DegronMD

Uniprot ID: Q8NEP3

Source protein: Dynein axonemal assembly factor 1

Source gene: DNAAF1

Class: CBL_PTK

Location: 584:593

E3 ligase: CBL

DEGRON score: 0.9227

ASA_SCORE: 88.31

COIL: 0.7714

CONS_SCORE: 0.3407

DSS_SCORE: 0.4326

HELIX: 0.1993

FCONS_SCORE: 1.0394

RIG_SCORE: 0.7717

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L587P	TCGA-AD-A5EJ	COAD	TCGA	DPELDYTSLP	CBL_PTK	0.6471
p.L587P	DO50090	COAD	ICGC	DPELDYTSLP	CBL_PTK	0.6471
p.E586K	TCGA-BB-4227	HNSC	TCGA	DPELDYTSLP	CBL_PTK	0.591
p.E586K	DO15855	HNSC	ICGC	DPELDYTSLP	CBL_PTK	0.591
p.T600A	TCGA-CA-6717	COAD	TCGA	DPELDYTSLP	CBL_PTK	0.1389
p.T600A	DO8264	COAD	ICGC	DPELDYTSLP	CBL_PTK	0.1389
p.L592I	TCGA-D7-8575	STAD	TCGA	DPELDYTSLP	CBL_PTK	0.6063
p.L592I	DO47755	STAD	ICGC	DPELDYTSLP	CBL_PTK	0.6063
p.D601Y	DO228976	LICA	ICGC	DPELDYTSLP	CBL_PTK	0.1111
p.S577L	DO50735	ORCA	ICGC	DPELDYTSLP	CBL_PTK	0.1389
p.L595V	DO51474	PACA	ICGC	DPELDYTSLP	CBL_PTK	0.2778
p.D584N	SIDM00194	Colorectal Carcinoma	GDSC	DPELDYTSLP	CBL_PTK	0.5821
p.D584N	SIDM00557	Neuroblastoma	GDSC	DPELDYTSLP	CBL_PTK	0.5821
p.D584N	SIDM00338	Acute Myeloid Leukemia	GDSC	DPELDYTSLP	CBL_PTK	0.5821
p.D584N	SIDM00064	Hepatocellular Carcinoma	GDSC	DPELDYTSLP	CBL_PTK	0.5821
p.D584N	SIDM00362	Burkitt's Lymphoma	GDSC	DPELDYTSLP	CBL_PTK	0.5821
p.D584N	SIDM00193	Colorectal Carcinoma	GDSC	DPELDYTSLP	CBL_PTK	0.5821
p.D584N	SIDM00410	Other Blood Cancers	GDSC	DPELDYTSLP	CBL_PTK	0.5821
p.D584N	SIDM00239	Kidney Carcinoma	GDSC	DPELDYTSLP	CBL_PTK	0.5821
p.D584N	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	DPELDYTSLP	CBL_PTK	0.5821
p.D584N	SIDM00902	Non-Small Cell Lung Carcinoma	GDSC	DPELDYTSLP	CBL_PTK	0.5821
p.D584N	SIDM00165	Other Solid Cancers	GDSC	DPELDYTSLP	CBL_PTK	0.5821
p.D584N	SIDM01393	Gastric Carcinoma	GDSC	DPELDYTSLP	CBL_PTK	0.5821
p.D584N	SIDM01494	Glioblastoma	GDSC	DPELDYTSLP	CBL_PTK	0.5821
p.D584N	SIDM01694	B-Lymphoblastic Leukemia	GDSC	DPELDYTSLP	CBL_PTK	0.5821
p.V575I	SIDM00491	Thyroid Gland Carcinoma	GDSC	DPELDYTSLP	CBL_PTK	0.0833
p.V575I	ACH-001443	Thyroid Cancer	CCLE	DPELDYTSLP	CBL_PTK	0.0833
p.V575I	ASH-3	thyroid	COSMIC	DPELDYTSLP	CBL_PTK	0.0833
p.L603P	SIDM00273	Glioblastoma	GDSC	DPELDYTSLP	CBL_PTK	0.0556
p.L603P	ACH-000756	Brain Cancer	CCLE	DPELDYTSLP	CBL_PTK	0.0556
p.L603P	GI-1	central_nervous_system	COSMIC	DPELDYTSLP	CBL_PTK	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DPELDYTSLP

Degron related mutations and impact score

Drug responses associated with DNAAF1 mutations

All proteins holding degron of DPELDYTSLP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEP3	Dynein axonemal assembly factor 1	CBL_PTK	584:593	DPELDYTSLP	CBL	0.9227	More...