DegronMD - Q6ZMY3(SPOCD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S185N	TCGA-4X-A9FC	THYM	TCGA	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1111
p.K207N	TCGA-AA-A010	COAD	TCGA	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation substituting flanking lysine	0.1667
p.R192M	TCGA-B5-A3FA	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.3056
p.R192M	DO52402	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.3056
p.R204M	TCGA-BR-4370	STAD	TCGA	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1389
p.R204M	TCGA-BR-7707	STAD	TCGA	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1389
p.R204M	DO38487	STAD	ICGC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1389
p.R204M	DO38499	STAD	ICGC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1389
p.A388V	TCGA-CK-4951	COAD	TCGA	SREPLGGLS	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.2778
p.A388V	DO10582	COAD	ICGC	SREPLGGLS	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.2778
p.P202L	TCGA-E6-A1LX	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1944
p.P202L	DO41020	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1944
p.E188K	TCGA-EE-A2MS	SKCM	TCGA	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1944
p.E188K	TCGA-FR-A726	SKCM	TCGA	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1944
p.E188K	DO37567	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1944
p.E188K	DO48665	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1944
p.S399F	TCGA-EE-A3JD	SKCM	TCGA	SREPLGGLS	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.3056
p.S399F	DO50299	SKCM	ICGC	SREPLGGLS	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.3056
p.R206I	TCGA-FI-A2D5	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.0833
p.R206I	DO41331	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.0833
p.A384T	TCGA-IB-7651	PAAD	TCGA	SREPLGGLS	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.1667
p.A384T	DO46657	PAAD	ICGC	SREPLGGLS	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.1667
p.A384T	SIDM00170	Head and Neck Carcinoma	GDSC	SREPLGGLS	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.1667
p.A384T	ACH-000682	Head and Neck Cancer	CCLE	SREPLGGLS	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.1667
p.S399C	DO225234	BRCA	ICGC	SREPLGGLS	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.3056
p.D402Y	DO225261	BRCA	ICGC	SREPLGGLS	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.2222
p.S390F	DO52496	COCA	ICGC	SREPLGGLS	DEG_APCC_DBOX_1	390:398	Mutation altering degron motif	0.6871
p.G396S	DO233693	GACA	ICGC	SREPLGGLS	DEG_APCC_DBOX_1	390:398	Mutation altering degron motif	0.5882
p.T403A	DO48743	LIRI	ICGC	SREPLGGLS	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.1944
p.L390M	DO229256	LMS	ICGC	SREPLGGLS	DEG_APCC_DBOX_1	390:398	Mutation altering degron motif	0.711
p.L185M	DO23654	LUAD	ICGC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1111
p.P189L	DO231075	LUSC	ICGC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.2222
p.P202S	DO222753	MELA	ICGC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1944
p.M188R	DO28056	OV	ICGC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1944
p.K207E	DO28641	OV	ICGC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation substituting flanking lysine	0.1667
p.G381R	DO46657	PAAD	ICGC	SREPLGGLS	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.0833
p.R187Q	DO51475	PACA	ICGC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1667
p.R200C	DO50284	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.25
p.D184N	DO47573	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.0833
p.D184N	DO38123	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.0833
p.P393H	DO229272	THCA	ICGC	SREPLGGLS	DEG_APCC_DBOX_1	390:398	Mutation altering degron motif	0.6583
p.S383N	DO219773	UCEC	ICGC	SREPLGGLS	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.1389
p.R395C	DO52399	UCEC	ICGC	SREPLGGLS	DEG_APCC_DBOX_1	390:398	Mutation altering degron motif	0.8301
p.R187W	DO41644	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1667
p.W406R	DO41139	UCEC	ICGC	SREPLGGLS	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.1111
p.L184I	SIDM00232	Kidney Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.0833
p.L184I	ACH-002168	Kidney Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.0833
p.L184I	NCC021	kidney	COSMIC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.0833
p.P190S	SIDM00617	Hepatocellular Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.25
p.P190S	SIDM00315	Glioblastoma	GDSC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.25
p.P190S	SIDM00410	Other Blood Cancers	GDSC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.25
p.P190S	SIDM01061	Oral Cavity Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.25
p.P190S	SIDM01551	Gastric Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.25
p.P190S	SIDM01776	Plasma Cell Myeloma	GDSC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.25
p.S389R	SIDM00789	Colorectal Carcinoma	GDSC	SREPLGGLS	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.3056
p.S389R	ACH-000997	Colon/Colorectal Cancer	CCLE	SREPLGGLS	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.3056
p.S389R	ACH-001061	Colon/Colorectal Cancer	CCLE	SREPLGGLS	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.3056
p.S389R	HCT-15	large intestine	COSMIC	SREPLGGLS	DEG_APCC_DBOX_1	390:398	Mutation rewiring degron network	0.3056
p.R206T	SIDM00679	Cervical Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.0833
p.R206T	ACH-001525	Cervical Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.0833
p.R206T	HT-3	cervix	COSMIC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.0833
p.P195L	NCI-H1155	lung	COSMIC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation altering degron motif	0.7582
p.P207L	NCI-H650	lung	COSMIC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation substituting flanking lysine	0.1667
p.R391H	SNU-1040	large intestine	COSMIC	SREPLGGLS	DEG_APCC_DBOX_1	390:398	Mutation altering degron motif	0.8244
p.V397L	CHP-126	autonomic ganglia	COSMIC	SREPLGGLS	DEG_APCC_DBOX_1	390:398	Mutation altering degron motif	0.6765
p.M191I	DND-41	haematopoietic and lymphoid tissue	COSMIC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.2778
p.L193P	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PLTSS	DEG_SPOP_SBC_1	193:197	Mutation altering degron motif	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPOCD1

UniProt ID: Q6ZMY3

Entrez ID: 90853

Protein name: SPOC domain-containing protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPOCD1 in