DegronMD

Uniprot ID: Q9UHK0

Source protein: Nuclear fragile X mental retardation-interacting protein 1

Source gene: NUFIP1

Class: DEG_SPOP_SBC_1

Location: 269:273

E3 ligase: SPOP

DEGRON score: 0.9948

ASA_SCORE: 76.24

COIL: 0.7274

CONS_SCORE: 0.4867

DSS_SCORE: 0.5308

HELIX: 0.101

FCONS_SCORE: 1.0395

RIG_SCORE: 0.7908

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V269I	TCGA-AB-2828	LAML	TCGA	VLTTT	DEG_SPOP_SBC_1	0.7076
p.V269I	DO21571	LAML	ICGC	VLTTT	DEG_SPOP_SBC_1	0.7076
p.M278I	TCGA-AG-A00Y	READ	TCGA	VLTTT	DEG_SPOP_SBC_1	0.1944
p.M278I	DO36542	READ	ICGC	VLTTT	DEG_SPOP_SBC_1	0.1944
p.L261R	TCGA-EY-A1G8	UCEC	TCGA	VLTTT	DEG_SPOP_SBC_1	0.1111
p.L261R	DO43578	UCEC	ICGC	VLTTT	DEG_SPOP_SBC_1	0.1111
p.G280V	TCGA-F1-6874	STAD	TCGA	VLTTT	DEG_SPOP_SBC_1	0.1389
p.G280V	DO38201	STAD	ICGC	VLTTT	DEG_SPOP_SBC_1	0.1389
p.K277N	TCGA-F7-A50J	HNSC	TCGA	VLTTT	DEG_SPOP_SBC_1	0.3333
p.K277N	DO44431	HNSC	ICGC	VLTTT	DEG_SPOP_SBC_1	0.3333
p.E262Q	SIDM00240	Cervical Carcinoma	GDSC	VLTTT	DEG_SPOP_SBC_1	0.1389
p.E262Q	ACH-002180	Cervical Cancer	CCLE	VLTTT	DEG_SPOP_SBC_1	0.1389
p.E262Q	OMC-1	cervix	COSMIC	VLTTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75122	CLIP-associating protein 2	DEG_SPOP_SBC_1	467:471	VLTTT	SPOP	0.8497	More...
Q6UX71	Plexin domain-containing protein 2	DEG_SPOP_SBC_1	405:409	VLTTT	SPOP	0.9915	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1938:1942	VLTTT	SPOP	0.9657	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2161:2165	VLTTT	SPOP	0.9474	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2579:2583	VLTTT	SPOP	0.8775	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2608:2612	VLTTT	SPOP	0.9605	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2661:2665	VLTTT	SPOP	0.9314	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2718:2722	VLTTT	SPOP	0.8929	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3279:3283	VLTTT	SPOP	0.9759	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3361:3365	VLTTT	SPOP	0.818	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3418:3422	VLTTT	SPOP	0.9812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3836:3840	VLTTT	SPOP	0.5559	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3918:3922	VLTTT	SPOP	0.835	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3975:3979	VLTTT	SPOP	0.8129	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4651:4655	VLTTT	SPOP	0.812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4792:4796	VLTTT	SPOP	0.9603	More...
Q9UHK0	Nuclear fragile X mental retardation-interacting protein 1	DEG_SPOP_SBC_1	269:273	VLTTT	SPOP	0.9948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons