DegronMD - Q8IWR0(ZC3H7A)

FUNCTION: May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3'-ATA(A/T)-5' motif in the apical loop. {ECO:0000269|PubMed:28431233}.

GO - Biological processes (BP): posttranscriptional regulation of gene expression [GO:0010608]; production of miRNAs involved in gene silencing by miRNA [GO:0035196]

GO - Molecular function (MF): metal ion binding [GO:0046872]; miRNA binding [GO:0035198]; RNA binding [GO:0003723]

GO - Cellular component (CC): nucleus [GO:0005634]

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Degron hit	Class	E3 ligase	Source protein	Location	Detail
NKENG	DEG_APCC_KENBOX_2	APC,CDC20,FZR1	Zinc finger CCCH domain-containing protein 7A	837:841	More..
LLTPRQE	DEG_SCF_FBW7_2	FBXW7	Zinc finger CCCH domain-containing protein 7A	208:214	More..
PLTSS	DEG_SPOP_SBC_1	SPOP	Zinc finger CCCH domain-containing protein 7A	347:351	More..

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T210S	SIDM00305	Ovarian Carcinoma	GDSC	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.8227
p.T210S	SIDM00565	Oral Cavity Carcinoma	GDSC	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.8227
p.T210S	SIDM00375	Head and Neck Carcinoma	GDSC	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.8227
p.T210S	SIDM01444	Glioblastoma	GDSC	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.8227
p.T210S	SIDM01433	Kidney Carcinoma	GDSC	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.8227
p.T210S	ACH-000132	Ovarian Cancer	CCLE	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.8227
p.T210S	ACH-000237	Ovarian Cancer	CCLE	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.8227
p.T210S	ACH-000317	Kidney Cancer	CCLE	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.8227
p.T210S	ACH-000370	Brain Cancer	CCLE	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.8227
p.T210S	ACH-001626	Head and Neck Cancer	CCLE	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.8227
p.T210S	ACH-002305	Head and Neck Cancer	CCLE	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.8227
p.T210S	OSC-20	upper aerodigestive tract	COSMIC	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.8227
p.T210S	SKN-3	upper aerodigestive tract	COSMIC	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.8227
p.T210S	JHOS-2	ovary	COSMIC	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.8227
p.R212M	TCGA-BF-A1Q0	SKCM	TCGA	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.7521
p.R212M	DO47374	SKCM	ICGC	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation altering degron motif	0.7521
p.D203Y	TCGA-AP-A1E0	UCEC	TCGA	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation rewiring degron network	0.1944
p.D203Y	DO43154	UCEC	ICGC	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation rewiring degron network	0.1944
p.D203Y	SIDM01611	Endometrial Carcinoma	GDSC	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation rewiring degron network	0.1944
p.D203Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	LLTPRQE	DEG_SCF_FBW7_2	208:214	Mutation rewiring degron network	0.1944

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No resistance data available for this Degron.

Kaplan plot for ZC3H7A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZC3H7A

UniProt ID: Q8IWR0

Entrez ID: 29066

Protein name: Zinc finger CCCH domain-containing protein 7A

External links: UniprotKB HGNC RefSeq COSMIC

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No resistance data available for this Degron.

Kaplan plot for ZC3H7A in