DegronMD

Uniprot ID: Q9UHK0

Source protein: Nuclear fragile X mental retardation-interacting protein 1

Source gene: NUFIP1

Class: DEG_SCF_SKP2-CKS1_1

Location: 377:384

E3 ligase: SKP2,CSK1

DEGRON score: 0.5796

ASA_SCORE: 110.8625

COIL: 0.9084

CONS_SCORE: 0.3833

DSS_SCORE: 0.6719

HELIX: 0.0605

FCONS_SCORE: 0.9005

RIG_SCORE: 0.6581

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G369D	TCGA-63-A5MM	LUSC	TCGA	EPEETPIK	DEG_SCF_SKP2-CKS1_1	0.1111
p.G369D	DO219153	LUSC	ICGC	EPEETPIK	DEG_SCF_SKP2-CKS1_1	0.1111
p.V389I	TCGA-75-6214	LUAD	TCGA	EPEETPIK	DEG_SCF_SKP2-CKS1_1	0.1944
p.V389I	DO24830	LUAD	ICGC	EPEETPIK	DEG_SCF_SKP2-CKS1_1	0.1944
p.S367I	TCGA-77-8128	LUSC	TCGA	EPEETPIK	DEG_SCF_SKP2-CKS1_1	0.0556
p.S367I	DO26464	LUSC	ICGC	EPEETPIK	DEG_SCF_SKP2-CKS1_1	0.0556
p.E379Q	TCGA-ZF-A9R0	BLCA	TCGA	EPEETPIK	DEG_SCF_SKP2-CKS1_1	0.6744
p.E379Q	DO219055	BLCA	ICGC	EPEETPIK	DEG_SCF_SKP2-CKS1_1	0.6744
p.E386G	DO222487	ESCA	ICGC	EPEETPIK	DEG_SCF_SKP2-CKS1_1	0.2778
p.P382H	DO233766	GACA	ICGC	EPEETPIK	DEG_SCF_SKP2-CKS1_1	0.7694
p.P378T	DO228952	LICA	ICGC	EPEETPIK	DEG_SCF_SKP2-CKS1_1	0.5919
p.E375V	DO23186	LINC	ICGC	EPEETPIK	DEG_SCF_SKP2-CKS1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHK0	Nuclear fragile X mental retardation-interacting protein 1	DEG_SCF_SKP2-CKS1_1	377:384	EPEETPIK	SKP2,CSK1	0.5796	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons