DegronMD

Uniprot ID: Q5HYW2

Source protein: NHS-like protein 2

Source gene: NHSL2

Class: DEG_SCF_FBW7_1

Location: 947:954

E3 ligase: FBXW7

DEGRON score: 0.937

ASA_SCORE: 85.025

COIL: 0.9184

CONS_SCORE: 0

DSS_SCORE: 0.4957

HELIX: 0.0393

FCONS_SCORE: 0

RIG_SCORE: 0.7119

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S937N	TCGA-2W-A8YY	CESC	TCGA	LVFTPFAS	DEG_SCF_FBW7_1	0.0556
p.S937N	DO223732	CESC	ICGC	LVFTPFAS	DEG_SCF_FBW7_1	0.0556
p.Q964H	TCGA-AP-A0LM	UCEC	TCGA	LVFTPFAS	DEG_SCF_FBW7_1	0.0556
p.G939V	TCGA-E8-A2EA	THCA	TCGA	LVFTPFAS	DEG_SCF_FBW7_1	0.1111
p.E940K	TCGA-FW-A3R5	SKCM	TCGA	LVFTPFAS	DEG_SCF_FBW7_1	0.1389
p.L960M	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	LVFTPFAS	DEG_SCF_FBW7_1	0.1667
p.G957C	NCI-H2347	lung	COSMIC	LVFTPFAS	DEG_SCF_FBW7_1	0.25
p.G957S	WM-115	skin	COSMIC	LVFTPFAS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5HYW2	NHS-like protein 2	DEG_SCF_FBW7_1	947:954	LVFTPFAS	FBXW7	0.937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons