DegronMD - O94880(PHF14)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P180L	TCGA-29-1691	OV	TCGA	NRPLLDFVS	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.1111
p.P180L	TCGA-29-1691	OV	TCGA	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.0556
p.P180L	DO32133	OV	ICGC	NRPLLDFVS	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.1111
p.P180L	DO32133	OV	ICGC	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.0556
p.M203I	TCGA-49-AARN	LUAD	TCGA	NRPLLDFVS	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.1389
p.M203I	TCGA-A5-A1OF	UCEC	TCGA	NRPLLDFVS	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.1389
p.M203I	DO218923	LUAD	ICGC	NRPLLDFVS	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.1389
p.M203I	DO42568	UCEC	ICGC	NRPLLDFVS	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.1389
p.S53I	TCGA-85-A4JC	LUSC	TCGA	DSGEGS	DEG_SCF_TRCP1_1	52:57	Mutation altering degron motif	0.8453
p.S53I	DO45429	LUSC	ICGC	DSGEGS	DEG_SCF_TRCP1_1	52:57	Mutation altering degron motif	0.8453
p.E563G	TCGA-A6-6780	COAD	TCGA	PLTSS	DEG_SPOP_SBC_1	568:572	Mutation rewiring degron network	0.1944
p.R189Q	TCGA-AJ-A3EK	UCEC	TCGA	NRPLLDFVS	DEG_APCC_DBOX_1	188:196	Mutation altering degron motif	0.7329
p.R189Q	DO41584	UCEC	ICGC	NRPLLDFVS	DEG_APCC_DBOX_1	188:196	Mutation altering degron motif	0.7329
p.R189Q	SIDM00531	Pancreatic Carcinoma	GDSC	NRPLLDFVS	DEG_APCC_DBOX_1	188:196	Mutation altering degron motif	0.7329
p.R189Q	HuP-T4	pancreas	COSMIC	NRPLLDFVS	DEG_APCC_DBOX_1	188:196	Mutation altering degron motif	0.7329
p.A172T	TCGA-AP-A051	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.2778
p.A172T	TCGA-D1-A103	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.2778
p.A172T	DO42312	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.2778
p.A172T	DO42673	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.2778
p.E55D	TCGA-BR-4257	STAD	TCGA	DSGEGS	DEG_SCF_TRCP1_1	52:57	Mutation altering degron motif	0.5647
p.E55D	DO38683	STAD	ICGC	DSGEGS	DEG_SCF_TRCP1_1	52:57	Mutation altering degron motif	0.5647
p.K564N	TCGA-CM-5861	COAD	TCGA	PLTSS	DEG_SPOP_SBC_1	568:572	Mutation substituting flanking lysine	0.3333
p.R577H	TCGA-DU-6392	LGG	TCGA	PLTSS	DEG_SPOP_SBC_1	568:572	Mutation rewiring degron network	0.1944
p.R577H	TCGA-FD-A3N6	BLCA	TCGA	PLTSS	DEG_SPOP_SBC_1	568:572	Mutation rewiring degron network	0.1944
p.R577H	TCGA-VQ-A8PZ	STAD	TCGA	PLTSS	DEG_SPOP_SBC_1	568:572	Mutation rewiring degron network	0.1944
p.P561S	TCGA-EE-A29D	SKCM	TCGA	PLTSS	DEG_SPOP_SBC_1	568:572	Mutation rewiring degron network	0.1389
p.A575D	TCGA-EE-A3AC	SKCM	TCGA	PLTSS	DEG_SPOP_SBC_1	568:572	Mutation rewiring degron network	0.25
p.R577C	TCGA-EE-A3J5	SKCM	TCGA	PLTSS	DEG_SPOP_SBC_1	568:572	Mutation rewiring degron network	0.1944
p.E179K	TCGA-EO-A3AV	UCEC	TCGA	NRPLLDFVS	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.0833
p.E179K	TCGA-EO-A3AV	UCEC	TCGA	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.0833
p.E179K	DO222762	COCA	ICGC	NRPLLDFVS	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.0833
p.E179K	DO222762	COCA	ICGC	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.0833
p.E179K	DO52412	UCEC	ICGC	NRPLLDFVS	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.0833
p.E179K	DO52412	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.0833
p.G43C	TCGA-ER-A195	SKCM	TCGA	DSGEGS	DEG_SCF_TRCP1_1	52:57	Mutation rewiring degron network	0.0833
p.G43C	DO47712	SKCM	ICGC	DSGEGS	DEG_SCF_TRCP1_1	52:57	Mutation rewiring degron network	0.0833
p.D205A	TCGA-FI-A2D5	UCEC	TCGA	NRPLLDFVS	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.0833
p.D205A	DO41331	UCEC	ICGC	NRPLLDFVS	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.0833
p.S165F	TCGA-VR-A8EX	ESCA	TCGA	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.3056
p.E55K	DO1073	BRCA	ICGC	DSGEGS	DEG_SCF_TRCP1_1	52:57	Mutation altering degron motif	0.591
p.E200D	DO44096	COAD	ICGC	NRPLLDFVS	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.2222
p.D174V	DO7798	COAD	ICGC	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.2222
p.G191A	DO8479	COAD	ICGC	NRPLLDFVS	DEG_APCC_DBOX_1	188:196	Mutation altering degron motif	0.754
p.T169M	DO222794	COCA	ICGC	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation altering degron motif	0.7423
p.T169M	DO222842	COCA	ICGC	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation altering degron motif	0.7423
p.D174Y	DO234303	ESAD	ICGC	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.2222
p.S178G	DO223053	ESCA	ICGC	NRPLLDFVS	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.0556
p.S178G	DO223053	ESCA	ICGC	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.1111
p.V169F	DO44448	HNSC	ICGC	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation altering degron motif	0.7068
p.C178F	DO228976	LICA	ICGC	NRPLLDFVS	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.0556
p.C178F	DO228976	LICA	ICGC	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.1111
p.G58C	DO229019	LICA	ICGC	DSGEGS	DEG_SCF_TRCP1_1	52:57	Mutation rewiring degron network	0.3056
p.S172I	DO229029	LICA	ICGC	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.2778
p.H62R	DO48532	LIHC	ICGC	DSGEGS	DEG_SCF_TRCP1_1	52:57	Mutation rewiring degron network	0.1944
p.K189R	DO231827	LINC	ICGC	NRPLLDFVS	DEG_APCC_DBOX_1	188:196	Mutation altering degron motif	0.7237
p.R163C	DO25622	LUAD	ICGC	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation blocking phosphorylation signal	0.6944
p.R163C	DO37406	SKCM	ICGC	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation blocking phosphorylation signal	0.6944
p.R163C	DO223286	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation blocking phosphorylation signal	0.6944
p.E200Q	DO23798	LUAD	ICGC	NRPLLDFVS	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.2222
p.C173F	DO23744	LUAD	ICGC	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.25
p.A49S	DO27899	ORCA	ICGC	DSGEGS	DEG_SCF_TRCP1_1	52:57	Mutation rewiring degron network	0.25
p.G58D	DO232761	PBCA	ICGC	DSGEGS	DEG_SCF_TRCP1_1	52:57	Mutation rewiring degron network	0.3056
p.S172R	DO36556	READ	ICGC	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.2778
p.P577H	DO37523	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	568:572	Mutation rewiring degron network	0.1944
p.K576R	DO37421	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	568:572	Mutation rewiring degron network	0.2222
p.E565K	DO47646	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	568:572	Mutation rewiring degron network	0.25
p.G168W	DO51236	SKCM	ICGC	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation altering degron motif	0.7825
p.D581Y	DO43186	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	568:572	Mutation rewiring degron network	0.0833
p.R561I	DO41572	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	568:572	Mutation rewiring degron network	0.1389
p.C178Y	DO52424	UCEC	ICGC	NRPLLDFVS	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.0556
p.C178Y	DO52424	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.1111
p.R163H	DO42608	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation blocking phosphorylation signal	0.6944
p.T167A	DO41235	UCEC	ICGC	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation altering degron motif	0.7139
p.R581Q	SIDM01314	Colorectal Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	568:572	Mutation rewiring degron network	0.0833
p.A49P	SIDM00845	Burkitt's Lymphoma	GDSC	DSGEGS	DEG_SCF_TRCP1_1	52:57	Mutation rewiring degron network	0.25
p.A49P	SIDM00461	Acute Myeloid Leukemia	GDSC	DSGEGS	DEG_SCF_TRCP1_1	52:57	Mutation rewiring degron network	0.25
p.A49P	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DSGEGS	DEG_SCF_TRCP1_1	52:57	Mutation rewiring degron network	0.25
p.A49P	SIDM01519	Head and Neck Carcinoma	GDSC	DSGEGS	DEG_SCF_TRCP1_1	52:57	Mutation rewiring degron network	0.25
p.A49P	ACH-000786	Lymphoma	CCLE	DSGEGS	DEG_SCF_TRCP1_1	52:57	Mutation rewiring degron network	0.25
p.A49P	ACH-000992	Head and Neck Cancer	CCLE	DSGEGS	DEG_SCF_TRCP1_1	52:57	Mutation rewiring degron network	0.25
p.A49P	Daudi	haematopoietic and lymphoid tissue	COSMIC	DSGEGS	DEG_SCF_TRCP1_1	52:57	Mutation rewiring degron network	0.25
p.A159V	SIDM00516	Melanoma	GDSC	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.1389
p.A159V	ACH-002166	Skin Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.1389
p.A159V	MZ7-mel	skin	COSMIC	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.1389
p.S163F	SIDM00852	Glioma	GDSC	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation blocking phosphorylation signal	0.6944
p.S163F	H4	central nervous system	COSMIC	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation blocking phosphorylation signal	0.6944
p.R187Q	SIDM00217	Colorectal Carcinoma	GDSC	NRPLLDFVS	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.3056
p.R187Q	ACH-000999	Colon/Colorectal Cancer	CCLE	NRPLLDFVS	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.3056
p.R187Q	SNU-1040	large intestine	COSMIC	NRPLLDFVS	DEG_APCC_DBOX_1	188:196	Mutation rewiring degron network	0.3056
p.V166L	SIDM00220	Ovarian Carcinoma	GDSC	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation altering degron motif	0.6765
p.V166L	ACH-000962	Ovarian Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation altering degron motif	0.6765
p.V166L	ACH-001145	Ovarian Cancer	CCLE	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation altering degron motif	0.6765
p.V166L	OC-314	ovary	COSMIC	VPTTT	DEG_SPOP_SBC_1	166:170	Mutation altering degron motif	0.6765
p.G45A	ACH-001510	Head and Neck Cancer	CCLE	DSGEGS	DEG_SCF_TRCP1_1	52:57	Mutation rewiring degron network	0.1389
p.V195M	ACH-002348	Non-Cancerous	CCLE	NRPLLDFVS	DEG_APCC_DBOX_1	188:196	Mutation altering degron motif	0.6097
p.G64V	RKO	large intestine	COSMIC	DSGEGS	DEG_SCF_TRCP1_1	52:57	Mutation rewiring degron network	0.1389
p.G67A	HOP-62	lung	COSMIC	DSGEGS	DEG_SCF_TRCP1_1	52:57	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PHF14

UniProt ID: O94880

Entrez ID: 9678

Protein name: PHD finger protein 14

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PHF14 in