DegronMD - Q8NEP3(DNAAF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D681N	TCGA-06-5416	GBM	TCGA	PLTSS	DEG_SPOP_SBC_1	671:675	Mutation rewiring degron network	0.1667
p.D681N	DO10880	GBM	ICGC	PLTSS	DEG_SPOP_SBC_1	671:675	Mutation rewiring degron network	0.1667
p.L587P	TCGA-AD-A5EJ	COAD	TCGA	DPELDYTSLP	CBL_PTK	584:593	Mutation altering degron motif	0.6471
p.L587P	DO50090	COAD	ICGC	DPELDYTSLP	CBL_PTK	584:593	Mutation altering degron motif	0.6471
p.E586K	TCGA-BB-4227	HNSC	TCGA	DPELDYTSLP	CBL_PTK	584:593	Mutation altering degron motif	0.591
p.E586K	DO15855	HNSC	ICGC	DPELDYTSLP	CBL_PTK	584:593	Mutation altering degron motif	0.591
p.T600A	TCGA-CA-6717	COAD	TCGA	DPELDYTSLP	CBL_PTK	584:593	Mutation rewiring degron network	0.1389
p.T600A	DO8264	COAD	ICGC	DPELDYTSLP	CBL_PTK	584:593	Mutation rewiring degron network	0.1389
p.L592I	TCGA-D7-8575	STAD	TCGA	DPELDYTSLP	CBL_PTK	584:593	Mutation altering degron motif	0.6063
p.L592I	DO47755	STAD	ICGC	DPELDYTSLP	CBL_PTK	584:593	Mutation altering degron motif	0.6063
p.L683I	TCGA-FS-A1ZG	SKCM	TCGA	PLTSS	DEG_SPOP_SBC_1	671:675	Mutation rewiring degron network	0.1111
p.L683I	DO37523	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	671:675	Mutation rewiring degron network	0.1111
p.S675T	DO229010	COCA	ICGC	PLTSS	DEG_SPOP_SBC_1	671:675	Mutation altering degron motif	0.6005
p.S675T	DO229013	COCA	ICGC	PLTSS	DEG_SPOP_SBC_1	671:675	Mutation altering degron motif	0.6005
p.S675T	DO229016	COCA	ICGC	PLTSS	DEG_SPOP_SBC_1	671:675	Mutation altering degron motif	0.6005
p.S675T	DO229005	COCA	ICGC	PLTSS	DEG_SPOP_SBC_1	671:675	Mutation altering degron motif	0.6005
p.S675T	DO228947	LICA	ICGC	PLTSS	DEG_SPOP_SBC_1	671:675	Mutation altering degron motif	0.6005
p.S675T	DO230934	LUSC	ICGC	PLTSS	DEG_SPOP_SBC_1	671:675	Mutation altering degron motif	0.6005
p.S675T	DO230999	LUSC	ICGC	PLTSS	DEG_SPOP_SBC_1	671:675	Mutation altering degron motif	0.6005
p.D601Y	DO228976	LICA	ICGC	DPELDYTSLP	CBL_PTK	584:593	Mutation rewiring degron network	0.1111
p.S577L	DO50735	ORCA	ICGC	DPELDYTSLP	CBL_PTK	584:593	Mutation rewiring degron network	0.1389
p.L595V	DO51474	PACA	ICGC	DPELDYTSLP	CBL_PTK	584:593	Mutation rewiring degron network	0.2778
p.D584N	SIDM00194	Colorectal Carcinoma	GDSC	DPELDYTSLP	CBL_PTK	584:593	Mutation altering degron motif	0.5821
p.D584N	SIDM00557	Neuroblastoma	GDSC	DPELDYTSLP	CBL_PTK	584:593	Mutation altering degron motif	0.5821
p.D584N	SIDM00338	Acute Myeloid Leukemia	GDSC	DPELDYTSLP	CBL_PTK	584:593	Mutation altering degron motif	0.5821
p.D584N	SIDM00064	Hepatocellular Carcinoma	GDSC	DPELDYTSLP	CBL_PTK	584:593	Mutation altering degron motif	0.5821
p.D584N	SIDM00362	Burkitt's Lymphoma	GDSC	DPELDYTSLP	CBL_PTK	584:593	Mutation altering degron motif	0.5821
p.D584N	SIDM00193	Colorectal Carcinoma	GDSC	DPELDYTSLP	CBL_PTK	584:593	Mutation altering degron motif	0.5821
p.D584N	SIDM00410	Other Blood Cancers	GDSC	DPELDYTSLP	CBL_PTK	584:593	Mutation altering degron motif	0.5821
p.D584N	SIDM00239	Kidney Carcinoma	GDSC	DPELDYTSLP	CBL_PTK	584:593	Mutation altering degron motif	0.5821
p.D584N	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	DPELDYTSLP	CBL_PTK	584:593	Mutation altering degron motif	0.5821
p.D584N	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	DPELDYTSLP	CBL_PTK	584:593	Mutation altering degron motif	0.5821
p.D584N	SIDM00165	Other Solid Cancers	GDSC	DPELDYTSLP	CBL_PTK	584:593	Mutation altering degron motif	0.5821
p.D584N	SIDM01393	Gastric Carcinoma	GDSC	DPELDYTSLP	CBL_PTK	584:593	Mutation altering degron motif	0.5821
p.D584N	SIDM01494	Glioblastoma	GDSC	DPELDYTSLP	CBL_PTK	584:593	Mutation altering degron motif	0.5821
p.D584N	SIDM01694	B-Lymphoblastic Leukemia	GDSC	DPELDYTSLP	CBL_PTK	584:593	Mutation altering degron motif	0.5821
p.V575I	SIDM00491	Thyroid Gland Carcinoma	GDSC	DPELDYTSLP	CBL_PTK	584:593	Mutation rewiring degron network	0.0833
p.V575I	ACH-001443	Thyroid Cancer	CCLE	DPELDYTSLP	CBL_PTK	584:593	Mutation rewiring degron network	0.0833
p.V575I	ASH-3	thyroid	COSMIC	DPELDYTSLP	CBL_PTK	584:593	Mutation rewiring degron network	0.0833
p.L603P	SIDM00273	Glioblastoma	GDSC	DPELDYTSLP	CBL_PTK	584:593	Mutation rewiring degron network	0.0556
p.L603P	ACH-000756	Brain Cancer	CCLE	DPELDYTSLP	CBL_PTK	584:593	Mutation rewiring degron network	0.0556
p.L603P	GI-1	central nervous system	COSMIC	DPELDYTSLP	CBL_PTK	584:593	Mutation rewiring degron network	0.0556
p.T664A	SIDM01622	Breast Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	671:675	Mutation rewiring degron network	0.1389
p.T664A	ACH-000721	Breast Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	671:675	Mutation rewiring degron network	0.1389
p.T664A	ACH-001864	Bile Duct Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	671:675	Mutation rewiring degron network	0.1389

Kaplan plot for DNAAF1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNAAF1

UniProt ID: Q8NEP3

Entrez ID: 123872

Protein name: Dynein axonemal assembly factor 1 (Leucine-rich repeat-containing protein 50)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DNAAF1 in