DegronMD - Q9UHK0(NUFIP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G58A	TCGA-22-4596	LUSC	TCGA	PLTSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.1944
p.G58A	DO27739	LUSC	ICGC	PLTSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.1944
p.G369D	TCGA-63-A5MM	LUSC	TCGA	PEETPIKT	DEG_SCF_FBW7_1	378:385	Mutation rewiring degron network	0.0833
p.G369D	TCGA-63-A5MM	LUSC	TCGA	EPEETPIK	DEG_SCF_SKP2-CKS1_1	377:384	Mutation rewiring degron network	0.1111
p.G369D	DO219153	LUSC	ICGC	PEETPIKT	DEG_SCF_FBW7_1	378:385	Mutation rewiring degron network	0.0833
p.G369D	DO219153	LUSC	ICGC	EPEETPIK	DEG_SCF_SKP2-CKS1_1	377:384	Mutation rewiring degron network	0.1111
p.V389I	TCGA-75-6214	LUAD	TCGA	PEETPIKT	DEG_SCF_FBW7_1	378:385	Mutation rewiring degron network	0.2222
p.V389I	TCGA-75-6214	LUAD	TCGA	EPEETPIK	DEG_SCF_SKP2-CKS1_1	377:384	Mutation rewiring degron network	0.1944
p.V389I	DO24830	LUAD	ICGC	PEETPIKT	DEG_SCF_FBW7_1	378:385	Mutation rewiring degron network	0.2222
p.V389I	DO24830	LUAD	ICGC	EPEETPIK	DEG_SCF_SKP2-CKS1_1	377:384	Mutation rewiring degron network	0.1944
p.S367I	TCGA-77-8128	LUSC	TCGA	EPEETPIK	DEG_SCF_SKP2-CKS1_1	377:384	Mutation rewiring degron network	0.0556
p.S367I	DO26464	LUSC	ICGC	EPEETPIK	DEG_SCF_SKP2-CKS1_1	377:384	Mutation rewiring degron network	0.0556
p.V269I	TCGA-AB-2828	LAML	TCGA	VLTTT	DEG_SPOP_SBC_1	269:273	Mutation altering degron motif	0.7076
p.V269I	DO21571	LAML	ICGC	VLTTT	DEG_SPOP_SBC_1	269:273	Mutation altering degron motif	0.7076
p.M278I	TCGA-AG-A00Y	READ	TCGA	VLTTT	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1944
p.M278I	DO36542	READ	ICGC	VLTTT	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1944
p.W40C	TCGA-EE-A181	SKCM	TCGA	PLTSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.0833
p.W40C	DO37444	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.0833
p.L261R	TCGA-EY-A1G8	UCEC	TCGA	VLTTT	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1111
p.L261R	DO43578	UCEC	ICGC	VLTTT	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1111
p.G280V	TCGA-F1-6874	STAD	TCGA	VLTTT	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1389
p.G280V	DO38201	STAD	ICGC	VLTTT	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1389
p.K277N	TCGA-F7-A50J	HNSC	TCGA	VLTTT	DEG_SPOP_SBC_1	269:273	Mutation substituting flanking lysine	0.3333
p.K277N	DO44431	HNSC	ICGC	VLTTT	DEG_SPOP_SBC_1	269:273	Mutation substituting flanking lysine	0.3333
p.E379Q	TCGA-ZF-A9R0	BLCA	TCGA	PEETPIKT	DEG_SCF_FBW7_1	378:385	Mutation altering degron motif	0.5633
p.E379Q	TCGA-ZF-A9R0	BLCA	TCGA	EPEETPIK	DEG_SCF_SKP2-CKS1_1	377:384	Mutation altering degron motif	0.6744
p.E379Q	DO219055	BLCA	ICGC	PEETPIKT	DEG_SCF_FBW7_1	378:385	Mutation altering degron motif	0.5633
p.E379Q	DO219055	BLCA	ICGC	EPEETPIK	DEG_SCF_SKP2-CKS1_1	377:384	Mutation altering degron motif	0.6744
p.E386G	DO222487	ESCA	ICGC	PEETPIKT	DEG_SCF_FBW7_1	378:385	Mutation rewiring degron network	0.3056
p.E386G	DO222487	ESCA	ICGC	EPEETPIK	DEG_SCF_SKP2-CKS1_1	377:384	Mutation rewiring degron network	0.2778
p.M42I	DO233272	GACA	ICGC	PLTSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.1389
p.P382H	DO233766	GACA	ICGC	PEETPIKT	DEG_SCF_FBW7_1	378:385	Mutation altering degron motif	0.7694
p.P382H	DO233766	GACA	ICGC	EPEETPIK	DEG_SCF_SKP2-CKS1_1	377:384	Mutation altering degron motif	0.7694
p.P378T	DO228952	LICA	ICGC	PEETPIKT	DEG_SCF_FBW7_1	378:385	Mutation altering degron motif	0.7031
p.P378T	DO228952	LICA	ICGC	EPEETPIK	DEG_SCF_SKP2-CKS1_1	377:384	Mutation altering degron motif	0.5919
p.P55T	DO229027	LICA	ICGC	PLTSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.2778
p.E375V	DO23186	LINC	ICGC	PEETPIKT	DEG_SCF_FBW7_1	378:385	Mutation rewiring degron network	0.25
p.E375V	DO23186	LINC	ICGC	EPEETPIK	DEG_SCF_SKP2-CKS1_1	377:384	Mutation rewiring degron network	0.2778
p.S62F	DO23308	LINC	ICGC	PLTSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.0833
p.E262Q	SIDM00240	Cervical Carcinoma	GDSC	VLTTT	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1389
p.E262Q	ACH-002180	Cervical Cancer	CCLE	VLTTT	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1389
p.E262Q	OMC-1	cervix	COSMIC	VLTTT	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1389

Kaplan plot for NUFIP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NUFIP1

UniProt ID: Q9UHK0

Entrez ID: 26747

Protein name: Nuclear fragile X mental retardation-interacting protein 1 (Nuclear FMRP-interacting protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NUFIP1 in