DegronMD

Uniprot ID: O75563

Source protein: Src kinase-associated phosphoprotein 2

Source gene: SKAP2

Class: LIG_APCC_ABBAyCdc20_2

Location: 233:239

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9967

ASA_SCORE: 71.1857

COIL: 0.6751

CONS_SCORE: 0.5349

DSS_SCORE: 0.5829

HELIX: 0.2221

FCONS_SCORE: 1.1068

RIG_SCORE: 0.7306

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H242L	TCGA-44-7670	LUAD	TCGA	RGELYDD	LIG_APCC_ABBAyCdc20_2	0.25
p.E228K	TCGA-AC-A23H	BRCA	TCGA	RGELYDD	LIG_APCC_ABBAyCdc20_2	0.1944
p.Y230C	TCGA-BC-A5W4	LIHC	TCGA	RGELYDD	LIG_APCC_ABBAyCdc20_2	0.25
p.P245L	TCGA-GN-A4U4	SKCM	TCGA	RGELYDD	LIG_APCC_ABBAyCdc20_2	0.1667
p.D231N	SIDM00686	Endometrial Carcinoma	GDSC	RGELYDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.D231N	ACH-000293	Endometrial/Uterine Cancer	CCLE	RGELYDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.D231N	KLE	endometrium	COSMIC	RGELYDD	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75563	Src kinase-associated phosphoprotein 2	LIG_APCC_ABBAyCdc20_2	233:239	RGELYDD	APC,CDC20,FZR1	0.9967	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons