DegronMD

Uniprot ID: Q17RY0

Source protein: Cytoplasmic polyadenylation element-binding protein 4

Source gene: CPEB4

Class: DEG_SCF_FBW7_1

Location: 325:330

E3 ligase: FBXW7

DEGRON score: 0.9995

ASA_SCORE: 68.4

COIL: 0.8728

CONS_SCORE: 0.4276

DSS_SCORE: 0.4783

HELIX: 0.0707

FCONS_SCORE: 1.1865

RIG_SCORE: 0.7348

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L321P	TCGA-AA-3854	COAD	TCGA	ITPLNS	DEG_SCF_FBW7_1	0.2222
p.L321P	DO10148	COAD	ICGC	ITPLNS	DEG_SCF_FBW7_1	0.2222
p.L321P	DO223068	ESCA	ICGC	ITPLNS	DEG_SCF_FBW7_1	0.2222
p.K335N	TCGA-D1-A103	UCEC	TCGA	ITPLNS	DEG_SCF_FBW7_1	0.3056
p.K335N	DO42312	UCEC	ICGC	ITPLNS	DEG_SCF_FBW7_1	0.3056
p.G320W	TCGA-EO-A22R	UCEC	TCGA	ITPLNS	DEG_SCF_FBW7_1	0.1944
p.G320W	DO42713	UCEC	ICGC	ITPLNS	DEG_SCF_FBW7_1	0.1944
p.R318H	TCGA-FI-A2D5	UCEC	TCGA	ITPLNS	DEG_SCF_FBW7_1	0.1389
p.R318H	DO41331	UCEC	ICGC	ITPLNS	DEG_SCF_FBW7_1	0.1389
p.S332L	TCGA-IR-A3LA	CESC	TCGA	ITPLNS	DEG_SCF_FBW7_1	0.7222
p.S332L	DO44377	CESC	ICGC	ITPLNS	DEG_SCF_FBW7_1	0.7222
p.R319K	SIDM00465	Ovarian Carcinoma	GDSC	ITPLNS	DEG_SCF_FBW7_1	0.1667
p.R319K	ACH-002183	Ovarian Cancer	CCLE	ITPLNS	DEG_SCF_FBW7_1	0.1667
p.R319K	OVMIU	ovary	COSMIC	ITPLNS	DEG_SCF_FBW7_1	0.1667
p.A339G	ACH-000436	Myeloma	CCLE	ITPLNS	DEG_SCF_FBW7_1	0.0833
p.R320H	RL95-2	endometrium	COSMIC	ITPLNS	DEG_SCF_FBW7_1	0.1944
p.R337H	RL95-2	endometrium	COSMIC	ITPLNS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q17RY0	Cytoplasmic polyadenylation element-binding protein 4	DEG_SCF_FBW7_1	325:330	ITPLNS	FBXW7	0.9995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons