DegronMD

Uniprot ID: Q17RY0

Source protein: Cytoplasmic polyadenylation element-binding protein 4

Source gene: CPEB4

Class: LIG_APCC_ABBA_1

Location: 371:376

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9797

ASA_SCORE: 69.4333

COIL: 0.904

CONS_SCORE: 0.2924

DSS_SCORE: 0.3845

HELIX: 0.0427

FCONS_SCORE: 0.9229

RIG_SCORE: 0.751

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D382N	TCGA-AN-A046	BRCA	TCGA	IFPFPD	LIG_APCC_ABBA_1	0.1667
p.D382N	TCGA-CA-6717	COAD	TCGA	IFPFPD	LIG_APCC_ABBA_1	0.1667
p.D382N	DO1285	BRCA	ICGC	IFPFPD	LIG_APCC_ABBA_1	0.1667
p.D382N	DO8264	COAD	ICGC	IFPFPD	LIG_APCC_ABBA_1	0.1667
p.R367M	TCGA-BF-A1PZ	SKCM	TCGA	IFPFPD	LIG_APCC_ABBA_1	0.2222
p.R367M	DO50279	SKCM	ICGC	IFPFPD	LIG_APCC_ABBA_1	0.2222
p.R377G	TCGA-CN-A63W	HNSC	TCGA	IFPFPD	LIG_APCC_ABBA_1	0.3056
p.R377G	DO49031	HNSC	ICGC	IFPFPD	LIG_APCC_ABBA_1	0.3056
p.R377C	TCGA-HZ-7925	PAAD	TCGA	IFPFPD	LIG_APCC_ABBA_1	0.3056
p.R377C	DO32778	PAAD	ICGC	IFPFPD	LIG_APCC_ABBA_1	0.3056
p.D369G	DO228125	EOPC	ICGC	IFPFPD	LIG_APCC_ABBA_1	0.2778
p.M361I	DO228991	LICA	ICGC	IFPFPD	LIG_APCC_ABBA_1	0.0556
p.R377H	DO228419	MALY	ICGC	IFPFPD	LIG_APCC_ABBA_1	0.3056
p.F374V	SIDM01175	Other Sarcomas	GDSC	IFPFPD	LIG_APCC_ABBA_1	0.7068
p.F374V	ACH-002309	Sarcoma	CCLE	IFPFPD	LIG_APCC_ABBA_1	0.7068
p.F374V	SW684	soft_tissue	COSMIC	IFPFPD	LIG_APCC_ABBA_1	0.7068
p.S364G	SIDM00068	Colorectal Carcinoma	GDSC	IFPFPD	LIG_APCC_ABBA_1	0.1389
p.A368T	ACH-000999	Colon/Colorectal Cancer	CCLE	IFPFPD	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q17RY0	Cytoplasmic polyadenylation element-binding protein 4	LIG_APCC_ABBA_1	371:376	IFPFPD	APC,CDC20,FZR1	0.9797	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons