DegronMD

Uniprot ID: Q5HYW2

Source protein: NHS-like protein 2

Source gene: NHSL2

Class: DEG_SCF_FBW7_1

Location: 400:405

E3 ligase: FBXW7

DEGRON score: 0.9931

ASA_SCORE: 78.6333

COIL: 0.8908

CONS_SCORE: 0.7493

DSS_SCORE: 0.4869

HELIX: 0.0677

FCONS_SCORE: 1.3138

RIG_SCORE: 0.7369

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q407H	TCGA-CN-6010	HNSC	TCGA	MTPSAT	DEG_SCF_FBW7_1	0.2778
p.Q407H	DO14766	HNSC	ICGC	MTPSAT	DEG_SCF_FBW7_1	0.2778
p.F403L	DO9002	COAD	ICGC	MTPSAT	DEG_SCF_FBW7_1	0.6981
p.F403L	DO43306	UCEC	ICGC	MTPSAT	DEG_SCF_FBW7_1	0.6981
p.L409I	DO8264	COAD	ICGC	MTPSAT	DEG_SCF_FBW7_1	0.2222
p.A391S	DO229037	LICA	ICGC	MTPSAT	DEG_SCF_FBW7_1	0.0833
p.W412L	DO47278	SKCM	ICGC	MTPSAT	DEG_SCF_FBW7_1	0.1389
p.Q402P	DO40884	UCEC	ICGC	MTPSAT	DEG_SCF_FBW7_1	0.7035
p.D397Y	DO50076	UCEC	ICGC	MTPSAT	DEG_SCF_FBW7_1	0.25
p.P399S	ACH-000810	Skin Cancer	CCLE	MTPSAT	DEG_SCF_FBW7_1	0.75
p.P399S	SK-MEL-30	skin	COSMIC	MTPSAT	DEG_SCF_FBW7_1	0.75
p.K400E	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	MTPSAT	DEG_SCF_FBW7_1	0.7022
p.E393K	CP67-MEL	skin	COSMIC	MTPSAT	DEG_SCF_FBW7_1	0.25
p.A409T	SNU-1040	large_intestine	COSMIC	MTPSAT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5HYW2	NHS-like protein 2	DEG_SCF_FBW7_1	400:405	MTPSAT	FBXW7	0.9931	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons