DegronMD

Uniprot ID: Q5HYW2

Source protein: NHS-like protein 2

Source gene: NHSL2

Class: DEG_SCF_FBW7_2

Location: 344:351

E3 ligase: FBXW7

DEGRON score: 0.997

ASA_SCORE: 91.875

COIL: 0.926

CONS_SCORE: 0.9839

DSS_SCORE: 0.7579

HELIX: 0.0276

FCONS_SCORE: 1.304

RIG_SCORE: 0.5875

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A358V	TCGA-CZ-5469	KIRC	TCGA	VLRTPSSE	DEG_SCF_FBW7_2	0.1389
p.A358V	DO16580	KIRC	ICGC	VLRTPSSE	DEG_SCF_FBW7_2	0.1389
p.S339G	TCGA-FA-A7Q1	DLBC	TCGA	VLRTPSSE	DEG_SCF_FBW7_2	0.1944
p.R336Q	DO233266	GACA	ICGC	VLRTPSSE	DEG_SCF_FBW7_2	0.1111
p.G358E	DO222653	MELA	ICGC	VLRTPSSE	DEG_SCF_FBW7_2	0.1389
p.S343I	DO36853	READ	ICGC	VLRTPSSE	DEG_SCF_FBW7_2	0.3056
p.P337H	DO42985	UCEC	ICGC	VLRTPSSE	DEG_SCF_FBW7_2	0.1389
p.P337S	DO41871	UCEC	ICGC	VLRTPSSE	DEG_SCF_FBW7_2	0.1389
p.D349N	DO42793	UCEC	ICGC	VLRTPSSE	DEG_SCF_FBW7_2	0.6932
p.R359W	SIDM00061	Ovarian Carcinoma	GDSC	VLRTPSSE	DEG_SCF_FBW7_2	0.1111
p.S342L	SIDM00922	Non-Small Cell Lung Carcinoma	GDSC	VLRTPSSE	DEG_SCF_FBW7_2	0.7222
p.L335Q	HT55	large_intestine	COSMIC	VLRTPSSE	DEG_SCF_FBW7_2	0.0833
p.V338L	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	VLRTPSSE	DEG_SCF_FBW7_2	0.1667
p.S334F	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	VLRTPSSE	DEG_SCF_FBW7_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5HYW2	NHS-like protein 2	DEG_SCF_FBW7_2	344:351	VLRTPSSE	FBXW7	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons