DegronMD

Uniprot ID: Q96RW7

Source protein: Hemicentin-1

Source gene: HMCN1

Class: DEG_ODPH_VHL_1

Location: 3806:3819

E3 ligase: VHL

DEGRON score: 0.8625

ASA_SCORE: 65.9857

COIL: 0.6029

CONS_SCORE: 0.3225

DSS_SCORE: 0.339

HELIX: 0.0069

FCONS_SCORE: 0.8359

RIG_SCORE: 0.7665

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G3809S	TCGA-55-8204	LUAD	TCGA	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	0.5882
p.G3809S	DO45322	LUAD	ICGC	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	0.5882
p.G3829V	TCGA-64-5781	LUAD	TCGA	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	0.0556
p.G3829V	DO23740	LUAD	ICGC	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	0.0556
p.Q3799H	TCGA-69-7979	LUAD	TCGA	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	0.1389
p.Q3799H	DO23874	LUAD	ICGC	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	0.1389
p.P3804L	TCGA-CV-7568	HNSC	TCGA	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	0.2778
p.P3804L	DO14160	HNSC	ICGC	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	0.2778
p.V3817L	TCGA-E7-A7DV	BLCA	TCGA	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	0.5654
p.V3817L	DO48583	BLCA	ICGC	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	0.5654
p.T3811A	DO6522	CLLE	ICGC	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	0.6028
p.V3800I	DO50349	ESAD	ICGC	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	0.1667
p.I3806V	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	0.7076
p.I3806V	ACH-000912	Lung Cancer	CCLE	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	0.7076
p.V3815I	SIDM00169	Head and Neck Carcinoma	GDSC	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	0.5965
p.V3815I	ACH-000692	Head and Neck Cancer	CCLE	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	0.5965
p.P3803H	ACH-001610	Brain Cancer	CCLE	IAPGPTNMTVIVNV	DEG_ODPH_VHL_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96RW7	Hemicentin-1	DEG_ODPH_VHL_1	3806:3819	IAPGPTNMTVIVNV	VHL	0.8625	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons