DegronMD

Uniprot ID: Q96RW7

Source protein: Hemicentin-1

Source gene: HMCN1

Class: DEG_APCC_DBOX_1

Location: 535:543

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5326

ASA_SCORE: 46.7667

COIL: 0.2292

CONS_SCORE: 0.3759

DSS_SCORE: 0.1014

HELIX: 0.0013

FCONS_SCORE: 0.9256

RIG_SCORE: 0.941

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A546V	TCGA-2W-A8YY	CESC	TCGA	ERAVLTCLI	DEG_APCC_DBOX_1	0.25
p.A546V	DO223732	CESC	ICGC	ERAVLTCLI	DEG_APCC_DBOX_1	0.25
p.V547A	TCGA-D1-A167	UCEC	TCGA	ERAVLTCLI	DEG_APCC_DBOX_1	0.2222
p.V547A	DO40978	UCEC	ICGC	ERAVLTCLI	DEG_APCC_DBOX_1	0.2222
p.I543M	TCGA-DK-AA6U	BLCA	TCGA	ERAVLTCLI	DEG_APCC_DBOX_1	0.6507
p.I543M	DO219008	BLCA	ICGC	ERAVLTCLI	DEG_APCC_DBOX_1	0.6507
p.V547M	TCGA-EE-A181	SKCM	TCGA	ERAVLTCLI	DEG_APCC_DBOX_1	0.2222
p.V547M	DO37444	SKCM	ICGC	ERAVLTCLI	DEG_APCC_DBOX_1	0.2222
p.A537T	DO233944	GACA	ICGC	ERAVLTCLI	DEG_APCC_DBOX_1	0.6028
p.A546E	DO228841	LICA	ICGC	ERAVLTCLI	DEG_APCC_DBOX_1	0.25
p.V538I	DO33288	PACA	ICGC	ERAVLTCLI	DEG_APCC_DBOX_1	0.5965
p.V529F	SIDM00113	Kidney Carcinoma	GDSC	ERAVLTCLI	DEG_APCC_DBOX_1	0.1667
p.V529F	TK10	kidney	COSMIC	ERAVLTCLI	DEG_APCC_DBOX_1	0.1667
p.V525E	SIDM00296	Small Cell Lung Carcinoma	GDSC	ERAVLTCLI	DEG_APCC_DBOX_1	0.0556
p.V525E	ACH-002051	Lung Cancer	CCLE	ERAVLTCLI	DEG_APCC_DBOX_1	0.0556
p.V525E	LU-134-A	lung	COSMIC	ERAVLTCLI	DEG_APCC_DBOX_1	0.0556
p.G534V	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	ERAVLTCLI	DEG_APCC_DBOX_1	0.3056
p.G534V	ACH-000891	Lung Cancer	CCLE	ERAVLTCLI	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96RW7	Hemicentin-1	DEG_APCC_DBOX_1	535:543	ERAVLTCLI	APC,CDC20,FZR1	0.5326	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons