DegronMD

Uniprot ID: Q96RW7

Source protein: Hemicentin-1

Source gene: HMCN1

Class: DEG_COP1_1

Location: 2502:2511

E3 ligase: COP1

DEGRON score: 0.6592

ASA_SCORE: 61.53

COIL: 0.59

CONS_SCORE: 0.4936

DSS_SCORE: 0.4554

HELIX: 0.004

FCONS_SCORE: 1.0279

RIG_SCORE: 0.7517

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G2517V	TCGA-39-5016	LUSC	TCGA	EVTGNPVPEI	DEG_COP1_1	0.1667
p.G2517V	DO26701	LUSC	ICGC	EVTGNPVPEI	DEG_COP1_1	0.1667
p.T2498M	TCGA-AP-A0LM	UCEC	TCGA	EVTGNPVPEI	DEG_COP1_1	0.2222
p.T2498M	DO43306	UCEC	ICGC	EVTGNPVPEI	DEG_COP1_1	0.2222
p.P2519S	TCGA-DX-A6YS	SARC	TCGA	EVTGNPVPEI	DEG_COP1_1	0.1111
p.P2519S	TCGA-R6-A6L4	ESCA	TCGA	EVTGNPVPEI	DEG_COP1_1	0.1111
p.P2519S	DO220005	SARC	ICGC	EVTGNPVPEI	DEG_COP1_1	0.1111
p.G2517W	TCGA-EE-A3AA	SKCM	TCGA	EVTGNPVPEI	DEG_COP1_1	0.1667
p.G2517W	DO25104	LUAD	ICGC	EVTGNPVPEI	DEG_COP1_1	0.1667
p.G2517W	DO37571	SKCM	ICGC	EVTGNPVPEI	DEG_COP1_1	0.1667
p.E2510A	TCGA-EO-A3B0	UCEC	TCGA	EVTGNPVPEI	DEG_COP1_1	0.7701
p.E2510A	DO219773	UCEC	ICGC	EVTGNPVPEI	DEG_COP1_1	0.7701
p.W2513L	TCGA-L9-A7SV	LUAD	TCGA	EVTGNPVPEI	DEG_COP1_1	0.2778
p.W2513L	DO49875	LUAD	ICGC	EVTGNPVPEI	DEG_COP1_1	0.2778
p.K2492E	DO50396	ESAD	ICGC	EVTGNPVPEI	DEG_COP1_1	0.1667
p.Q2518K	DO233908	GACA	ICGC	EVTGNPVPEI	DEG_COP1_1	0.1389
p.V2503L	DO229037	LICA	ICGC	EVTGNPVPEI	DEG_COP1_1	0.5654
p.P2509T	DO44726	LICA	ICGC	EVTGNPVPEI	DEG_COP1_1	0.7031
p.E2493K	DO23414	LINC	ICGC	EVTGNPVPEI	DEG_COP1_1	0.0833
p.P2519L	DO222875	MELA	ICGC	EVTGNPVPEI	DEG_COP1_1	0.1111
p.T2504K	SIDM01265	Plasma Cell Myeloma	GDSC	EVTGNPVPEI	DEG_COP1_1	0.7306
p.T2504K	SIDM01090	Colorectal Carcinoma	GDSC	EVTGNPVPEI	DEG_COP1_1	0.7306
p.T2504K	SIDM00967	Ovarian Carcinoma	GDSC	EVTGNPVPEI	DEG_COP1_1	0.7306
p.T2504K	SIDM00393	Gastric Carcinoma	GDSC	EVTGNPVPEI	DEG_COP1_1	0.7306
p.T2504K	SIDM00633	Breast Carcinoma	GDSC	EVTGNPVPEI	DEG_COP1_1	0.7306
p.T2504K	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	EVTGNPVPEI	DEG_COP1_1	0.7306
p.T2504K	SIDM01409	Bladder Carcinoma	GDSC	EVTGNPVPEI	DEG_COP1_1	0.7306
p.K2515T	SIDM00193	Colorectal Carcinoma	GDSC	EVTGNPVPEI	DEG_COP1_1	0.3333
p.K2515T	ACH-000991	Colon/Colorectal Cancer	CCLE	EVTGNPVPEI	DEG_COP1_1	0.3333
p.K2515T	SNU-81	large_intestine	COSMIC	EVTGNPVPEI	DEG_COP1_1	0.3333

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EVTGNPVPEI

Degron related mutations and impact score

Drug responses associated with HMCN1 mutations

All proteins holding degron of EVTGNPVPEI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96RW7	Hemicentin-1	DEG_COP1_1	2502:2511	EVTGNPVPEI	COP1	0.6592	More...