DegronMD

Uniprot ID: O94880

Source protein: PHD finger protein 14

Source gene: PHF14

Class: DEG_APCC_DBOX_1

Location: 188:196

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9881

ASA_SCORE: 82.4111

COIL: 0.765

CONS_SCORE: 0.3447

DSS_SCORE: 0.3809

HELIX: 0.1142

FCONS_SCORE: 1.0547

RIG_SCORE: 0.8067

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P180L	TCGA-29-1691	OV	TCGA	NRPLLDFVS	DEG_APCC_DBOX_1	0.1111
p.P180L	DO32133	OV	ICGC	NRPLLDFVS	DEG_APCC_DBOX_1	0.1111
p.M203I	TCGA-49-AARN	LUAD	TCGA	NRPLLDFVS	DEG_APCC_DBOX_1	0.1389
p.M203I	TCGA-A5-A1OF	UCEC	TCGA	NRPLLDFVS	DEG_APCC_DBOX_1	0.1389
p.M203I	DO218923	LUAD	ICGC	NRPLLDFVS	DEG_APCC_DBOX_1	0.1389
p.M203I	DO42568	UCEC	ICGC	NRPLLDFVS	DEG_APCC_DBOX_1	0.1389
p.R189Q	TCGA-AJ-A3EK	UCEC	TCGA	NRPLLDFVS	DEG_APCC_DBOX_1	0.7329
p.R189Q	DO41584	UCEC	ICGC	NRPLLDFVS	DEG_APCC_DBOX_1	0.7329
p.R189Q	SIDM00531	Pancreatic Carcinoma	GDSC	NRPLLDFVS	DEG_APCC_DBOX_1	0.7329
p.R189Q	HuP-T4	pancreas	COSMIC	NRPLLDFVS	DEG_APCC_DBOX_1	0.7329
p.E179K	TCGA-EO-A3AV	UCEC	TCGA	NRPLLDFVS	DEG_APCC_DBOX_1	0.0833
p.E179K	DO222762	COCA	ICGC	NRPLLDFVS	DEG_APCC_DBOX_1	0.0833
p.E179K	DO52412	UCEC	ICGC	NRPLLDFVS	DEG_APCC_DBOX_1	0.0833
p.D205A	TCGA-FI-A2D5	UCEC	TCGA	NRPLLDFVS	DEG_APCC_DBOX_1	0.0833
p.D205A	DO41331	UCEC	ICGC	NRPLLDFVS	DEG_APCC_DBOX_1	0.0833
p.E200D	DO44096	COAD	ICGC	NRPLLDFVS	DEG_APCC_DBOX_1	0.2222
p.G191A	DO8479	COAD	ICGC	NRPLLDFVS	DEG_APCC_DBOX_1	0.754
p.S178G	DO223053	ESCA	ICGC	NRPLLDFVS	DEG_APCC_DBOX_1	0.0556
p.C178F	DO228976	LICA	ICGC	NRPLLDFVS	DEG_APCC_DBOX_1	0.0556
p.K189R	DO231827	LINC	ICGC	NRPLLDFVS	DEG_APCC_DBOX_1	0.7237
p.E200Q	DO23798	LUAD	ICGC	NRPLLDFVS	DEG_APCC_DBOX_1	0.2222
p.C178Y	DO52424	UCEC	ICGC	NRPLLDFVS	DEG_APCC_DBOX_1	0.0556
p.R187Q	SIDM00217	Colorectal Carcinoma	GDSC	NRPLLDFVS	DEG_APCC_DBOX_1	0.3056
p.R187Q	ACH-000999	Colon/Colorectal Cancer	CCLE	NRPLLDFVS	DEG_APCC_DBOX_1	0.3056
p.R187Q	SNU-1040	large_intestine	COSMIC	NRPLLDFVS	DEG_APCC_DBOX_1	0.3056
p.V195M	ACH-002348	Non-Cancerous	CCLE	NRPLLDFVS	DEG_APCC_DBOX_1	0.6097

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94880	PHD finger protein 14	DEG_APCC_DBOX_1	188:196	NRPLLDFVS	APC,CDC20,FZR1	0.9881	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NRPLLDFVS

Degron related mutations and impact score

Drug responses associated with PHF14 mutations

All proteins holding degron of NRPLLDFVS