DegronMD

Uniprot ID: O75122

Source protein: CLIP-associating protein 2

Source gene: CLASP2

Class: DEG_SPOP_SBC_1

Location: 467:471

E3 ligase: SPOP

DEGRON score: 0.8497

ASA_SCORE: 74.78

COIL: 0.63

CONS_SCORE: 0.2349

DSS_SCORE: 0.5678

HELIX: 0.1804

FCONS_SCORE: 0.7884

RIG_SCORE: 0.7371

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S481L	TCGA-2W-A8YY	CESC	TCGA	VLTTT	DEG_SPOP_SBC_1	0.0556
p.V462L	TCGA-69-A59K	LUAD	TCGA	VLTTT	DEG_SPOP_SBC_1	0.1944
p.L473S	TCGA-AX-A1CE	UCEC	TCGA	VLTTT	DEG_SPOP_SBC_1	0.2778
p.S466L	TCGA-FW-A3R5	SKCM	TCGA	VLTTT	DEG_SPOP_SBC_1	0.3056
p.R463L	DO23564	LUAD	ICGC	VLTTT	DEG_SPOP_SBC_1	0.6667
p.A475T	DO47777	STAD	ICGC	VLTTT	DEG_SPOP_SBC_1	0.2222
p.E476K	ACH-001148	Lymphoma	CCLE	VLTTT	DEG_SPOP_SBC_1	0.1944
p.Q481H	Calu-3	lung	COSMIC	VLTTT	DEG_SPOP_SBC_1	0.0556
p.T475A	huH-1	liver	COSMIC	VLTTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75122	CLIP-associating protein 2	DEG_SPOP_SBC_1	467:471	VLTTT	SPOP	0.8497	More...
Q6UX71	Plexin domain-containing protein 2	DEG_SPOP_SBC_1	405:409	VLTTT	SPOP	0.9915	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1938:1942	VLTTT	SPOP	0.9657	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2161:2165	VLTTT	SPOP	0.9474	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2579:2583	VLTTT	SPOP	0.8775	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2608:2612	VLTTT	SPOP	0.9605	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2661:2665	VLTTT	SPOP	0.9314	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	2718:2722	VLTTT	SPOP	0.8929	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3279:3283	VLTTT	SPOP	0.9759	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3361:3365	VLTTT	SPOP	0.818	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3418:3422	VLTTT	SPOP	0.9812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3836:3840	VLTTT	SPOP	0.5559	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3918:3922	VLTTT	SPOP	0.835	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3975:3979	VLTTT	SPOP	0.8129	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4651:4655	VLTTT	SPOP	0.812	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4792:4796	VLTTT	SPOP	0.9603	More...
Q9UHK0	Nuclear fragile X mental retardation-interacting protein 1	DEG_SPOP_SBC_1	269:273	VLTTT	SPOP	0.9948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons