DegronMD

Uniprot ID: Q17RY0

Source protein: Cytoplasmic polyadenylation element-binding protein 4

Source gene: CPEB4

Class: DEG_SCF_FBW7_1

Location: 291:298

E3 ligase: FBXW7

DEGRON score: 0.9983

ASA_SCORE: 75.5625

COIL: 0.9543

CONS_SCORE: 0.3829

DSS_SCORE: 0.6151

HELIX: 0.0268

FCONS_SCORE: 1.0911

RIG_SCORE: 0.5232

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V297L	SW156	kidney	COSMIC	PSPTPSSS	DEG_SCF_FBW7_1	0.6765
p.C299G	COLO-684	endometrium	COSMIC	PSPTPSSS	DEG_SCF_FBW7_1	0.3056
p.Y288C	TCGA-22-4599	LUSC	TCGA	PSPTPSSS	DEG_SCF_FBW7_1	0.25
p.Y288C	DO26945	LUSC	ICGC	PSPTPSSS	DEG_SCF_FBW7_1	0.25
p.G303C	TCGA-FS-A1YW	SKCM	TCGA	PSPTPSSS	DEG_SCF_FBW7_1	0.1944
p.G303C	DO37734	SKCM	ICGC	PSPTPSSS	DEG_SCF_FBW7_1	0.1944
p.G303V	SIDM00168	Head and Neck Carcinoma	GDSC	PSPTPSSS	DEG_SCF_FBW7_1	0.1944
p.G303V	ACH-000549	Head and Neck Cancer	CCLE	PSPTPSSS	DEG_SCF_FBW7_1	0.1944
p.G304V	DO229027	LICA	ICGC	PSPTPSSS	DEG_SCF_FBW7_1	0.1667
p.C282G	COLO-684	endometrium	COSMIC	PSPTPSSS	DEG_SCF_FBW7_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q17RY0	Cytoplasmic polyadenylation element-binding protein 4	DEG_SCF_FBW7_1	291:298	PSPTPSSS	FBXW7	0.9983	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons