DegronMD

Uniprot ID: Q14865

Source protein: AT-rich interactive domain-containing protein 5B

Source gene: ARID5B

Class: DEG_SPOP_SBC_1

Location: 925:929

E3 ligase: SPOP

DEGRON score: 0.857

ASA_SCORE: 82.96

COIL: 0.8806

CONS_SCORE: 0.2813

DSS_SCORE: 0.6443

HELIX: 0.0586

FCONS_SCORE: 0.8751

RIG_SCORE: 0.6498

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S934G	TCGA-EI-6882	READ	TCGA	AHSTT	DEG_SPOP_SBC_1	0.1944
p.S933C	DO1132	BRCA	ICGC	AHSTT	DEG_SPOP_SBC_1	0.2222
p.A930S	DO229029	LICA	ICGC	AHSTT	DEG_SPOP_SBC_1	0.3056
p.Q928E	DO52212	LIHC	ICGC	AHSTT	DEG_SPOP_SBC_1	0.6744
p.F931C	DO222638	MELA	ICGC	AHSTT	DEG_SPOP_SBC_1	0.2778
p.P932L	DO37422	SKCM	ICGC	AHSTT	DEG_SPOP_SBC_1	0.25
p.P921S	DO48726	SKCM	ICGC	AHSTT	DEG_SPOP_SBC_1	0.2222
p.S938F	SIDM00221	Melanoma	GDSC	AHSTT	DEG_SPOP_SBC_1	0.0833
p.S938F	ACH-002388	Skin Cancer	CCLE	AHSTT	DEG_SPOP_SBC_1	0.0833
p.V921F	ACH-001197	Lymphoma	CCLE	AHSTT	DEG_SPOP_SBC_1	0.2222
p.S933F	CP66-MEL	skin	COSMIC	AHSTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60336	Mitogen-activated protein kinase-binding protein 1	DEG_SPOP_SBC_1	1337:1341	AHSTT	SPOP	0.9106	More...
Q14865	AT-rich interactive domain-containing protein 5B	DEG_SPOP_SBC_1	925:929	AHSTT	SPOP	0.857	More...
Q5HYW2	NHS-like protein 2	DEG_SPOP_SBC_1	308:312	AHSTT	SPOP	0.9682	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons