DegronMD

Uniprot ID: Q6ZMY3

Source protein: SPOC domain-containing protein 1

Source gene: SPOCD1

Class: DEG_APCC_DBOX_1

Location: 390:398

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.965

ASA_SCORE: 80.2222

COIL: 0.8514

CONS_SCORE: 0.4078

DSS_SCORE: 0.5611

HELIX: 0.0944

FCONS_SCORE: 1.0012

RIG_SCORE: 0.6127

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A388V	TCGA-CK-4951	COAD	TCGA	SREPLGGLS	DEG_APCC_DBOX_1	0.2778
p.A388V	DO10582	COAD	ICGC	SREPLGGLS	DEG_APCC_DBOX_1	0.2778
p.S399F	TCGA-EE-A3JD	SKCM	TCGA	SREPLGGLS	DEG_APCC_DBOX_1	0.3056
p.S399F	DO50299	SKCM	ICGC	SREPLGGLS	DEG_APCC_DBOX_1	0.3056
p.A384T	TCGA-IB-7651	PAAD	TCGA	SREPLGGLS	DEG_APCC_DBOX_1	0.1667
p.A384T	DO46657	PAAD	ICGC	SREPLGGLS	DEG_APCC_DBOX_1	0.1667
p.A384T	SIDM00170	Head and Neck Carcinoma	GDSC	SREPLGGLS	DEG_APCC_DBOX_1	0.1667
p.A384T	ACH-000682	Head and Neck Cancer	CCLE	SREPLGGLS	DEG_APCC_DBOX_1	0.1667
p.S399C	DO225234	BRCA	ICGC	SREPLGGLS	DEG_APCC_DBOX_1	0.3056
p.D402Y	DO225261	BRCA	ICGC	SREPLGGLS	DEG_APCC_DBOX_1	0.2222
p.S390F	DO52496	COCA	ICGC	SREPLGGLS	DEG_APCC_DBOX_1	0.6871
p.G396S	DO233693	GACA	ICGC	SREPLGGLS	DEG_APCC_DBOX_1	0.5882
p.T403A	DO48743	LIRI	ICGC	SREPLGGLS	DEG_APCC_DBOX_1	0.1944
p.L390M	DO229256	LMS	ICGC	SREPLGGLS	DEG_APCC_DBOX_1	0.711
p.G381R	DO46657	PAAD	ICGC	SREPLGGLS	DEG_APCC_DBOX_1	0.0833
p.P393H	DO229272	THCA	ICGC	SREPLGGLS	DEG_APCC_DBOX_1	0.6583
p.S383N	DO219773	UCEC	ICGC	SREPLGGLS	DEG_APCC_DBOX_1	0.1389
p.R395C	DO52399	UCEC	ICGC	SREPLGGLS	DEG_APCC_DBOX_1	0.8301
p.W406R	DO41139	UCEC	ICGC	SREPLGGLS	DEG_APCC_DBOX_1	0.1111
p.S389R	SIDM00789	Colorectal Carcinoma	GDSC	SREPLGGLS	DEG_APCC_DBOX_1	0.3056
p.S389R	ACH-000997	Colon/Colorectal Cancer	CCLE	SREPLGGLS	DEG_APCC_DBOX_1	0.3056
p.S389R	ACH-001061	Colon/Colorectal Cancer	CCLE	SREPLGGLS	DEG_APCC_DBOX_1	0.3056
p.S389R	HCT-15	large_intestine	COSMIC	SREPLGGLS	DEG_APCC_DBOX_1	0.3056
p.R391H	SNU-1040	large_intestine	COSMIC	SREPLGGLS	DEG_APCC_DBOX_1	0.8244
p.V397L	CHP-126	autonomic_ganglia	COSMIC	SREPLGGLS	DEG_APCC_DBOX_1	0.6765

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZMY3	SPOC domain-containing protein 1	DEG_APCC_DBOX_1	390:398	SREPLGGLS	APC,CDC20,FZR1	0.965	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SREPLGGLS

Degron related mutations and impact score

Drug responses associated with SPOCD1 mutations

All proteins holding degron of SREPLGGLS