DegronMD

Uniprot ID: Q8IWR0

Source protein: Zinc finger CCCH domain-containing protein 7A

Source gene: ZC3H7A

Class: DEG_SCF_FBW7_2

Location: 208:214

E3 ligase: FBXW7

DEGRON score: 0.9979

ASA_SCORE: 98.6571

COIL: 0.7323

CONS_SCORE: 0.4809

DSS_SCORE: 0.4352

HELIX: 0.2374

FCONS_SCORE: 1.0785

RIG_SCORE: 0.7553

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P222S	TCGA-A2-A0CX	BRCA	TCGA	LLTPRQE	DEG_SCF_FBW7_2	0.1111
p.P222S	DO2755	BRCA	ICGC	LLTPRQE	DEG_SCF_FBW7_2	0.1111
p.D203Y	TCGA-AP-A1E0	UCEC	TCGA	LLTPRQE	DEG_SCF_FBW7_2	0.1944
p.D203Y	DO43154	UCEC	ICGC	LLTPRQE	DEG_SCF_FBW7_2	0.1944
p.D203Y	SIDM01611	Endometrial Carcinoma	GDSC	LLTPRQE	DEG_SCF_FBW7_2	0.1944
p.D203Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	LLTPRQE	DEG_SCF_FBW7_2	0.1944
p.R212M	TCGA-BF-A1Q0	SKCM	TCGA	LLTPRQE	DEG_SCF_FBW7_2	0.7521
p.R212M	DO47374	SKCM	ICGC	LLTPRQE	DEG_SCF_FBW7_2	0.7521
p.H199Y	TCGA-EE-A29B	SKCM	TCGA	LLTPRQE	DEG_SCF_FBW7_2	0.0833
p.H199Y	DO47255	SKCM	ICGC	LLTPRQE	DEG_SCF_FBW7_2	0.0833
p.T210S	SIDM00305	Ovarian Carcinoma	GDSC	LLTPRQE	DEG_SCF_FBW7_2	0.8227
p.T210S	SIDM00565	Oral Cavity Carcinoma	GDSC	LLTPRQE	DEG_SCF_FBW7_2	0.8227
p.T210S	SIDM00375	Head and Neck Carcinoma	GDSC	LLTPRQE	DEG_SCF_FBW7_2	0.8227
p.T210S	SIDM01444	Glioblastoma	GDSC	LLTPRQE	DEG_SCF_FBW7_2	0.8227
p.T210S	SIDM01433	Kidney Carcinoma	GDSC	LLTPRQE	DEG_SCF_FBW7_2	0.8227
p.T210S	ACH-000132	Ovarian Cancer	CCLE	LLTPRQE	DEG_SCF_FBW7_2	0.8227
p.T210S	ACH-000237	Ovarian Cancer	CCLE	LLTPRQE	DEG_SCF_FBW7_2	0.8227
p.T210S	ACH-000317	Kidney Cancer	CCLE	LLTPRQE	DEG_SCF_FBW7_2	0.8227
p.T210S	ACH-000370	Brain Cancer	CCLE	LLTPRQE	DEG_SCF_FBW7_2	0.8227
p.T210S	ACH-001626	Head and Neck Cancer	CCLE	LLTPRQE	DEG_SCF_FBW7_2	0.8227
p.T210S	ACH-002305	Head and Neck Cancer	CCLE	LLTPRQE	DEG_SCF_FBW7_2	0.8227
p.T210S	OSC-20	upper_aerodigestive_tract	COSMIC	LLTPRQE	DEG_SCF_FBW7_2	0.8227
p.T210S	SKN-3	upper_aerodigestive_tract	COSMIC	LLTPRQE	DEG_SCF_FBW7_2	0.8227
p.T210S	JHOS-2	ovary	COSMIC	LLTPRQE	DEG_SCF_FBW7_2	0.8227

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWR0	Zinc finger CCCH domain-containing protein 7A	DEG_SCF_FBW7_2	208:214	LLTPRQE	FBXW7	0.9979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LLTPRQE

Degron related mutations and impact score

Drug responses associated with ZC3H7A mutations

All proteins holding degron of LLTPRQE