DegronMD - Q5HYW2(NHSL2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S937N	TCGA-2W-A8YY	CESC	TCGA	LVFTPFAS	DEG_SCF_FBW7_1	947:954	Mutation rewiring degron network	0.0556
p.S937N	DO223732	CESC	ICGC	LVFTPFAS	DEG_SCF_FBW7_1	947:954	Mutation rewiring degron network	0.0556
p.P779S	TCGA-33-4583	LUSC	TCGA	PLTSS	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.3056
p.V742F	TCGA-49-AARO	LUAD	TCGA	PPSSS	DEG_SPOP_SBC_1	737:741	Mutation rewiring degron network	0.3056
p.P722A	TCGA-A5-A0GP	UCEC	TCGA	PTPTVS	DEG_SCF_FBW7_1	722:727	Mutation altering degron motif	0.7503
p.P774S	TCGA-AP-A051	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	774:778	Mutation altering degron motif	0.6752
p.R768Q	TCGA-AP-A0LM	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.1667
p.R768Q	DO43306	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.1667
p.Q964H	TCGA-AP-A0LM	UCEC	TCGA	LVFTPFAS	DEG_SCF_FBW7_1	947:954	Mutation rewiring degron network	0.0556
p.T723A	TCGA-B5-A0JY	UCEC	TCGA	PTPTVS	DEG_SCF_FBW7_1	722:727	Mutation altering degron motif	0.7139
p.T723A	DO43041	UCEC	ICGC	PTPTVS	DEG_SCF_FBW7_1	722:727	Mutation altering degron motif	0.7139
p.I1036V	TCGA-B8-4620	KIRC	TCGA	PRLPLSPII	DEG_APCC_DBOX_1	1029:1037	Mutation altering degron motif	0.5965
p.I1036V	DO19893	KIRC	ICGC	PRLPLSPII	DEG_APCC_DBOX_1	1029:1037	Mutation altering degron motif	0.5965
p.G785V	TCGA-BH-A18G	BRCA	TCGA	PLTSS	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.1389
p.F764C	TCGA-BS-A0UF	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.0556
p.F764C	TCGA-CA-6717	COAD	TCGA	PLTSS	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.0556
p.F764C	DO8264	COAD	ICGC	PLTSS	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.0556
p.F764C	DO41488	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.0556
p.V742I	TCGA-CD-A4MG	STAD	TCGA	PPSSS	DEG_SPOP_SBC_1	737:741	Mutation rewiring degron network	0.3056
p.Q407H	TCGA-CN-6010	HNSC	TCGA	MTPSAT	DEG_SCF_FBW7_1	400:405	Mutation rewiring degron network	0.2778
p.Q407H	DO14766	HNSC	ICGC	MTPSAT	DEG_SCF_FBW7_1	400:405	Mutation rewiring degron network	0.2778
p.P737T	TCGA-CR-7388	HNSC	TCGA	PPSSS	DEG_SPOP_SBC_1	737:741	Mutation altering degron motif	0.7031
p.P737T	DO14284	HNSC	ICGC	PPSSS	DEG_SPOP_SBC_1	737:741	Mutation altering degron motif	0.7031
p.A358V	TCGA-CZ-5469	KIRC	TCGA	VLRTPSSE	DEG_SCF_FBW7_2	344:351	Mutation rewiring degron network	0.1389
p.A358V	DO16580	KIRC	ICGC	VLRTPSSE	DEG_SCF_FBW7_2	344:351	Mutation rewiring degron network	0.1389
p.S770L	TCGA-D3-A5GO	SKCM	TCGA	PLTSS	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.2222
p.P322T	TCGA-DD-AADB	LIHC	TCGA	AHSTT	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.0556
p.P322T	DO52229	LIHC	ICGC	AHSTT	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.0556
p.P1032L	TCGA-DM-A1D8	COAD	TCGA	PRLPLSPII	DEG_APCC_DBOX_1	1029:1037	Mutation altering degron motif	0.6471
p.P1032L	DO8914	COAD	ICGC	PRLPLSPII	DEG_APCC_DBOX_1	1029:1037	Mutation altering degron motif	0.6471
p.G939V	TCGA-E8-A2EA	THCA	TCGA	LVFTPFAS	DEG_SCF_FBW7_1	947:954	Mutation rewiring degron network	0.1111
p.D782N	TCGA-EE-A29L	SKCM	TCGA	PLTSS	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.2222
p.D782N	DO222599	MELA	ICGC	PLTSS	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.2222
p.D782N	DO37835	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.2222
p.S339G	TCGA-FA-A7Q1	DLBC	TCGA	VLRTPSSE	DEG_SCF_FBW7_2	344:351	Mutation rewiring degron network	0.1944
p.S729F	TCGA-FI-A2D5	UCEC	TCGA	PTPTVS	DEG_SCF_FBW7_1	722:727	Mutation rewiring degron network	0.2778
p.S729F	TCGA-FI-A2D5	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	737:741	Mutation rewiring degron network	0.1111
p.I1036L	TCGA-FK-A3SH	THCA	TCGA	PRLPLSPII	DEG_APCC_DBOX_1	1029:1037	Mutation altering degron motif	0.6063
p.E940K	TCGA-FW-A3R5	SKCM	TCGA	LVFTPFAS	DEG_SCF_FBW7_1	947:954	Mutation rewiring degron network	0.1389
p.M1022I	TCGA-GN-A26C	SKCM	TCGA	PRLPLSPII	DEG_APCC_DBOX_1	1029:1037	Mutation rewiring degron network	0.1389
p.M1022I	DO37782	SKCM	ICGC	PRLPLSPII	DEG_APCC_DBOX_1	1029:1037	Mutation rewiring degron network	0.1389
p.S528G	TCGA-NH-A5IV	COAD	TCGA	ASTSS	DEG_SPOP_SBC_1	527:531	Mutation altering degron motif	0.5882
p.F403L	DO9002	COAD	ICGC	MTPSAT	DEG_SCF_FBW7_1	400:405	Mutation altering degron motif	0.6981
p.F403L	DO43306	UCEC	ICGC	MTPSAT	DEG_SCF_FBW7_1	400:405	Mutation altering degron motif	0.6981
p.V773I	DO7776	COAD	ICGC	PLTSS	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.3056
p.T785I	DO7843	COAD	ICGC	PLTSS	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.1389
p.L409I	DO8264	COAD	ICGC	MTPSAT	DEG_SCF_FBW7_1	400:405	Mutation rewiring degron network	0.2222
p.D541G	DO223006	ESCA	ICGC	ASTSS	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.0556
p.A1047T	DO233060	GACA	ICGC	PRLPLSPII	DEG_APCC_DBOX_1	1029:1037	Mutation rewiring degron network	0.0556
p.R336Q	DO233266	GACA	ICGC	VLRTPSSE	DEG_SCF_FBW7_2	344:351	Mutation rewiring degron network	0.1111
p.D726N	DO233725	GACA	ICGC	PTPTVS	DEG_SCF_FBW7_1	722:727	Mutation altering degron motif	0.6932
p.A308S	DO232012	LICA	ICGC	AHSTT	DEG_SPOP_SBC_1	308:312	Mutation altering degron motif	0.7588
p.A391S	DO229037	LICA	ICGC	MTPSAT	DEG_SCF_FBW7_1	400:405	Mutation rewiring degron network	0.0833
p.V321D	DO231646	LINC	ICGC	AHSTT	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.0833
p.R745C	DO231673	LINC	ICGC	PPSSS	DEG_SPOP_SBC_1	737:741	Mutation rewiring degron network	0.2222
p.V779L	DO26052	LUAD	ICGC	PLTSS	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.3056
p.G358E	DO222653	MELA	ICGC	VLRTPSSE	DEG_SCF_FBW7_2	344:351	Mutation rewiring degron network	0.1389
p.T719M	DO49159	PACA	ICGC	PTPTVS	DEG_SCF_FBW7_1	722:727	Mutation rewiring degron network	0.25
p.V726F	DO51148	PRAD	ICGC	PTPTVS	DEG_SCF_FBW7_1	722:727	Mutation altering degron motif	0.5957
p.S343I	DO36853	READ	ICGC	VLRTPSSE	DEG_SCF_FBW7_2	344:351	Mutation rewiring degron network	0.3056
p.W412L	DO47278	SKCM	ICGC	MTPSAT	DEG_SCF_FBW7_1	400:405	Mutation rewiring degron network	0.1389
p.P787H	DO47442	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.0833
p.S539L	DO47419	SKCM	ICGC	ASTSS	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.1111
p.A523D	DO229208	THCA	ICGC	ASTSS	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.2222
p.Q402P	DO40884	UCEC	ICGC	MTPSAT	DEG_SCF_FBW7_1	400:405	Mutation altering degron motif	0.7035
p.D397Y	DO50076	UCEC	ICGC	MTPSAT	DEG_SCF_FBW7_1	400:405	Mutation rewiring degron network	0.25
p.Q733H	DO43306	UCEC	ICGC	PTPTVS	DEG_SCF_FBW7_1	722:727	Mutation rewiring degron network	0.1667
p.Q733H	DO43306	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	737:741	Mutation rewiring degron network	0.2222
p.P337H	DO42985	UCEC	ICGC	VLRTPSSE	DEG_SCF_FBW7_2	344:351	Mutation rewiring degron network	0.1389
p.P337S	DO41871	UCEC	ICGC	VLRTPSSE	DEG_SCF_FBW7_2	344:351	Mutation rewiring degron network	0.1389
p.D349N	DO42793	UCEC	ICGC	VLRTPSSE	DEG_SCF_FBW7_2	344:351	Mutation altering degron motif	0.6932
p.R359W	SIDM00061	Ovarian Carcinoma	GDSC	VLRTPSSE	DEG_SCF_FBW7_2	344:351	Mutation rewiring degron network	0.1111
p.P765S	SIDM00392	Melanoma	GDSC	PLTSS	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.0833
p.P765S	SK-MEL-30	skin	COSMIC	PLTSS	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.0833
p.E750Q	SIDM00995	Other Solid Cancers	GDSC	PPSSS	DEG_SPOP_SBC_1	737:741	Mutation rewiring degron network	0.0833
p.E750Q	A431	skin	COSMIC	PPSSS	DEG_SPOP_SBC_1	737:741	Mutation rewiring degron network	0.0833
p.S342L	SIDM00922	Non-Small Cell Lung Carcinoma	GDSC	VLRTPSSE	DEG_SCF_FBW7_2	344:351	Mutation blocking phosphorylation signal	0.7222
p.R743Q	SIDM00519	Mesothelioma	GDSC	PPSSS	DEG_SPOP_SBC_1	737:741	Mutation rewiring degron network	0.2778
p.K766E	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	PLTSS	DEG_SPOP_SBC_1	774:778	Mutation substituting flanking lysine	0.2222
p.K766E	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	PLTSS	DEG_SPOP_SBC_1	774:778	Mutation substituting flanking lysine	0.2222
p.P399S	ACH-000810	Skin Cancer	CCLE	MTPSAT	DEG_SCF_FBW7_1	400:405	Mutation blocking phosphorylation signal	0.75
p.P399S	SK-MEL-30	skin	COSMIC	MTPSAT	DEG_SCF_FBW7_1	400:405	Mutation blocking phosphorylation signal	0.75
p.P540S	ACH-000915	Skin Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.0833
p.P540S	IPC-298	skin	COSMIC	ASTSS	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.0833
p.A318T	ACH-000999	Colon/Colorectal Cancer	CCLE	AHSTT	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.1667
p.A318T	SNU-1040	large intestine	COSMIC	AHSTT	DEG_SPOP_SBC_1	308:312	Mutation rewiring degron network	0.1667
p.K400E	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	MTPSAT	DEG_SCF_FBW7_1	400:405	Mutation altering degron motif	0.7022
p.P788T	NCI-H650	lung	COSMIC	PLTSS	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.0556
p.L960M	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	LVFTPFAS	DEG_SCF_FBW7_1	947:954	Mutation rewiring degron network	0.1667
p.E393K	CP67-MEL	skin	COSMIC	MTPSAT	DEG_SCF_FBW7_1	400:405	Mutation substituting flanking lysine	0.25
p.L335Q	HT55	large intestine	COSMIC	VLRTPSSE	DEG_SCF_FBW7_2	344:351	Mutation rewiring degron network	0.0833
p.G957C	NCI-H2347	lung	COSMIC	LVFTPFAS	DEG_SCF_FBW7_1	947:954	Mutation rewiring degron network	0.25
p.V779G	TGBC1TKB	biliary tract	COSMIC	PLTSS	DEG_SPOP_SBC_1	774:778	Mutation rewiring degron network	0.3056
p.L777M	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	PLTSS	DEG_SPOP_SBC_1	774:778	Mutation altering degron motif	0.711
p.V338L	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	VLRTPSSE	DEG_SCF_FBW7_2	344:351	Mutation rewiring degron network	0.1667
p.M730L	TE-5	oesophagus	COSMIC	PTPTVS	DEG_SCF_FBW7_1	722:727	Mutation rewiring degron network	0.25
p.M730L	TE-5	oesophagus	COSMIC	PPSSS	DEG_SPOP_SBC_1	737:741	Mutation rewiring degron network	0.1389
p.A409T	SNU-1040	large intestine	COSMIC	MTPSAT	DEG_SCF_FBW7_1	400:405	Mutation rewiring degron network	0.2222
p.G774C	NCI-H2347	lung	COSMIC	PLTSS	DEG_SPOP_SBC_1	774:778	Mutation altering degron motif	0.76
p.S334F	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	VLRTPSSE	DEG_SCF_FBW7_2	344:351	Mutation rewiring degron network	0.0556
p.Q719H	NCI-H187	lung	COSMIC	PTPTVS	DEG_SCF_FBW7_1	722:727	Mutation rewiring degron network	0.25
p.P746S	RKO	large intestine	COSMIC	PPSSS	DEG_SPOP_SBC_1	737:741	Mutation rewiring degron network	0.1944
p.G774S	WM-115	skin	COSMIC	PLTSS	DEG_SPOP_SBC_1	774:778	Mutation altering degron motif	0.6993
p.G957S	WM-115	skin	COSMIC	LVFTPFAS	DEG_SCF_FBW7_1	947:954	Mutation rewiring degron network	0.25
p.Q536H	NCI-H187	lung	COSMIC	ASTSS	DEG_SPOP_SBC_1	527:531	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NHSL2

UniProt ID: Q5HYW2

Entrez ID: 340527

Protein name: NHS-like protein 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NHSL2 in