DegronMD

Uniprot ID: O94880

Source protein: PHD finger protein 14

Source gene: PHF14

Class: DEG_SCF_TRCP1_1

Location: 52:57

E3 ligase: BTRC

DEGRON score: 0.8839

ASA_SCORE: 80.5833

COIL: 0.8862

CONS_SCORE: 0.3159

DSS_SCORE: 0.7357

HELIX: 0.076

FCONS_SCORE: 0.9458

RIG_SCORE: 0.5261

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S53I	TCGA-85-A4JC	LUSC	TCGA	DSGEGS	DEG_SCF_TRCP1_1	0.8453
p.S53I	DO45429	LUSC	ICGC	DSGEGS	DEG_SCF_TRCP1_1	0.8453
p.E55D	TCGA-BR-4257	STAD	TCGA	DSGEGS	DEG_SCF_TRCP1_1	0.5647
p.E55D	DO38683	STAD	ICGC	DSGEGS	DEG_SCF_TRCP1_1	0.5647
p.G43C	TCGA-ER-A195	SKCM	TCGA	DSGEGS	DEG_SCF_TRCP1_1	0.0833
p.G43C	DO47712	SKCM	ICGC	DSGEGS	DEG_SCF_TRCP1_1	0.0833
p.E55K	DO1073	BRCA	ICGC	DSGEGS	DEG_SCF_TRCP1_1	0.591
p.G58C	DO229019	LICA	ICGC	DSGEGS	DEG_SCF_TRCP1_1	0.3056
p.H62R	DO48532	LIHC	ICGC	DSGEGS	DEG_SCF_TRCP1_1	0.1944
p.A49S	DO27899	ORCA	ICGC	DSGEGS	DEG_SCF_TRCP1_1	0.25
p.G58D	DO232761	PBCA	ICGC	DSGEGS	DEG_SCF_TRCP1_1	0.3056
p.A49P	SIDM00845	Burkitt's Lymphoma	GDSC	DSGEGS	DEG_SCF_TRCP1_1	0.25
p.A49P	SIDM00461	Acute Myeloid Leukemia	GDSC	DSGEGS	DEG_SCF_TRCP1_1	0.25
p.A49P	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DSGEGS	DEG_SCF_TRCP1_1	0.25
p.A49P	SIDM01519	Head and Neck Carcinoma	GDSC	DSGEGS	DEG_SCF_TRCP1_1	0.25
p.A49P	ACH-000786	Lymphoma	CCLE	DSGEGS	DEG_SCF_TRCP1_1	0.25
p.A49P	ACH-000992	Head and Neck Cancer	CCLE	DSGEGS	DEG_SCF_TRCP1_1	0.25
p.A49P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	DSGEGS	DEG_SCF_TRCP1_1	0.25
p.G45A	ACH-001510	Head and Neck Cancer	CCLE	DSGEGS	DEG_SCF_TRCP1_1	0.1389
p.G64V	RKO	large_intestine	COSMIC	DSGEGS	DEG_SCF_TRCP1_1	0.1389
p.G67A	HOP-62	lung	COSMIC	DSGEGS	DEG_SCF_TRCP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94880	PHD finger protein 14	DEG_SCF_TRCP1_1	52:57	DSGEGS	BTRC	0.8839	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons