DegronMD

Uniprot ID: Q6UX71

Source protein: Plexin domain-containing protein 2

Source gene: PLXDC2

Class: DEG_SPOP_SBC_1

Location: 405:409

E3 ligase: SPOP

DEGRON score: 0.9915

ASA_SCORE: 86.64

COIL: 0.834

CONS_SCORE: 0.3295

DSS_SCORE: 0.4658

HELIX: 0.0534

FCONS_SCORE: 1.1298

RIG_SCORE: 0.8783

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L406P	TCGA-96-A4JK	LUSC	TCGA	VLTTT	DEG_SPOP_SBC_1	0.6471
p.A398V	TCGA-A5-A0G1	UCEC	TCGA	VLTTT	DEG_SPOP_SBC_1	0.1389
p.A398V	TCGA-AP-A051	UCEC	TCGA	VLTTT	DEG_SPOP_SBC_1	0.1389
p.R404S	TCGA-AA-3856	COAD	TCGA	VLTTT	DEG_SPOP_SBC_1	0.3056
p.R404S	TCGA-D3-A1Q3	SKCM	TCGA	VLTTT	DEG_SPOP_SBC_1	0.3056
p.T414N	TCGA-CA-6717	COAD	TCGA	VLTTT	DEG_SPOP_SBC_1	0.6389
p.T408A	TCGA-FI-A2F4	UCEC	TCGA	VLTTT	DEG_SPOP_SBC_1	0.7139
p.R410I	TCGA-HG-A2PA	CESC	TCGA	VLTTT	DEG_SPOP_SBC_1	0.3056
p.P418S	TCGA-IH-A3EA	SKCM	TCGA	VLTTT	DEG_SPOP_SBC_1	0.0833
p.I409V	DO229010	COCA	ICGC	VLTTT	DEG_SPOP_SBC_1	0.7076
p.I409V	DO229013	COCA	ICGC	VLTTT	DEG_SPOP_SBC_1	0.7076
p.I409V	DO229003	COCA	ICGC	VLTTT	DEG_SPOP_SBC_1	0.7076
p.I409V	DO229005	COCA	ICGC	VLTTT	DEG_SPOP_SBC_1	0.7076
p.I409V	DO229346	LAML	ICGC	VLTTT	DEG_SPOP_SBC_1	0.7076
p.I409V	DO225404	LAML	ICGC	VLTTT	DEG_SPOP_SBC_1	0.7076
p.I409V	DO228947	LICA	ICGC	VLTTT	DEG_SPOP_SBC_1	0.7076
p.A405T	DO233766	GACA	ICGC	VLTTT	DEG_SPOP_SBC_1	0.7139
p.A405T	DO23156	LINC	ICGC	VLTTT	DEG_SPOP_SBC_1	0.7139
p.A405T	DO45087	LINC	ICGC	VLTTT	DEG_SPOP_SBC_1	0.7139
p.A405T	PANC-02-03	pancreas	COSMIC	VLTTT	DEG_SPOP_SBC_1	0.7139
p.A419S	DO229034	LICA	ICGC	VLTTT	DEG_SPOP_SBC_1	0.5
p.A405S	DO24739	LUAD	ICGC	VLTTT	DEG_SPOP_SBC_1	0.7588
p.E397D	DO51690	PAAD	ICGC	VLTTT	DEG_SPOP_SBC_1	0.1111
p.L403I	DO43186	UCEC	ICGC	VLTTT	DEG_SPOP_SBC_1	0.2778
p.L414M	DO41752	UCEC	ICGC	VLTTT	DEG_SPOP_SBC_1	0.6389
p.T409I	SIDM01163	Non-Small Cell Lung Carcinoma	GDSC	VLTTT	DEG_SPOP_SBC_1	0.7078
p.T409I	ACH-000677	Lung Cancer	CCLE	VLTTT	DEG_SPOP_SBC_1	0.7078
p.T409I	SW1573	lung	COSMIC	VLTTT	DEG_SPOP_SBC_1	0.7078
p.R411K	SIDM00545	Melanoma	GDSC	VLTTT	DEG_SPOP_SBC_1	0.2778
p.R411K	ACH-000987	Skin Cancer	CCLE	VLTTT	DEG_SPOP_SBC_1	0.2778
p.R411K	Mewo	skin	COSMIC	VLTTT	DEG_SPOP_SBC_1	0.2778
p.P418L	SIDM01175	Other Sarcomas	GDSC	VLTTT	DEG_SPOP_SBC_1	0.0833
p.P418L	ACH-002309	Sarcoma	CCLE	VLTTT	DEG_SPOP_SBC_1	0.0833
p.P418L	SW684	soft_tissue	COSMIC	VLTTT	DEG_SPOP_SBC_1	0.0833
p.R404G	SIDM00164	Biliary Tract Carcinoma	GDSC	VLTTT	DEG_SPOP_SBC_1	0.3056
p.R404G	ACH-000209	Bile Duct Cancer	CCLE	VLTTT	DEG_SPOP_SBC_1	0.3056
p.V413A	SIDM01424	B-Lymphoblastic Leukemia	GDSC	VLTTT	DEG_SPOP_SBC_1	0.2222
p.V413A	ACH-000782	Leukemia	CCLE	VLTTT	DEG_SPOP_SBC_1	0.2222
p.V413A	ACH-001735	Leukemia	CCLE	VLTTT	DEG_SPOP_SBC_1	0.2222
p.T402A	A375	skin	COSMIC	VLTTT	DEG_SPOP_SBC_1	0.25
p.I413F	PE/CA-PJ15	upper_aerodigestive_tract	COSMIC	VLTTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75122	CLIP-associating protein 2	DEG_SPOP_SBC_1	467:471	VLTTT	SPOP	0.8497	More...
Q6UX71	Plexin domain-containing protein 2	DEG_SPOP_SBC_1	405:409	VLTTT	SPOP	0.9915	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1938:1942	VLTTT	SPOP	0.9657	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2161:2165	VLTTT	SPOP	0.9474	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2579:2583	VLTTT	SPOP	0.8775	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2608:2612	VLTTT	SPOP	0.9605	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2661:2665	VLTTT	SPOP	0.9314	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2718:2722	VLTTT	SPOP	0.8929	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3279:3283	VLTTT	SPOP	0.9759	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3361:3365	VLTTT	SPOP	0.818	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3418:3422	VLTTT	SPOP	0.9812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3836:3840	VLTTT	SPOP	0.5559	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3918:3922	VLTTT	SPOP	0.835	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3975:3979	VLTTT	SPOP	0.8129	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4651:4655	VLTTT	SPOP	0.812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4792:4796	VLTTT	SPOP	0.9603	More...
Q9UHK0	Nuclear fragile X mental retardation-interacting protein 1	DEG_SPOP_SBC_1	269:273	VLTTT	SPOP	0.9948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VLTTT

Degron related mutations and impact score

Drug responses associated with PLXDC2 mutations

All proteins holding degron of VLTTT