DegronMD

Uniprot ID: O60336

Source protein: Mitogen-activated protein kinase-binding protein 1

Source gene: MAPKBP1

Class: DEG_SPOP_SBC_1

Location: 1337:1341

E3 ligase: SPOP

DEGRON score: 0.9106

ASA_SCORE: 69.3

COIL: 0.738

CONS_SCORE: 0.2152

DSS_SCORE: 0.4511

HELIX: 0.209

FCONS_SCORE: 1.0185

RIG_SCORE: 0.7196

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1328S	TCGA-BR-4370	STAD	TCGA	AHSTT	DEG_SPOP_SBC_1	0.0833
p.P1331S	TCGA-EE-A3J7	SKCM	TCGA	AHSTT	DEG_SPOP_SBC_1	0.1667
p.E1342K	TCGA-K4-A5RJ	BLCA	TCGA	AHSTT	DEG_SPOP_SBC_1	0.3056
p.E1336K	DO49784	BLCA	ICGC	AHSTT	DEG_SPOP_SBC_1	0.3056
p.E1343K	DO220823	BRCA	ICGC	AHSTT	DEG_SPOP_SBC_1	0.2778
p.G1344C	DO229013	COCA	ICGC	AHSTT	DEG_SPOP_SBC_1	0.25
p.E1343D	DO229018	LICA	ICGC	AHSTT	DEG_SPOP_SBC_1	0.2778
p.G1350C	SIDM00353	Other Sarcomas	GDSC	AHSTT	DEG_SPOP_SBC_1	0.0833
p.G1350C	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	AHSTT	DEG_SPOP_SBC_1	0.0833
p.G1350C	SIDM00544	Neuroblastoma	GDSC	AHSTT	DEG_SPOP_SBC_1	0.0833
p.G1350C	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	AHSTT	DEG_SPOP_SBC_1	0.0833
p.G1350C	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	AHSTT	DEG_SPOP_SBC_1	0.0833
p.G1350C	SIDM00587	Biliary Tract Carcinoma	GDSC	AHSTT	DEG_SPOP_SBC_1	0.0833
p.G1350C	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	AHSTT	DEG_SPOP_SBC_1	0.0833
p.G1350C	SIDM01617	Endometrial Carcinoma	GDSC	AHSTT	DEG_SPOP_SBC_1	0.0833
p.G1350C	SIDM01779	Gastric Carcinoma	GDSC	AHSTT	DEG_SPOP_SBC_1	0.0833
p.G1350C	SIDM01559	Melanoma	GDSC	AHSTT	DEG_SPOP_SBC_1	0.0833
p.C1346Y	SIDM00690	Head and Neck Carcinoma	GDSC	AHSTT	DEG_SPOP_SBC_1	0.1944
p.C1346Y	JHU-029	upper_aerodigestive_tract	COSMIC	AHSTT	DEG_SPOP_SBC_1	0.1944
p.C1340Y	ACH-002251	Head and Neck Cancer	CCLE	AHSTT	DEG_SPOP_SBC_1	0.7087
p.C1340Y	JHU-029	upper_aerodigestive_tract	COSMIC	AHSTT	DEG_SPOP_SBC_1	0.7087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60336	Mitogen-activated protein kinase-binding protein 1	DEG_SPOP_SBC_1	1337:1341	AHSTT	SPOP	0.9106	More...
Q14865	AT-rich interactive domain-containing protein 5B	DEG_SPOP_SBC_1	925:929	AHSTT	SPOP	0.857	More...
Q5HYW2	NHS-like protein 2	DEG_SPOP_SBC_1	308:312	AHSTT	SPOP	0.9682	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons