DegronMD

Uniprot ID: Q9UHK0

Source protein: Nuclear fragile X mental retardation-interacting protein 1

Source gene: NUFIP1

Class: DEG_SCF_FBW7_1

Location: 378:385

E3 ligase: FBXW7

DEGRON score: 0.7318

ASA_SCORE: 106.85

COIL: 0.8944

CONS_SCORE: 0.381

DSS_SCORE: 0.6739

HELIX: 0.0776

FCONS_SCORE: 0.8985

RIG_SCORE: 0.6776

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G369D	TCGA-63-A5MM	LUSC	TCGA	PEETPIKT	DEG_SCF_FBW7_1	0.0833
p.G369D	DO219153	LUSC	ICGC	PEETPIKT	DEG_SCF_FBW7_1	0.0833
p.V389I	TCGA-75-6214	LUAD	TCGA	PEETPIKT	DEG_SCF_FBW7_1	0.2222
p.V389I	DO24830	LUAD	ICGC	PEETPIKT	DEG_SCF_FBW7_1	0.2222
p.E379Q	TCGA-ZF-A9R0	BLCA	TCGA	PEETPIKT	DEG_SCF_FBW7_1	0.5633
p.E379Q	DO219055	BLCA	ICGC	PEETPIKT	DEG_SCF_FBW7_1	0.5633
p.E386G	DO222487	ESCA	ICGC	PEETPIKT	DEG_SCF_FBW7_1	0.3056
p.P382H	DO233766	GACA	ICGC	PEETPIKT	DEG_SCF_FBW7_1	0.7694
p.P378T	DO228952	LICA	ICGC	PEETPIKT	DEG_SCF_FBW7_1	0.7031
p.E375V	DO23186	LINC	ICGC	PEETPIKT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHK0	Nuclear fragile X mental retardation-interacting protein 1	DEG_SCF_FBW7_1	378:385	PEETPIKT	FBXW7	0.7318	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons