DegronMD - Q8IWR0(ZC3H7A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S357C	TCGA-77-8139	LUSC	TCGA	PLTSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.1667
p.S357C	DO26524	LUSC	ICGC	PLTSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.1667
p.P222S	TCGA-A2-A0CX	BRCA	TCGA	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation rewiring degron network	0.1111
p.P222S	DO2755	BRCA	ICGC	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation rewiring degron network	0.1111
p.D203Y	TCGA-AP-A1E0	UCEC	TCGA	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation rewiring degron network	0.1944
p.D203Y	DO43154	UCEC	ICGC	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation rewiring degron network	0.1944
p.D203Y	SIDM01611	Endometrial Carcinoma	GDSC	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation rewiring degron network	0.1944
p.D203Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation rewiring degron network	0.1944
p.R212M	TCGA-BF-A1Q0	SKCM	TCGA	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.7521
p.R212M	DO47374	SKCM	ICGC	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.7521
p.H199Y	TCGA-EE-A29B	SKCM	TCGA	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation rewiring degron network	0.0833
p.H199Y	DO47255	SKCM	ICGC	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation rewiring degron network	0.0833
p.S357Y	DO222762	COCA	ICGC	PLTSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.1667
p.S340C	DO233058	GACA	ICGC	PLTSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.1389
p.T210S	SIDM00305	Ovarian Carcinoma	GDSC	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.8227
p.T210S	SIDM00565	Oral Cavity Carcinoma	GDSC	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.8227
p.T210S	SIDM00375	Head and Neck Carcinoma	GDSC	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.8227
p.T210S	SIDM01444	Glioblastoma	GDSC	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.8227
p.T210S	SIDM01433	Kidney Carcinoma	GDSC	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.8227
p.T210S	ACH-000132	Ovarian Cancer	CCLE	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.8227
p.T210S	ACH-000237	Ovarian Cancer	CCLE	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.8227
p.T210S	ACH-000317	Kidney Cancer	CCLE	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.8227
p.T210S	ACH-000370	Brain Cancer	CCLE	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.8227
p.T210S	ACH-001626	Head and Neck Cancer	CCLE	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.8227
p.T210S	ACH-002305	Head and Neck Cancer	CCLE	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.8227
p.T210S	OSC-20	upper aerodigestive tract	COSMIC	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.8227
p.T210S	SKN-3	upper aerodigestive tract	COSMIC	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.8227
p.T210S	JHOS-2	ovary	COSMIC	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.8227
p.P339L	SIDM00282	Colorectal Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.1111
p.P339L	ACH-000998	Colon/Colorectal Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.1111
p.P339L	CW-2	large intestine	COSMIC	PLTSS	DEG_SPOP_SBC_1	347:351	Mutation rewiring degron network	0.1111

Kaplan plot for ZC3H7A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZC3H7A

UniProt ID: Q8IWR0

Entrez ID: 29066

Protein name: Zinc finger CCCH domain-containing protein 7A

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZC3H7A in