DegronMD - O75122(CLASP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S481L	TCGA-2W-A8YY	CESC	TCGA	VLTTT	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.0556
p.V462L	TCGA-69-A59K	LUAD	TCGA	VLTTT	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.1944
p.E1037D	TCGA-A5-A0G9	UCEC	TCGA	KEAMFDD	LIG_APCC_ABBAyCdc20_2	1037:1043	Mutation altering degron motif	0.6758
p.R1044L	TCGA-AP-A1E1	UCEC	TCGA	KEAMFDD	LIG_APCC_ABBAyCdc20_2	1037:1043	Mutation rewiring degron network	0.3056
p.L473S	TCGA-AX-A1CE	UCEC	TCGA	VLTTT	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.2778
p.S466L	TCGA-FW-A3R5	SKCM	TCGA	VLTTT	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.3056
p.E1051Q	TCGA-IG-A4P3	ESCA	TCGA	KEAMFDD	LIG_APCC_ABBAyCdc20_2	1037:1043	Mutation rewiring degron network	0.1111
p.E1051Q	TCGA-QK-A6V9	HNSC	TCGA	KEAMFDD	LIG_APCC_ABBAyCdc20_2	1037:1043	Mutation rewiring degron network	0.1111
p.R1039C	TCGA-QQ-A8VF	SARC	TCGA	KEAMFDD	LIG_APCC_ABBAyCdc20_2	1037:1043	Mutation altering degron motif	0.8301
p.R1039C	ACH-000952	Prostate Cancer	CCLE	KEAMFDD	LIG_APCC_ABBAyCdc20_2	1037:1043	Mutation altering degron motif	0.8301
p.N1034H	TCGA-QR-A70J	PCPG	TCGA	KEAMFDD	LIG_APCC_ABBAyCdc20_2	1037:1043	Mutation blocking phosphorylation signal	0.6944
p.H1045L	DO23740	LUAD	ICGC	KEAMFDD	LIG_APCC_ABBAyCdc20_2	1037:1043	Mutation rewiring degron network	0.2778
p.R463L	DO23564	LUAD	ICGC	VLTTT	DEG_SPOP_SBC_1	467:471	Mutation blocking phosphorylation signal	0.6667
p.D1040Y	DO37444	SKCM	ICGC	KEAMFDD	LIG_APCC_ABBAyCdc20_2	1037:1043	Mutation altering degron motif	0.7325
p.D1040Y	DO47672	SKCM	ICGC	KEAMFDD	LIG_APCC_ABBAyCdc20_2	1037:1043	Mutation altering degron motif	0.7325
p.D1035N	DO38823	STAD	ICGC	KEAMFDD	LIG_APCC_ABBAyCdc20_2	1037:1043	Mutation rewiring degron network	0.2778
p.A475T	DO47777	STAD	ICGC	VLTTT	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.2222
p.R1040C	SIDM01664	Prostate Carcinoma	GDSC	KEAMFDD	LIG_APCC_ABBAyCdc20_2	1037:1043	Mutation altering degron motif	0.8301
p.E476K	ACH-001148	Lymphoma	CCLE	VLTTT	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.1944
p.D1050Y	NCI-H1688	lung	COSMIC	KEAMFDD	LIG_APCC_ABBAyCdc20_2	1037:1043	Mutation rewiring degron network	0.1389
p.D1030Y	NCI-H1688	lung	COSMIC	KEAMFDD	LIG_APCC_ABBAyCdc20_2	1037:1043	Mutation rewiring degron network	0.1389
p.Q481H	Calu-3	lung	COSMIC	VLTTT	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.0556
p.S1039R	SCaBER	urinary tract	COSMIC	KEAMFDD	LIG_APCC_ABBAyCdc20_2	1037:1043	Mutation altering degron motif	0.7427
p.S1028R	SCaBER	urinary tract	COSMIC	KEAMFDD	LIG_APCC_ABBAyCdc20_2	1037:1043	Mutation rewiring degron network	0.0833
p.T475A	huH-1	liver	COSMIC	VLTTT	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.2222

Kaplan plot for CLASP2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CLASP2

UniProt ID: O75122

Entrez ID: 23122

Protein name: CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2) (Protein Orbit homolog 2) (hOrbit2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CLASP2 in