DegronMD

Uniprot ID: Q5HYW2

Source protein: NHS-like protein 2

Source gene: NHSL2

Class: DEG_APCC_DBOX_1

Location: 1029:1037

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9687

ASA_SCORE: 94.4889

COIL: 0.9396

CONS_SCORE: 0

DSS_SCORE: 0.3795

HELIX: 0.0228

FCONS_SCORE: 0

RIG_SCORE: 0.7759

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1036V	TCGA-B8-4620	KIRC	TCGA	PRLPLSPII	DEG_APCC_DBOX_1	0.5965
p.I1036V	DO19893	KIRC	ICGC	PRLPLSPII	DEG_APCC_DBOX_1	0.5965
p.P1032L	TCGA-DM-A1D8	COAD	TCGA	PRLPLSPII	DEG_APCC_DBOX_1	0.6471
p.P1032L	DO8914	COAD	ICGC	PRLPLSPII	DEG_APCC_DBOX_1	0.6471
p.I1036L	TCGA-FK-A3SH	THCA	TCGA	PRLPLSPII	DEG_APCC_DBOX_1	0.6063
p.M1022I	TCGA-GN-A26C	SKCM	TCGA	PRLPLSPII	DEG_APCC_DBOX_1	0.1389
p.M1022I	DO37782	SKCM	ICGC	PRLPLSPII	DEG_APCC_DBOX_1	0.1389
p.A1047T	DO233060	GACA	ICGC	PRLPLSPII	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5HYW2	NHS-like protein 2	DEG_APCC_DBOX_1	1029:1037	PRLPLSPII	APC,CDC20,FZR1	0.9687	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons