rewiring degron network	0.1111
p.V538I	DO33288	PACA	ICGC	ERAVLTCLI	DEG_APCC_DBOX_1	535:543	Mutation altering degron motif	0.5965
p.P2817T	DO34128	PACA	ICGC	PLTSS	DEG_SPOP_SBC_1	2817:2821	Mutation altering degron motif	0.7031
p.T2504K	SIDM01265	Plasma Cell Myeloma	GDSC	EVTGNPVPEI	DEG_COP1_1	2502:2511	Mutation altering degron motif	0.7306
p.T2504K	SIDM01090	Colorectal Carcinoma	GDSC	EVTGNPVPEI	DEG_COP1_1	2502:2511	Mutation altering degron motif	0.7306
p.T2504K	SIDM00967	Ovarian Carcinoma	GDSC	EVTGNPVPEI	DEG_COP1_1	2502:2511	Mutation altering degron motif	0.7306
p.T2504K	SIDM00393	Gastric Carcinoma	GDSC	EVTGNPVPEI	DEG_COP1_1	2502:2511	Mutation altering degron motif	0.7306
p.T2504K	SIDM00633	Breast Carcinoma	GDSC	EVTGNPVPEI	DEG_COP1_1	2502:2511	Mutation altering degron motif	0.7306
p.T2504K	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	EVTGNPVPEI	DEG_COP1_1	2502:2511	Mutation altering degron motif	0.7306
p.T2504K	SIDM01409	Bladder Carcinoma	GDSC	EVTGNPVPEI	DEG_COP1_1	2502:2511	Mutation altering degron motif	0.7306
p.V529F	SIDM00113	Kidney Carcinoma	GDSC	ERAVLTCLI	DEG_APCC_DBOX_1	535:543	Mutation rewiring degron network	0.1667
p.V529F	TK10	kidney	COSMIC	ERAVLTCLI	DEG_APCC_DBOX_1	535:543	Mutation rewiring degron network	0.1667
p.P2817S	SIDM01175	Other Sarcomas	GDSC	PLTSS	DEG_SPOP_SBC_1	2817:2821	Mutation altering degron motif	0.6752
p.P2817S	ACH-002309	Sarcoma	CCLE	PLTSS	DEG_SPOP_SBC_1	2817:2821	Mutation altering degron motif	0.6752
p.P2817S	SW684	soft tissue	COSMIC	PLTSS	DEG_SPOP_SBC_1	2817:2821	Mutation altering degron motif	0.6752
p.Y4221H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	NLLGKYTAEP	CBL_PTK	4211:4220	Mutation rewiring degron network	0.3056
p.Y4221H	ACH-002256	Leukemia	CCLE	NLLGKYTAEP	CBL_PTK	4211:4220	Mutation rewiring degron network	0.3056
p.Y4221H	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	NLLGKYTAEP	CBL_PTK	4211:4220	Mutation rewiring degron network	0.3056
p.K2515T	SIDM00193	Colorectal Carcinoma	GDSC	EVTGNPVPEI	DEG_COP1_1	2502:2511	Mutation substituting flanking lysine	0.3333
p.K2515T	ACH-000991	Colon/Colorectal Cancer	CCLE	EVTGNPVPEI	DEG_COP1_1	2502:2511	Mutation substituting flanking lysine	0.3333
p.K2515T	SNU-81	large intestine	COSMIC	EVTGNPVPEI	DEG_COP1_1	2502:2511	Mutation substituting flanking lysine	0.3333
p.V525E	SIDM00296	Small Cell Lung Carcinoma	GDSC	ERAVLTCLI	DEG_APCC_DBOX_1	535:543	Mutation rewiring degron network	0.0556
p.V525E	ACH-002051	Lung Cancer	CCLE	ERAVLTCLI	DEG_APCC_DBOX_1	535:543	Mutation rewiring degron network	0.0556
p.V525E	LU-134-A	lung	COSMIC	ERAVLTCLI	DEG_APCC_DBOX_1	535:543	Mutation rewiring degron network	0.0556
p.D4205G	SIDM00118	Colorectal Carcinoma	GDSC	NLLGKYTAEP	CBL_PTK	4211:4220	Mutation rewiring degron network	0.1667
p.D4205G	ACH-001081	Colon/Colorectal Cancer	CCLE	NLLGKYTAEP	CBL_PTK	4211:4220	Mutation rewiring degron network	0.1667
p.D4205G	HCC2998	large intestine	COSMIC	NLLGKYTAEP	CBL_PTK	4211:4220	Mutation rewiring degron network	0.1667
p.I3806V	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	3806:3819	Mutation altering degron motif	0.7076
p.I3806V	ACH-000912	Lung Cancer	CCLE	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	3806:3819	Mutation altering degron motif	0.7076
p.V3815I	SIDM00169	Head and Neck Carcinoma	GDSC	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	3806:3819	Mutation altering degron motif	0.5965
p.V3815I	ACH-000692	Head and Neck Cancer	CCLE	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	3806:3819	Mutation altering degron motif	0.5965
p.G534V	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	ERAVLTCLI	DEG_APCC_DBOX_1	535:543	Mutation rewiring degron network	0.3056
p.G534V	ACH-000891	Lung Cancer	CCLE	ERAVLTCLI	DEG_APCC_DBOX_1	535:543	Mutation rewiring degron network	0.3056
p.P3803H	ACH-001610	Brain Cancer	CCLE	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	3806:3819	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HMCN1

UniProt ID: Q96RW7

Entrez ID: 83872

Protein name: Hemicentin-1 (Fibulin-6) (FIBL-6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HMCN1 in