DegronMD

Uniprot ID: Q5HYW2

Source protein: NHS-like protein 2

Source gene: NHSL2

Class: DEG_SCF_FBW7_1

Location: 722:727

E3 ligase: FBXW7

DEGRON score: 0.9927

ASA_SCORE: 76.6667

COIL: 0.9535

CONS_SCORE: 0

DSS_SCORE: 0.6391

HELIX: 0.0222

FCONS_SCORE: 0

RIG_SCORE: 0.6427

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P722A	TCGA-A5-A0GP	UCEC	TCGA	PTPTVS	DEG_SCF_FBW7_1	0.7503
p.T723A	TCGA-B5-A0JY	UCEC	TCGA	PTPTVS	DEG_SCF_FBW7_1	0.7139
p.T723A	DO43041	UCEC	ICGC	PTPTVS	DEG_SCF_FBW7_1	0.7139
p.S729F	TCGA-FI-A2D5	UCEC	TCGA	PTPTVS	DEG_SCF_FBW7_1	0.2778
p.D726N	DO233725	GACA	ICGC	PTPTVS	DEG_SCF_FBW7_1	0.6932
p.T719M	DO49159	PACA	ICGC	PTPTVS	DEG_SCF_FBW7_1	0.25
p.V726F	DO51148	PRAD	ICGC	PTPTVS	DEG_SCF_FBW7_1	0.5957
p.Q733H	DO43306	UCEC	ICGC	PTPTVS	DEG_SCF_FBW7_1	0.1667
p.M730L	TE-5	oesophagus	COSMIC	PTPTVS	DEG_SCF_FBW7_1	0.25
p.Q719H	NCI-H187	lung	COSMIC	PTPTVS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5HYW2	NHS-like protein 2	DEG_SCF_FBW7_1	722:727	PTPTVS	FBXW7	0.9927	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons