DegronMD - Q99633(PRPF18)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L68R	TCGA-AA-A010	COAD	TCGA	PLTSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.1667
p.S62L	TCGA-AP-A0LI	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	58:62	Mutation altering degron motif	0.7667
p.S62L	DO234232	ESAD	ICGC	PLTSS	DEG_SPOP_SBC_1	58:62	Mutation altering degron motif	0.7667
p.S62L	DO43658	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	58:62	Mutation altering degron motif	0.7667
p.L59S	TCGA-B5-A1MX	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	58:62	Mutation altering degron motif	0.6556
p.L59S	DO41999	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	58:62	Mutation altering degron motif	0.6556
p.L68F	TCGA-EE-A3JE	SKCM	TCGA	PLTSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.1667
p.L68F	DO48766	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.1667
p.E72K	TCGA-HU-A4G8	STAD	TCGA	PLTSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0556
p.E72K	DO47819	STAD	ICGC	PLTSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0556
p.D55Y	DO229025	LICA	ICGC	PLTSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.25
p.D55Y	DO229268	THCA	ICGC	PLTSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.25
p.E53G	SIDM00657	Acute Myeloid Leukemia	GDSC	PLTSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.1944
p.E53G	SIDM00230	Small Cell Lung Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.1944
p.E53G	SIDM00968	Ovarian Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.1944
p.E53G	SIDM01650	Non-Cancerous	GDSC	PLTSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.1944
p.E53G	SIDM00490	Glioma	GDSC	PLTSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.1944
p.E53G	SIDM01215	Ovarian Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.1944

Kaplan plot for PRPF18 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRPF18

UniProt ID: Q99633

Entrez ID: 8559

Protein name: Pre-mRNA-splicing factor 18 (PRP18 homolog) (hPRP18)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PRPF18 in