DegronMD

Uniprot ID: Q96RW7

Source protein: Hemicentin-1

Source gene: HMCN1

Class: CBL_PTK

Location: 4211:4220

E3 ligase: CBL

DEGRON score: 0.5785

ASA_SCORE: 76.05

COIL: 0.5065

CONS_SCORE: 0.3994

DSS_SCORE: 0.0482

HELIX: 0.029

FCONS_SCORE: 0.863

RIG_SCORE: 0.871

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V4230A	TCGA-F7-7848	HNSC	TCGA	NLLGKYTAEP	CBL_PTK	0.0556
p.V4230A	DO14198	HNSC	ICGC	NLLGKYTAEP	CBL_PTK	0.0556
p.E4223K	DO222798	COCA	ICGC	NLLGKYTAEP	CBL_PTK	0.25
p.N4211T	DO50436	ESAD	ICGC	NLLGKYTAEP	CBL_PTK	0.7055
p.E4227K	DO48246	ESCA	ICGC	NLLGKYTAEP	CBL_PTK	0.1389
p.V4207F	DO229028	LICA	ICGC	NLLGKYTAEP	CBL_PTK	0.2222
p.G4214R	DO50893	LICA	ICGC	NLLGKYTAEP	CBL_PTK	0.6457
p.Y4221H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	NLLGKYTAEP	CBL_PTK	0.3056
p.Y4221H	ACH-002256	Leukemia	CCLE	NLLGKYTAEP	CBL_PTK	0.3056
p.Y4221H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	NLLGKYTAEP	CBL_PTK	0.3056
p.D4205G	SIDM00118	Colorectal Carcinoma	GDSC	NLLGKYTAEP	CBL_PTK	0.1667
p.D4205G	ACH-001081	Colon/Colorectal Cancer	CCLE	NLLGKYTAEP	CBL_PTK	0.1667
p.D4205G	HCC2998	large_intestine	COSMIC	NLLGKYTAEP	CBL_PTK	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96RW7	Hemicentin-1	CBL_PTK	4211:4220	NLLGKYTAEP	CBL	0.5785	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons