DegronMD - Q5HYW2(NHSL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G774C	NCI-H2347	lung	COSMIC	PLTSS	DEG_SPOP_SBC_1	774:778	Mutation altering degron motif	0.76
p.A308S	DO232012	LICA	ICGC	AHSTT	DEG_SPOP_SBC_1	308:312	Mutation altering degron motif	0.7588
p.P722A	TCGA-A5-A0GP	UCEC	TCGA	PTPTVS	DEG_SCF_FBW7_1	722:727	Mutation altering degron motif	0.7503
p.P399S	ACH-000810	Skin Cancer	CCLE	MTPSAT	DEG_SCF_FBW7_1	400:405	Mutation blocking phosphorylation signal	0.75
p.P399S	SK-MEL-30	skin	COSMIC	MTPSAT	DEG_SCF_FBW7_1	400:405	Mutation blocking phosphorylation signal	0.75
p.S342L	SIDM00922	Non-Small Cell Lung Carcinoma	GDSC	VLRTPSSE	DEG_SCF_FBW7_2	344:351	Mutation blocking phosphorylation signal	0.7222
p.T723A	TCGA-B5-A0JY	UCEC	TCGA	PTPTVS	DEG_SCF_FBW7_1	722:727	Mutation altering degron motif	0.7139
p.T723A	DO43041	UCEC	ICGC	PTPTVS	DEG_SCF_FBW7_1	722:727	Mutation altering degron motif	0.7139
p.L777M	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	PLTSS	DEG_SPOP_SBC_1	774:778	Mutation altering degron motif	0.711
p.Q402P	DO40884	UCEC	ICGC	MTPSAT	DEG_SCF_FBW7_1	400:405	Mutation altering degron motif	0.7035
p.P737T	TCGA-CR-7388	HNSC	TCGA	PPSSS	DEG_SPOP_SBC_1	737:741	Mutation altering degron motif	0.7031
p.P737T	DO14284	HNSC	ICGC	PPSSS	DEG_SPOP_SBC_1	737:741	Mutation altering degron motif	0.7031
p.K400E	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	MTPSAT	DEG_SCF_FBW7_1	400:405	Mutation altering degron motif	0.7022
p.G774S	WM-115	skin	COSMIC	PLTSS	DEG_SPOP_SBC_1	774:778	Mutation altering degron motif	0.6993
p.F403L	DO9002	COAD	ICGC	MTPSAT	DEG_SCF_FBW7_1	400:405	Mutation altering degron motif	0.6981
p.F403L	DO43306	UCEC	ICGC	MTPSAT	DEG_SCF_FBW7_1	400:405	Mutation altering degron motif	0.6981
p.D726N	DO233725	GACA	ICGC	PTPTVS	DEG_SCF_FBW7_1	722:727	Mutation altering degron motif	0.6932
p.D349N	DO42793	UCEC	ICGC	VLRTPSSE	DEG_SCF_FBW7_2	344:351	Mutation altering degron motif	0.6932
p.P774S	TCGA-AP-A051	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	774:778	Mutation altering degron motif	0.6752
p.P1032L	TCGA-DM-A1D8	COAD	TCGA	PRLPLSPII	DEG_APCC_DBOX_1	1029:1037	Mutation altering degron motif	0.6471

Showing 1 to 20 of 105 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

NHSL2

UniProt ID: Q5HYW2

Entrez ID: 340527

Protein name: NHS-like protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NHSL2 in