DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 3975:3979

E3 ligase: SPOP

DEGRON score: 0.8129

ASA_SCORE: 99.46

COIL: 0.8952

CONS_SCORE: 0.3318

DSS_SCORE: 0.6493

HELIX: 0.0162

FCONS_SCORE: 1.0904

RIG_SCORE: 0.7481

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I3975F	DO229227	THCA	ICGC	VLTTT	DEG_SPOP_SBC_1	0.7415
p.V3978L	DO228948	LICA	ICGC	VLTTT	DEG_SPOP_SBC_1	0.6765
p.A3983T	DO42673	UCEC	ICGC	VLTTT	DEG_SPOP_SBC_1	0.2222

Showing 1 to 3 of 3 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75122	CLIP-associating protein 2	DEG_SPOP_SBC_1	467:471	VLTTT	SPOP	0.8497	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1938:1942	VLTTT	SPOP	0.9657	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2161:2165	VLTTT	SPOP	0.9474	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2579:2583	VLTTT	SPOP	0.8775	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2608:2612	VLTTT	SPOP	0.9605	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2661:2665	VLTTT	SPOP	0.9314	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2718:2722	VLTTT	SPOP	0.8929	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3279:3283	VLTTT	SPOP	0.9759	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3361:3365	VLTTT	SPOP	0.818	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3418:3422	VLTTT	SPOP	0.9812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3836:3840	VLTTT	SPOP	0.5559	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3918:3922	VLTTT	SPOP	0.835	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3975:3979	VLTTT	SPOP	0.8129	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4651:4655	VLTTT	SPOP	0.812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4792:4796	VLTTT	SPOP	0.9603	More...
Q9UHK0	Nuclear fragile X mental retardation-interacting protein 1	DEG_SPOP_SBC_1	269:273	VLTTT	SPOP	0.9948	More...
Q6UX71	Plexin domain-containing protein 2	DEG_SPOP_SBC_1	405:409	VLTTT	SPOP	0.9915	More...

Showing 1 to 17 of 17 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons