DegronMD - O75563(SKAP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H242L	TCGA-44-7670	LUAD	TCGA	PLTSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1389
p.H242L	TCGA-44-7670	LUAD	TCGA	RGELYDD	LIG_APCC_ABBAyCdc20_2	233:239	Mutation rewiring degron network	0.25
p.N3K	TCGA-61-2610	OV	TCGA	PSSTS	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.3056
p.N3K	DO27982	OV	ICGC	PSSTS	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.3056
p.S9T	TCGA-94-A5I4	LUSC	TCGA	PSSTS	DEG_SPOP_SBC_1	4:8	Mutation blocking phosphorylation signal	0.75
p.S9T	DO219175	LUSC	ICGC	PSSTS	DEG_SPOP_SBC_1	4:8	Mutation blocking phosphorylation signal	0.75
p.D257V	TCGA-AA-3848	COAD	TCGA	PLTSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2222
p.E228K	TCGA-AC-A23H	BRCA	TCGA	RGELYDD	LIG_APCC_ABBAyCdc20_2	233:239	Mutation rewiring degron network	0.1944
p.Y230C	TCGA-BC-A5W4	LIHC	TCGA	RGELYDD	LIG_APCC_ABBAyCdc20_2	233:239	Mutation rewiring degron network	0.25
p.P10L	TCGA-D3-A8GQ	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.2778
p.P10L	DO51246	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.2778
p.I260M	TCGA-EO-A3B0	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.1389
p.P245L	TCGA-GN-A4U4	SKCM	TCGA	PLTSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2222
p.P245L	TCGA-GN-A4U4	SKCM	TCGA	RGELYDD	LIG_APCC_ABBAyCdc20_2	233:239	Mutation rewiring degron network	0.1667
p.Y11F	DO228483	BRCA	ICGC	PSSTS	DEG_SPOP_SBC_1	4:8	Mutation blocking phosphorylation signal	0.6944
p.Y11F	SIDM00463	T-Lymphoblastic Leukemia	GDSC	PSSTS	DEG_SPOP_SBC_1	4:8	Mutation blocking phosphorylation signal	0.6944
p.Y11F	P12-ICHIKAWA	haematopoietic and lymphoid tissue	COSMIC	PSSTS	DEG_SPOP_SBC_1	4:8	Mutation blocking phosphorylation signal	0.6944
p.T3N	DO229038	LICA	ICGC	PSSTS	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.3056
p.T3N	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.3056
p.G9R	DO229050	LICA	ICGC	PSSTS	DEG_SPOP_SBC_1	4:8	Mutation blocking phosphorylation signal	0.75
p.T3S	DO231191	LUSC	ICGC	PSSTS	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.3056
p.L7I	DO222418	MELA	ICGC	PSSTS	DEG_SPOP_SBC_1	4:8	Mutation altering degron motif	0.7174
p.N3Y	DO222423	MELA	ICGC	PSSTS	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.3056
p.N3Y	DO37425	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	4:8	Mutation rewiring degron network	0.3056
p.E262D	SIDM01308	Esophageal Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.0833
p.S253T	SIDM00845	Burkitt's Lymphoma	GDSC	PLTSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.7116
p.S253T	SIDM00855	Other Sarcomas	GDSC	PLTSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.7116
p.S253T	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.7116
p.S253T	SIDM00721	Small Cell Lung Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.7116
p.S253T	SIDM01679	Small Cell Lung Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.7116
p.S253T	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	249:253	Mutation altering degron motif	0.7116
p.D231N	SIDM00686	Endometrial Carcinoma	GDSC	RGELYDD	LIG_APCC_ABBAyCdc20_2	233:239	Mutation rewiring degron network	0.2778
p.D231N	ACH-000293	Endometrial/Uterine Cancer	CCLE	RGELYDD	LIG_APCC_ABBAyCdc20_2	233:239	Mutation rewiring degron network	0.2778
p.D231N	KLE	endometrium	COSMIC	RGELYDD	LIG_APCC_ABBAyCdc20_2	233:239	Mutation rewiring degron network	0.2778
p.D257Y	SIDM00528	Breast Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2222
p.D257Y	ACH-000934	Breast Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2222
p.D257Y	MDA-MB-361	breast	COSMIC	PLTSS	DEG_SPOP_SBC_1	249:253	Mutation rewiring degron network	0.2222

Kaplan plot for SKAP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SKAP2

UniProt ID: O75563

Entrez ID: 8935

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SKAP2 in