DegronMD - Q6UX71(PLXDC2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L406P	TCGA-96-A4JK	LUSC	TCGA	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.6471
p.A398V	TCGA-A5-A0G1	UCEC	TCGA	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.1389
p.A398V	TCGA-AP-A051	UCEC	TCGA	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.1389
p.R404S	TCGA-AA-3856	COAD	TCGA	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.3056
p.R404S	TCGA-D3-A1Q3	SKCM	TCGA	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.3056
p.T414N	TCGA-CA-6717	COAD	TCGA	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation blocking phosphorylation signal	0.6389
p.T408A	TCGA-FI-A2F4	UCEC	TCGA	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.7139
p.R410I	TCGA-HG-A2PA	CESC	TCGA	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.3056
p.P418S	TCGA-IH-A3EA	SKCM	TCGA	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.0833
p.I409V	DO229010	COCA	ICGC	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.7076
p.I409V	DO229013	COCA	ICGC	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.7076
p.I409V	DO229003	COCA	ICGC	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.7076
p.I409V	DO229005	COCA	ICGC	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.7076
p.I409V	DO229346	LAML	ICGC	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.7076
p.I409V	DO225404	LAML	ICGC	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.7076
p.I409V	DO228947	LICA	ICGC	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.7076
p.A405T	DO233766	GACA	ICGC	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.7139
p.A405T	DO23156	LINC	ICGC	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.7139
p.A405T	DO45087	LINC	ICGC	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.7139
p.A405T	PANC-02-03	pancreas	COSMIC	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.7139
p.A419S	DO229034	LICA	ICGC	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation blocking phosphorylation signal	0.5
p.A405S	DO24739	LUAD	ICGC	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.7588
p.E397D	DO51690	PAAD	ICGC	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.1111
p.L403I	DO43186	UCEC	ICGC	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.2778
p.L414M	DO41752	UCEC	ICGC	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation blocking phosphorylation signal	0.6389
p.T409I	SIDM01163	Non-Small Cell Lung Carcinoma	GDSC	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.7078
p.T409I	ACH-000677	Lung Cancer	CCLE	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.7078
p.T409I	SW1573	lung	COSMIC	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation altering degron motif	0.7078
p.R411K	SIDM00545	Melanoma	GDSC	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.2778
p.R411K	ACH-000987	Skin Cancer	CCLE	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.2778
p.R411K	Mewo	skin	COSMIC	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.2778
p.P418L	SIDM01175	Other Sarcomas	GDSC	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.0833
p.P418L	ACH-002309	Sarcoma	CCLE	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.0833
p.P418L	SW684	soft tissue	COSMIC	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.0833
p.R404G	SIDM00164	Biliary Tract Carcinoma	GDSC	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.3056
p.R404G	ACH-000209	Bile Duct Cancer	CCLE	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.3056
p.V413A	SIDM01424	B-Lymphoblastic Leukemia	GDSC	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.2222
p.V413A	ACH-000782	Leukemia	CCLE	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.2222
p.V413A	ACH-001735	Leukemia	CCLE	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.2222
p.T402A	A375	skin	COSMIC	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.25
p.I413F	PE/CA-PJ15	upper aerodigestive tract	COSMIC	VLTTT	DEG_SPOP_SBC_1	405:409	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLXDC2

UniProt ID: Q6UX71

Entrez ID: 84898

Protein name: Plexin domain-containing protein 2 (Tumor endothelial marker 7-related protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLXDC2 in