DegronMD

Uniprot ID: Q5HYW2

Source protein: NHS-like protein 2

Source gene: NHSL2

Class: DEG_SPOP_SBC_1

Location: 308:312

E3 ligase: SPOP

DEGRON score: 0.9682

ASA_SCORE: 81.46

COIL: 0.7442

CONS_SCORE: 0.8872

DSS_SCORE: 0.688

HELIX: 0.0216

FCONS_SCORE: 1.0342

RIG_SCORE: 0.6262

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P322T	TCGA-DD-AADB	LIHC	TCGA	AHSTT	DEG_SPOP_SBC_1	0.0556
p.P322T	DO52229	LIHC	ICGC	AHSTT	DEG_SPOP_SBC_1	0.0556
p.A308S	DO232012	LICA	ICGC	AHSTT	DEG_SPOP_SBC_1	0.7588
p.V321D	DO231646	LINC	ICGC	AHSTT	DEG_SPOP_SBC_1	0.0833
p.A318T	ACH-000999	Colon/Colorectal Cancer	CCLE	AHSTT	DEG_SPOP_SBC_1	0.1667
p.A318T	SNU-1040	large_intestine	COSMIC	AHSTT	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60336	Mitogen-activated protein kinase-binding protein 1	DEG_SPOP_SBC_1	1337:1341	AHSTT	SPOP	0.9106	More...
Q14865	AT-rich interactive domain-containing protein 5B	DEG_SPOP_SBC_1	925:929	AHSTT	SPOP	0.857	More...
Q5HYW2	NHS-like protein 2	DEG_SPOP_SBC_1	308:312	AHSTT	SPOP	0.9682	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons