DegronMD

Uniprot ID: Q6ZMY3

Source protein: SPOC domain-containing protein 1

Source gene: SPOCD1

Class: DEG_SPOP_SBC_1

Location: 193:197

E3 ligase: SPOP

DEGRON score: 0.8764

ASA_SCORE: 90.32

COIL: 0.9542

CONS_SCORE: 0.4284

DSS_SCORE: 0.6967

HELIX: 0.0186

FCONS_SCORE: 1.0378

RIG_SCORE: 0.5609

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S185N	TCGA-4X-A9FC	THYM	TCGA	PLTSS	DEG_SPOP_SBC_1	0.1111
p.K207N	TCGA-AA-A010	COAD	TCGA	PLTSS	DEG_SPOP_SBC_1	0.1667
p.R192M	TCGA-B5-A3FA	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	0.3056
p.R192M	DO52402	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	0.3056
p.R204M	TCGA-BR-4370	STAD	TCGA	PLTSS	DEG_SPOP_SBC_1	0.1389
p.R204M	TCGA-BR-7707	STAD	TCGA	PLTSS	DEG_SPOP_SBC_1	0.1389
p.R204M	DO38487	STAD	ICGC	PLTSS	DEG_SPOP_SBC_1	0.1389
p.R204M	DO38499	STAD	ICGC	PLTSS	DEG_SPOP_SBC_1	0.1389
p.P202L	TCGA-E6-A1LX	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	0.1944
p.P202L	DO41020	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	0.1944
p.E188K	TCGA-EE-A2MS	SKCM	TCGA	PLTSS	DEG_SPOP_SBC_1	0.1944
p.E188K	TCGA-FR-A726	SKCM	TCGA	PLTSS	DEG_SPOP_SBC_1	0.1944
p.E188K	DO37567	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	0.1944
p.E188K	DO48665	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	0.1944
p.R206I	TCGA-FI-A2D5	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	0.0833
p.R206I	DO41331	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	0.0833
p.L185M	DO23654	LUAD	ICGC	PLTSS	DEG_SPOP_SBC_1	0.1111
p.P189L	DO231075	LUSC	ICGC	PLTSS	DEG_SPOP_SBC_1	0.2222
p.P202S	DO222753	MELA	ICGC	PLTSS	DEG_SPOP_SBC_1	0.1944
p.M188R	DO28056	OV	ICGC	PLTSS	DEG_SPOP_SBC_1	0.1944
p.K207E	DO28641	OV	ICGC	PLTSS	DEG_SPOP_SBC_1	0.1667
p.R187Q	DO51475	PACA	ICGC	PLTSS	DEG_SPOP_SBC_1	0.1667
p.R200C	DO50284	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	0.25
p.D184N	DO47573	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	0.0833
p.D184N	DO38123	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	0.0833
p.R187W	DO41644	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	0.1667
p.L184I	SIDM00232	Kidney Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	0.0833
p.L184I	ACH-002168	Kidney Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	0.0833
p.L184I	NCC021	kidney	COSMIC	PLTSS	DEG_SPOP_SBC_1	0.0833
p.P190S	SIDM00617	Hepatocellular Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	0.25
p.P190S	SIDM00315	Glioblastoma	GDSC	PLTSS	DEG_SPOP_SBC_1	0.25
p.P190S	SIDM00410	Other Blood Cancers	GDSC	PLTSS	DEG_SPOP_SBC_1	0.25
p.P190S	SIDM01061	Oral Cavity Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	0.25
p.P190S	SIDM01551	Gastric Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	0.25
p.P190S	SIDM01776	Plasma Cell Myeloma	GDSC	PLTSS	DEG_SPOP_SBC_1	0.25
p.R206T	SIDM00679	Cervical Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	0.0833
p.R206T	ACH-001525	Cervical Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	0.0833
p.R206T	HT-3	cervix	COSMIC	PLTSS	DEG_SPOP_SBC_1	0.0833
p.P195L	NCI-H1155	lung	COSMIC	PLTSS	DEG_SPOP_SBC_1	0.7582
p.P207L	NCI-H650	lung	COSMIC	PLTSS	DEG_SPOP_SBC_1	0.1667
p.M191I	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PLTSS	DEG_SPOP_SBC_1	0.2778
p.L193P	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PLTSS	DEG_SPOP_SBC_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43586	Proline-serine-threonine phosphatase-interacting protein 1	DEG_SPOP_SBC_1	294:298	PLTSS	SPOP	0.9863	More...
O60284	Suppression of tumorigenicity 18 protein	DEG_SPOP_SBC_1	629:633	PLTSS	SPOP	0.9793	More...
O75563	Src kinase-associated phosphoprotein 2	DEG_SPOP_SBC_1	249:253	PLTSS	SPOP	0.9972	More...
O95486	Protein transport protein Sec24A	DEG_SPOP_SBC_1	226:230	PLTSS	SPOP	0.9934	More...
P15941	Mucin-1	DEG_SPOP_SBC_1	1024:1028	PLTSS	SPOP	0.8767	More...
P49736	DNA replication licensing factor MCM2	DEG_SPOP_SBC_1	23:27	PLTSS	SPOP	0.9038	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1038:1042	PLTSS	SPOP	0.6344	More...
Q15475	Homeobox protein SIX1	DEG_SPOP_SBC_1	274:278	PLTSS	SPOP	0.5507	More...
Q15691	Microtubule-associated protein RP/EB family member 1	DEG_SPOP_SBC_1	152:156	PLTSS	SPOP	0.9872	More...
Q17RY0	Cytoplasmic polyadenylation element-binding protein 4	DEG_SPOP_SBC_1	157:161	PLTSS	SPOP	0.9878	More...
Q5HYW2	NHS-like protein 2	DEG_SPOP_SBC_1	774:778	PLTSS	SPOP	0.9452	More...
Q69YQ0	Cytospin-A	DEG_SPOP_SBC_1	355:359	PLTSS	SPOP	0.9297	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	254:258	PLTSS	SPOP	0.949	More...
Q7Z434	Mitochondrial antiviral-signaling protein	DEG_SPOP_SBC_1	189:193	PLTSS	SPOP	0.9989	More...
Q8NEP3	Dynein axonemal assembly factor 1	DEG_SPOP_SBC_1	671:675	PLTSS	SPOP	0.9436	More...
Q8WXI2	Connector enhancer of kinase suppressor of ras 2	DEG_SPOP_SBC_1	775:779	PLTSS	SPOP	0.8711	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1750:1754	PLTSS	SPOP	0.9632	More...
Q96RU2	Ubiquitin carboxyl-terminal hydrolase 28	DEG_SPOP_SBC_1	514:518	PLTSS	SPOP	0.9579	More...
Q96RW7	Hemicentin-1	DEG_SPOP_SBC_1	2817:2821	PLTSS	SPOP	0.5877	More...
Q99633	Pre-mRNA-splicing factor 18	DEG_SPOP_SBC_1	58:62	PLTSS	SPOP	0.9188	More...
Q9BZE9	Tether containing UBX domain for GLUT4	DEG_SPOP_SBC_1	261:265	PLTSS	SPOP	0.9718	More...
Q9C0B0	RING finger protein unkempt homolog	DEG_SPOP_SBC_1	468:472	PLTSS	SPOP	0.7927	More...
Q9NPI1	Bromodomain-containing protein 7	DEG_SPOP_SBC_1	120:124	PLTSS	SPOP	0.9763	More...
Q9UDV6	Zinc finger protein 212	DEG_SPOP_SBC_1	17:21	PLTSS	SPOP	0.99	More...
Q9UHK0	Nuclear fragile X mental retardation-interacting protein 1	DEG_SPOP_SBC_1	49:53	PLTSS	SPOP	0.9611	More...
Q6ZMY3	SPOC domain-containing protein 1	DEG_SPOP_SBC_1	193:197	PLTSS	SPOP	0.8764	More...
Q8IWR0	Zinc finger CCCH domain-containing protein 7A	DEG_SPOP_SBC_1	347:351	PLTSS	SPOP	0.9188	More...
O94880	PHD finger protein 14	DEG_SPOP_SBC_1	568:572	PLTSS	SPOP	0.9962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLTSS

Degron related mutations and impact score

Drug responses associated with SPOCD1 mutations

All proteins holding degron of PLTSS