DegronMD - Q17RY0(CPEB4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y288C	TCGA-22-4599	LUSC	TCGA	PSPTPSSS	DEG_SCF_FBW7_1	291:298	Mutation rewiring degron network	0.25
p.Y288C	DO26945	LUSC	ICGC	PSPTPSSS	DEG_SCF_FBW7_1	291:298	Mutation rewiring degron network	0.25
p.G167C	TCGA-60-2726	LUSC	TCGA	PLTSS	DEG_SPOP_SBC_1	157:161	Mutation rewiring degron network	0.1667
p.G167C	TCGA-60-2726	LUSC	TCGA	APSSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.0833
p.G167C	TCGA-ER-A19B	SKCM	TCGA	PLTSS	DEG_SPOP_SBC_1	157:161	Mutation rewiring degron network	0.1667
p.G167C	TCGA-ER-A19B	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.0833
p.G167C	DO27484	LUSC	ICGC	PLTSS	DEG_SPOP_SBC_1	157:161	Mutation rewiring degron network	0.1667
p.G167C	DO27484	LUSC	ICGC	APSSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.0833
p.G167C	DO47491	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	157:161	Mutation rewiring degron network	0.1667
p.G167C	DO47491	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.0833
p.L321P	TCGA-AA-3854	COAD	TCGA	ITPLNS	DEG_SCF_FBW7_1	325:330	Mutation rewiring degron network	0.2222
p.L321P	DO10148	COAD	ICGC	ITPLNS	DEG_SCF_FBW7_1	325:330	Mutation rewiring degron network	0.2222
p.L321P	DO223068	ESCA	ICGC	ITPLNS	DEG_SCF_FBW7_1	325:330	Mutation rewiring degron network	0.2222
p.A162T	TCGA-AA-3949	COAD	TCGA	PLTSS	DEG_SPOP_SBC_1	157:161	Mutation rewiring degron network	0.3056
p.A162T	TCGA-FI-A2D5	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	157:161	Mutation rewiring degron network	0.3056
p.A162T	DO7798	COAD	ICGC	PLTSS	DEG_SPOP_SBC_1	157:161	Mutation rewiring degron network	0.3056
p.A162T	DO41331	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	157:161	Mutation rewiring degron network	0.3056
p.D382N	TCGA-AN-A046	BRCA	TCGA	IFPFPD	LIG_APCC_ABBA_1	371:376	Mutation rewiring degron network	0.1667
p.D382N	TCGA-CA-6717	COAD	TCGA	IFPFPD	LIG_APCC_ABBA_1	371:376	Mutation rewiring degron network	0.1667
p.D382N	DO1285	BRCA	ICGC	IFPFPD	LIG_APCC_ABBA_1	371:376	Mutation rewiring degron network	0.1667
p.D382N	DO8264	COAD	ICGC	IFPFPD	LIG_APCC_ABBA_1	371:376	Mutation rewiring degron network	0.1667
p.R367M	TCGA-BF-A1PZ	SKCM	TCGA	IFPFPD	LIG_APCC_ABBA_1	371:376	Mutation rewiring degron network	0.2222
p.R367M	DO50279	SKCM	ICGC	IFPFPD	LIG_APCC_ABBA_1	371:376	Mutation rewiring degron network	0.2222
p.R377G	TCGA-CN-A63W	HNSC	TCGA	IFPFPD	LIG_APCC_ABBA_1	371:376	Mutation rewiring degron network	0.3056
p.R377G	DO49031	HNSC	ICGC	IFPFPD	LIG_APCC_ABBA_1	371:376	Mutation rewiring degron network	0.3056
p.K335N	TCGA-D1-A103	UCEC	TCGA	ITPLNS	DEG_SCF_FBW7_1	325:330	Mutation substituting flanking lysine	0.3056
p.K335N	DO42312	UCEC	ICGC	ITPLNS	DEG_SCF_FBW7_1	325:330	Mutation substituting flanking lysine	0.3056
p.G320W	TCGA-EO-A22R	UCEC	TCGA	ITPLNS	DEG_SCF_FBW7_1	325:330	Mutation rewiring degron network	0.1944
p.G320W	DO42713	UCEC	ICGC	ITPLNS	DEG_SCF_FBW7_1	325:330	Mutation rewiring degron network	0.1944
p.G152C	TCGA-ER-A19B	SKCM	TCGA	PLTSS	DEG_SPOP_SBC_1	157:161	Mutation rewiring degron network	0.1944
p.G152C	DO47491	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	157:161	Mutation rewiring degron network	0.1944
p.L158S	TCGA-F4-6570	COAD	TCGA	PLTSS	DEG_SPOP_SBC_1	157:161	Mutation altering degron motif	0.6556
p.L158S	DO10443	COAD	ICGC	PLTSS	DEG_SPOP_SBC_1	157:161	Mutation altering degron motif	0.6556
p.R318H	TCGA-FI-A2D5	UCEC	TCGA	ITPLNS	DEG_SCF_FBW7_1	325:330	Mutation rewiring degron network	0.1389
p.R318H	DO41331	UCEC	ICGC	ITPLNS	DEG_SCF_FBW7_1	325:330	Mutation rewiring degron network	0.1389
p.G303C	TCGA-FS-A1YW	SKCM	TCGA	PSPTPSSS	DEG_SCF_FBW7_1	291:298	Mutation rewiring degron network	0.1944
p.G303C	DO37734	SKCM	ICGC	PSPTPSSS	DEG_SCF_FBW7_1	291:298	Mutation rewiring degron network	0.1944
p.D186A	TCGA-GS-A9TZ	DLBC	TCGA	APSSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.1667
p.D186A	DO219918	DLBC	ICGC	APSSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.1667
p.R377C	TCGA-HZ-7925	PAAD	TCGA	IFPFPD	LIG_APCC_ABBA_1	371:376	Mutation rewiring degron network	0.3056
p.R377C	DO32778	PAAD	ICGC	IFPFPD	LIG_APCC_ABBA_1	371:376	Mutation rewiring degron network	0.3056
p.S332L	TCGA-IR-A3LA	CESC	TCGA	ITPLNS	DEG_SCF_FBW7_1	325:330	Mutation blocking phosphorylation signal	0.7222
p.S332L	DO44377	CESC	ICGC	ITPLNS	DEG_SCF_FBW7_1	325:330	Mutation blocking phosphorylation signal	0.7222
p.P157S	DO222596	COCA	ICGC	PLTSS	DEG_SPOP_SBC_1	157:161	Mutation altering degron motif	0.6752
p.D369G	DO228125	EOPC	ICGC	IFPFPD	LIG_APCC_ABBA_1	371:376	Mutation rewiring degron network	0.2778
p.M361I	DO228991	LICA	ICGC	IFPFPD	LIG_APCC_ABBA_1	371:376	Mutation rewiring degron network	0.0556
p.G304V	DO229027	LICA	ICGC	PSPTPSSS	DEG_SCF_FBW7_1	291:298	Mutation rewiring degron network	0.1667
p.R377H	DO228419	MALY	ICGC	IFPFPD	LIG_APCC_ABBA_1	371:376	Mutation rewiring degron network	0.3056
p.S164F	DO232761	PBCA	ICGC	PLTSS	DEG_SPOP_SBC_1	157:161	Mutation rewiring degron network	0.25
p.P157H	SIDM01103	Squamous Cell Lung Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	157:161	Mutation altering degron motif	0.7694
p.P157H	SIDM00327	Hodgkin's Lymphoma	GDSC	PLTSS	DEG_SPOP_SBC_1	157:161	Mutation altering degron motif	0.7694
p.P157H	SIDM00622	Glioblastoma	GDSC	PLTSS	DEG_SPOP_SBC_1	157:161	Mutation altering degron motif	0.7694
p.P157H	SIDM00257	Neuroblastoma	GDSC	PLTSS	DEG_SPOP_SBC_1	157:161	Mutation altering degron motif	0.7694
p.F374V	SIDM01175	Other Sarcomas	GDSC	IFPFPD	LIG_APCC_ABBA_1	371:376	Mutation altering degron motif	0.7068
p.F374V	ACH-002309	Sarcoma	CCLE	IFPFPD	LIG_APCC_ABBA_1	371:376	Mutation altering degron motif	0.7068
p.F374V	SW684	soft tissue	COSMIC	IFPFPD	LIG_APCC_ABBA_1	371:376	Mutation altering degron motif	0.7068
p.R319K	SIDM00465	Ovarian Carcinoma	GDSC	ITPLNS	DEG_SCF_FBW7_1	325:330	Mutation rewiring degron network	0.1667
p.R319K	ACH-002183	Ovarian Cancer	CCLE	ITPLNS	DEG_SCF_FBW7_1	325:330	Mutation rewiring degron network	0.1667
p.R319K	OVMIU	ovary	COSMIC	ITPLNS	DEG_SCF_FBW7_1	325:330	Mutation rewiring degron network	0.1667
p.A176V	SIDM00292	Small Cell Lung Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	176:180	Mutation altering degron motif	0.5825
p.A176V	ACH-002077	Lung Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	176:180	Mutation altering degron motif	0.5825
p.A176V	LU-165	lung	COSMIC	APSSS	DEG_SPOP_SBC_1	176:180	Mutation altering degron motif	0.5825
p.S154A	SIDM00819	Kidney Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	157:161	Mutation rewiring degron network	0.25
p.S154A	ACH-002189	Kidney Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	157:161	Mutation rewiring degron network	0.25
p.S154A	RCC-FG2	kidney	COSMIC	PLTSS	DEG_SPOP_SBC_1	157:161	Mutation rewiring degron network	0.25
p.S364G	SIDM00068	Colorectal Carcinoma	GDSC	IFPFPD	LIG_APCC_ABBA_1	371:376	Mutation rewiring degron network	0.1389
p.P157L	SIDM00743	Non-Small Cell Lung Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	157:161	Mutation altering degron motif	0.7582
p.P157L	ACH-000448	Lung Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	157:161	Mutation altering degron motif	0.7582
p.P157L	NCI-H1666	lung	COSMIC	PLTSS	DEG_SPOP_SBC_1	157:161	Mutation altering degron motif	0.7582
p.G303V	SIDM00168	Head and Neck Carcinoma	GDSC	PSPTPSSS	DEG_SCF_FBW7_1	291:298	Mutation rewiring degron network	0.1944
p.G303V	ACH-000549	Head and Neck Cancer	CCLE	PSPTPSSS	DEG_SCF_FBW7_1	291:298	Mutation rewiring degron network	0.1944
p.A339G	ACH-000436	Myeloma	CCLE	ITPLNS	DEG_SCF_FBW7_1	325:330	Mutation rewiring degron network	0.0833
p.A368T	ACH-000999	Colon/Colorectal Cancer	CCLE	IFPFPD	LIG_APCC_ABBA_1	371:376	Mutation rewiring degron network	0.25
p.E188D	NCI-H69	lung	COSMIC	APSSS	DEG_SPOP_SBC_1	176:180	Mutation rewiring degron network	0.1111
p.R320H	RL95-2	endometrium	COSMIC	ITPLNS	DEG_SCF_FBW7_1	325:330	Mutation rewiring degron network	0.1944
p.G179C	SW1417	large intestine	COSMIC	APSSS	DEG_SPOP_SBC_1	176:180	Mutation altering degron motif	0.76
p.C299G	COLO-684	endometrium	COSMIC	PSPTPSSS	DEG_SCF_FBW7_1	291:298	Mutation rewiring degron network	0.3056
p.R337H	RL95-2	endometrium	COSMIC	ITPLNS	DEG_SCF_FBW7_1	325:330	Mutation rewiring degron network	0.1389
p.E148D	TGBC24TKB	biliary tract	COSMIC	PLTSS	DEG_SPOP_SBC_1	157:161	Mutation rewiring degron network	0.0833
p.V297L	SW156	kidney	COSMIC	PSPTPSSS	DEG_SCF_FBW7_1	291:298	Mutation altering degron motif	0.6765
p.C282G	COLO-684	endometrium	COSMIC	PSPTPSSS	DEG_SCF_FBW7_1	291:298	Mutation rewiring degron network	0.0833

Kaplan plot for CPEB4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CPEB4

UniProt ID: Q17RY0

Entrez ID: 80315

Protein name: Cytoplasmic polyadenylation element-binding protein 4 (CPE-BP4) (CPE-binding protein 4) (hCPEB-4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CPEB4 in